Does everyone have the potential to achieve their ideal body weight? Lay theories about body weight and support for price discrimination policies by Li, Kevin Shaobo, Kokkoris, Michail D., Savani, Krishna

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Structure and subunit arrangement of Mycobacterial F1FO ATP synthase and novel features of the unique mycobacterial subunit δ by Kamariah, Neelagandan, Huber, Roland G., Nartey, Wilson, Bhushan, Shashi, Bond, Peter J., Grüber, Gerhard

“…The arrangement of δ relative to the N-termini of the catalytic α3β3-headpiece and its potential as a drug target are discussed.…”
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Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…The MtRel is the only regulator of (p)ppGpp and can serve as a potential target for therapeutic interventions against drug tolerant tuberculosis and latent tuberculosis infection. …”
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Polymeric composites for powder-based additive manufacturing : materials and applications by Yuan, Shangqin, Shen, Fei, Chua, Chee Kai, Zhou, Kun

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1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity by Yang, Xuan, Wedajo, Wassihun, Yamada, Yoshiyuki, Dahlroth, Sue-Li, Neo, Jason Jun-Long, Dick, Thomas, Chui, Wai-Keung

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Real-time nanoplasmonic sensing of three-dimensional morphological changes in a supported lipid bilayer and antimicrobial testing applications by Yoon, Bo Kyeong, Park, Hyeonjin, Zhdanov, Vladimir P., Jackman, Joshua A., Cho, Nam-Joon

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Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation by Ma, Enguang, Chen, Kai, Sun, Liang, Fu, Zhinan, Guo, Jiangtao, Liu, Jichang, Zhao, Jigang, Liu, Zhiyong, Lei, Zhigang, Li, Li, Hu, Xiao, Guo, Xuhong

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The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions by Ahmed, Syed Moiz, Ragunathan, Priya, Shin, Joon, Peter, Sabrina, Kleissle, Sabrina, Neuenschwander, Martin, Schäfer, Reinhold, Kries, Jens Peter V., Grüber, Gerhard, Dröge, Peter

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Revealing the biotoxicity of phosphorene oxide nanosheets based on the villin headpiece by Zhang, Wei, Gou, Yuanyuan, Cheng, Li, Dong, Kaiwei, Sheng, Yijie, Ye, Chao, Yang, Xianqing, Mu, Yuguang

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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin by Fu, Afu, Ma, Shijun, Wei, Na, Tan, Blanche Xiao Xuan, Tan, Ern Yu, Luo, Kathy Qian

“…Specific siRNA-mediated MnSOD knockdown reversed all three phenotypes. Our findings therefore suggest that MnSOD plays an important integrative role in supporting cancer cell survival in circulation, metastasis, and doxorubicin resistance. …”
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Integrated analysis of the Plasmodium species transcriptome by Hoo, Regina, Zhu, Lei, Amaladoss, Anburaj, Mok, Sachel, Natalang, Onguma, Lapp, Stacey A., Hu, Guangan, Liew, Kingsley, Galinski, Mary R., Bozdech, Zbynek, Preiser, Peter Rainer

“…However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. …”
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Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…In addition to kinases, we examined the therapeutic potential of the FDA-approved hypertension drug, losartan. Losartan ameliorated the acidic store Ca²⁺ defect, which characterizes NPC, and all downstream pathologies as well as in combination with miglustat reduced levels of neuroinflammation in the mouse model. …”

Evaluating the rediscovery process as a treatment programme for a range of substance use disorders by Parker, Phil

“…No effect on outcomes was seen in the different referral routes for all analysed measures, at all time points, with the exception of impulsivity at 1month and QOL at 3-month. …”
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An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore by Ang, Li Wei, Ng, Oon Tek, Boudville, Irving Charles, Leo, Yee Sin, Wong, Chen Seong

“…The most common metabolic abnormality among PLHIV was HDL hypocholesterolemia (60.2%) followed by hypertriglyceridemia (45.5%). Of all the 2,231 individuals, 68.8% had at least one component of MetS. …”
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Percutaneous Intratumoral Immunoadjuvant Gel Increases the Abscopal Effect of Cryoablation for Checkpoint Inhibitor Resistant Cancer by Som, Avik, Rosenboom, Jan‐Georg, Wehrenberg‐Klee, Eric, Chandler, Alana, Ndakwah, Gabrielle, Chen, Eric, Suggs, Jack, Morimoto, Joshua, Kim, Jonathan, Mustafa, Abdul Rehman, Marcos‐Vidal, Asier, Fintelmann, Florian J., Basu, Arijit, Langer, Robert, Traverso, Giovanni, Mahmood, Umar

“…Its ability to significantly augment the abscopal rate of cryoablation is demonstrated in otherwise immunotherapy resistant metastatic tumors in two aggressive colorectal and breast cancer dual tumor models with an all or nothing response, responders generally demonstrating complete regression of bilateral tumors in 90‐day survival studies.…”
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Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1 by Li, Yan, Pillay, Shubhadra, Frolova, Ludmila, Pervushin, Konstantin, Wong, Leo E.

“…The precise mechanism of stop codon discrimination by eRF1 remains obscure, hindering drug development targeting aberrations at translation termination. …”
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SemFunSim : a new method for measuring disease similarity by integrating semantic and gene functional association by Cheng, Liang, Li, Jie, Ju, Peng, Peng, Jiajie, Wang, Yadong

“…This indicates that SemFunSim is an effective method for drug repositioning.…”
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Lipid-coated hybrid nanoparticles for enhanced bacterial biofilm penetration and antibiofilm efficacy by Lee, Hiang Wee, Kharel, Sharad, Loo, Joachim Say Chye

“…Up to 80% of all infections are biofilm-mediated and they are often challenging to treat as the underlying bacterial cells can become 100- to 1000-fold more tolerant toward antibiotics. …”
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Small but prospective: development of enzyme-responsive small molecule fluorescent probes for specific bacterial imaging by Yan, Evelias Hui Xin

“…Owing to the evolving pathogenicity of bacteria, whereby more drug-resistant bacteria has been emerging and bacteria developing their own defense mechanism, traditional antimicrobial approaches like antibiotics treatment have been clinically ineffective. …”
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Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin by Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng

“…We show that luteolin inhibits the replication of all four serotypes of dengue virus, but the selectivity of the inhibition was weak. …”
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