Sustained delivery of timolol maleate from liposomal nanocarriers by Ong, Leonard Chin Hui

“…Liposomes were prepared using thin film hydration and average particle size in the range of around 100 nm was prepared using a bench top extruder and drug was actively loaded by ammonium sulphate gradient loading technique. …”
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Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…Second, we leveraged the rapidly expanding set of biosynthetic probes of the mycobacterial cell wall to rapidly characterize intracellular distances between distinct layers of the cell wall in Mycobacterium tuberculosis model organisms Corynebacterium glutamicum and Mycobacterium smegmatis using fluorescence resonance energy transfer. …”
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Antimicrobial efficacy testing of antibiotic-containing biodegradable nanopolymers against biofilm and planktonic cells. by Polimyr Caesar Dave Pelisco Dingal.

“…With efficient use of drug-encapsulated nanopolymers, bactericidal dosages are sufficiently lowered and dosing intervals can be extended due to the sustained drug release feature afforded by these efficacious nanocarriers.…”
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Utilizing food waste and thermoplastic starch (TPS) in 3D printed PLA formulations for sustainable and customizable controlled delivery systems by Wang, Liwen

“…With the addition of TPS, the drug release profile can be adjusted from 8 – 120 hours using different TPS ratios and different printed wall thicknesses. …”
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Investigation of phenylpropanoid sucrose esters as antidiabetic compounds by Wong, Kathy Pooi Wen

“…Since hybrid 77 is a systemic drug, dosing of the compound would have to account for both the rate at which it is transported across the gut wall and its toxicity. …”
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Construction and characterization of a Lactococcus lactis in-trans surface display system harboring murine glycosylated tyrosinase related protein-2 by Kalyanasundram, Jeevanathan

“…The Generally Regarded as Safe (GRAS) status of LAB such as Lactococcus lactis coupled with non-recombinant strategy of in-trans surface display system, provide a safe platform for therapeutic drug and vaccine development. However, therapeutic proteins fused with cell-wall anchoring motif production are predominantly limited to prokaryotic expression system. …”
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Cloud Spark Cluster to analyse English prescription big data for NHS intelligence by Fernando, Sandra, Sowinski-Mydlarz, Viktor, Virdee, Bal Singh

“…This study illustrates regions as well as GP practices in terms of reimbursement cost, drug consumption level, the type of the drug, and the disease type; varied demand for dispensed chemical substances over the years; shows what diseases have increased or decreased over the years as well as the total cost and its trends.…”
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Factors affecting trans-scleral transport of poly (butadiene-b-ethylene oxide) polymersomes by Anita, Vincent

“…In this light, this research work examines the suitability of polymersomes for ocular drug delivery via periocular route of drug administration. …”
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A biodegradable ocular implant for long-term suppression of intraocular pressure by Ng, Xu Wen, Liu, Kerh Lin, Veluchamy, Amutha Barathi, Lwin, Nyein Chan, Wong, Tina T., Venkatraman, Subbu Subramanian

“…However, the topical mode of administration (eyedrops) is far from optimal because of the issues of low bioavailability, high drug wastage, and lack of patient compliance. Suboptimal control of the IOP leads to disease progression and eventually to blindness. …”
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Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy by Goh, Wei Jiang, Lee, Choon Keong, Zou, Shui, Woon, Esther, Czarny, Bertrand, Pastorin, Giorgia

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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

“…In drug combination experiments targeting co-mutated pathways, I show that some degree of tolerance to GM-TKI is explained by oncogenic co-mutations, but not across all lines. …”
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Enhancing breast cancer treatment: investigating the influence of polymer ratios on Luteolin-loaded TPGS/poloxamer micelles by Mod Razif, Muhammad Redza Fahmi, Liew, Kai Bin, Chan, Siok Yee, Chew, Yik Ling, Hassan, Masriana, Ahmad Hisham, Shairyzah, Abdul Rahman, Shamima, Kee, Phei Er

“…This study aimed to optimize luteolin-loaded TPGS/Pol micelles developed using the film hydration method, followed by lyophilization. …”
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Ion doping behavior of stöber silica-nanosynthesis and application by Song, Xiaohui

“…Besides, we can dope positive charged organic molecules inside silica nanoparticle, such as dyes, drugs, and so on. The above synthesis control is important to silica application in biosensors, drug delivery, catalysts, and battery. …”
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Formulation, optimization and characterization of palm kernel oil esters nanoemulsion system containing sodium diclofenac by Rezaee, Malahat

“…All terpenes showed promoting effect on sodium diclofenac penetration. …”
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Thermal effects on particle deposition in microchannels by Yan, Zhibin

“…Transport and interactions of colloidal particles and biomolecules in microchannels are of great importance to many microfluidic applications, such as drug delivery in life science, microscale heat exchangers in electronic cooling, food processing industry etc. …”
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Graphene oxide nanoplatelets potentiate anticancer effect of cisplatin in human lung cancer cells by Nur Farhanah Rosli, Fojtů, Michaela, Fisher, Adrian C., Pumera, Martin

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Understanding the viral protein structures of clinically relevant arboviruses and fragment-based screening for antivirals by Farhana Abu Bakar

“…In recent years, antiviral drug discovery has increasingly relied on the use of high-resolution structural information of important viral proteins and have led to the development of potent inhibitors. …”
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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil by Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär

“…The screen selected accurately for all the tested known drugs acting on TS. We also identified TS inhibitors with novel chemistry and marketed drugs that were not previously known to target TS, including the DNA methyltransferase inhibitor decitabine. …”
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Design, simulation, and testing of a low cost laser micromachining system for flexible and rapid tissue-on-chip fabrication. by Nin, Jorge A.

“…With fabrication times of 6-8 minutes for small features and less than an hour for a full chip, our method represents a significant advancement in rapid prototyping capabilities. …”
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Continuous, high-throughput production of artemisinin-loaded supramolecular cochleates using simple off-the-shelf flow focusing device by Shuddhodana, Wong, Kathy Pooi Wen, Judeh, Zaher

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