Assessing the permeability of supersaturating drug delivery system of amorphous drug-polyelectrolyte/protein nanoplexes in Caco-2 cell monolayer by Tran, The-Thien, Cheow, Wean Sin, Chua, Angeline, Yang, Guang, Poenar, Daniel Puiu, Hadinoto, Kunn

“…The present work evaluated the membrane permeability of amorphous drug-polyelectrolyte/drug-protein nanoplexes across Caco-2 cell monolayer in comparison to the native drugs. …”
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Drug interaction between acetyltanshinone IIA and rapamycin in breast cancer cells by Wong, De Pin

“…In this project, the objective is to investigate the synergistic potential between two anti breast cancer agent, rapamycin and acetyltanshinone IIA (ATA) in breast cancer cells. MTT assay was performed to test for the growth inhibitory effect of individual drugs and their combinations. …”
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Defining proteoform-specific interactions for drug targeting in a native cell signalling environment by Lutomski, CA, Bennett, JL, El-Baba, TJ, Wu, D, Hinkle, JD, Burnap, SA, Liko, I, Mullen, C, Syka, JEP, Struwe, WB, Robinson, CV

“…Understanding the dynamics of membrane protein–ligand interactions within a native lipid bilayer is a major goal for drug discovery. Typically, cell-based assays are used, however, they are often blind to the effects of protein modifications. …”

Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Mitotic slippage describes a phenomenon where cells escape mitotic arrest and cell death following treatment with anti-mitotic drugs, and "slip" into interphase without proper chromosome segregation and cytokinesis. …”
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Computational cell fate modelling for discovery of rewiring in apoptotic network for enhanced cancer drug sensitivity by Chua, Huey Eng, Zhang, Fan, Zheng, Jie, Mishra, Shital Kumar, Bhowmick, Sourav Saha

“…Here we propose a hybrid modelling approach based on ordinary differential equation (ODE) and machine learning to map network rewiring in the apoptotic pathways that may be responsible for the increase of drug sensitivity of tumour cells in triple-negative breast cancer. …”
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Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs by Liu, Xili, Moscvin, Maria, Oh, Seungeun, Chen, Tianzeng, Choi, Wonshik, Evans, Benjamin, Rowell, Sean M., Nadeem, Omar, Mo, Clifton C., Sperling, Adam S., Anderson, Kenneth C., Yaqoob, Zahid, Bianchi, Giada, Sung, Yongjin

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Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells by Head, Sarah A., Shi, Wei, Zhao, Liang, Gorshkov, Kirill, Pasunooti, Kalyan, Chen, Yue, Deng, Zhiyou, Li, Ruo-jing, Shim, Joong Sup, Tan, Wenzhi, Hartung, Thomas, Zhang, Jin, Zhao, Yingming, Colombini, Marco, Liu, Jun O.

“…Itraconazole, a clinically used antifungal drug, was found to possess potent antiangiogenic and anticancer activity that is unique among the azole antifungals. …”
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Deep graph contrastive learning model for drug-drug interaction prediction by Jiang, Zhenyu, Gong, Zhi, Dai, Xiaopeng, Zhang, Hongyan, Ding, Pingjian, Shen, Cong

“…Drug-drug interaction (DDI) is the combined effects of multiple drugs taken together, which can either enhance or reduce each other's efficacy. …”
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Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…Here, we report that the whole-tumor cell culture (WTC) ex vivo model could be stably established from all breast tumors with a high success rate (98 out of 116), and it could reassemble the parental tumors with the endogenous microenvironment. …”
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Exploring the roles of mitochondrial-associated microRNAs of head and neck cancer stem cells in drug resistance and tumor recurrence by Zhu, Xiaoning, Subha, Sethu Thakachy, Fong, Voon Hoong, Tan, Wee Lin, Cheah, Yoke Kqueen

“…The primary clinical issues in HNC are drug resistance and tumor recurrence attributed to the presence of cancer stem cells (CSCs). …”
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Triggered drug release and enhanced drug transport from ultrasound-responsive nanoparticles by Kwan, JJ, Coussios, CC

“…Conventional systemic drug therapy across all drug classes does not adequately provide safe and efficacious treatment for a broad range of fatal diseases. …”

Towards Health Centered Drug Policy: An Analysis of Past and Developing Drug Policy by Lewis, Benjamin B.

“…Drug criminalization has disproportionately impacted communities of color and has insufficiently addressed substance use disorder and its associated risk of death through overdosing. …”
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A bilayer swellable drug-eluting ureteric stent : localized drug delivery to treat urothelial diseases by Lim, Wei Shan, Chen, Kenneth, Chong, Tsung Wen, Xiong, Gordon Minru, Birch, William R., Pan, Jisheng, Lee, Bae Hoon, Er, Pei Shan, Salvekar, Abhijit Vijay, Venkatraman, Subbu S., Huang, Yingying

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Microneedles for diagnosis and therapeutic drug monitoring by Thean, Jia Hui

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The effect of rare-earth nanoparticles on drug delivery by Li, Linda Shi Wen

“…We evaluated the results of live/dead assay and confirmed the killing capacity of the drug-loaded nanoparticle. Our cell cycle analysis also showed that the drug-loaded nanoparticles reduced cell replication by arresting the cells in the G1 phase.…”
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Evaluation of drug reproductive toxicity and the underlying mechanisms by Wu, Sixian, Shang, Lijun, Xu, Wenming

“…It is also necessary to explain the mechanism of drug toxicity in drug-induced infertility. Therefore, this chapter will describe the mechanisms involved in male germ cell and somatic cell toxicity and summarize the current advanced techniques for assessing drug toxicity and analysing the mechanism of drug toxicity.…”

Evaluation of drug reproductive toxicity and the underlying mechanisms by Wu, Sixian, Shang, Lijun, Xu, Wenming

“…It is also necessary to explain the mechanism of drug toxicity in drug-induced infertility. Therefore, this chapter will describe the mechanisms involved in male germ cell and somatic cell toxicity and summarize the current advanced techniques for assessing drug toxicity and analysing the mechanism of drug toxicity.…”
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Nanosized silica particles for achiral drug separation by Tan, Timothy Thatt Yang.

“…It is widely recognized that the full potential of rapid chromatography can be realized with very small support particulates and tailor-made chiral stationary phase. …”
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Targeting the cytochrome oxidases for drug development in mycobacteria by Lee, Bei Shi, Sviriaeva, Ekaterina, Pethe, Kevin

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Drug-eluting scaffolds for bone and cartilage regeneration by Lee, Wei Li, Loo, Say Chye Joachim, Huang, Charlotte L.

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