Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…Furthermore, coupled with genomic and transcriptomic analyses, WTC-based testing can also help to stratify specific patient groups for assignment into appropriate clinical trials, as well as validate potential biomarkers during drug development.…”
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New multi-target based therapeutics against an opportunistic superbug by Premkumar, Jayaraman.

“…Taken together, it is imperative to discover more potent drugs and novel therapeutic strategies to combat the infections caused by this superbug. …”
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Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…The studies described in this thesis were undertaken to evaluate the application of paper spray mass spectrometry for direct analysis of small molecule drugs and biomarker in dried matrix spot samples. …”
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Janus particle preparation through UV-induced partial photodegradation of spin-coated particle films by Tan, Jasmine Si Jia, Wong, Chong Hui, Chen, Zhong

“…Photocatalytic titanium dioxide particles prefunctionalized with a surface coating were assembled as particle films via spin-coating on a substrate. The particle films were placed directly under an ultraviolet light source, which induced the photodegradation of the surface coating only on the particle surfaces exposed to the light. …”
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Glass box and black box machine learning approaches to exploit compositional descriptors of molecules in drug discovery and aid the medicinal chemist by Robson, B, Cooper, R

“…The synthetic medicinal chemist plays a vital role in drug discovery. Today there are AI tools to guide next syntheses, but many are “Black Boxes” (BB). …”

Critical test of the beneficial consequences of lifting the ban on direct-to-consumer advertising for prescription drugs in Italy: experimental exposure and questionnaire study by Schulz, Peter Johannes, Crosignani, Francesca, Petrocchi, Serena

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Amorphous ternary nanoparticle complex of curcumin-chitosan-hypromellose exhibiting built-in solubility enhancement and physical stability of curcumin by Wong, Jerome Jie Long, Lim, Li Ming, Tran, The-Thien, Wang, Danping, Cheow, Wean Sin, Hadinoto, Kunn

“…The low aqueous solubility of curcumin (CUR) had greatly limited the clinical efficacy of CUR therapy despite its well-known potent therapeutic activities. Previously, we developed amorphous nanoparticle complex (nanoplex) of CUR and chitosan (CHI) as a solubility enhancement strategy of CUR by electrostatically-driven drug-polyelectrolyte complexation. …”
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Spatially controlled molecular encapsulation in natural pine pollen microcapsules by Prabhakar, Arun Kumar, Potroz, Michael G., Park, Soohyun, Miyako, Eijiro, Cho, Nam-Joon

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BSACI guidance for the implementation of Palforzia® peanut oral immunotherapy in the United Kingdom: a Delphi consensus study by Marrs, Tom, Patel, Nandinee, Burrell, Sarah, Rampersad, Anjali, Minshall, Eleanor, Leech, Susan, Chandratilleke, Dinusha, Dempsey, Justine, Ludman, Sian, Roberts, Graham, Michaelis, Louise Jane, Brough, Helen A., Karanam, Surendra, Batt, Rebecca, Moulsdale, Phoebe, Steifel, Gary, Tiwana, Kiran, Smith, Helen, Knight, Katherine, Vazquez-Ortiz, Marta, Vyas, Deepan, Turner, Paul J., Makwana, Nick

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‘When I open it, I have to drink it all’: push and pull factors shaping domestic alcohol consumption during the COVID-19 pandemic UK Spring 2020 lockdown by Conroy, Dom, Nicholls, Emily

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Identifying antifungal resistance mechanisms and modes of action using SAturated Transposon Analysis in Yeast (SATAY) by Karadzas, M

“…These screens reveal antifungal drug targets, transporters responsible for drug uptake or efflux, as well as metabolic, signalling and trafficking pathways affecting antifungal susceptibility. …”

Mechanistic insights on protein aggregation and phase separation by Casablancas Antràs, V

Loopholes. by Li, Yvonne Meini., Law, Georgina Wan Yi., Phua, Geraldine Soo Yee.

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Investigating graph neural networks and classical feature-extraction techniques in activity-cliff and molecular property prediction by Dablander, MF

“…</p> <p>In this thesis, we systematically explore and further develop classical as well as graph-based molecular featurisation methods for two important tasks: the well-studied problem of molecular property prediction, in particular quantitative structure-activity relationship (QSAR) prediction, and the largely unexplored challenge of activity-cliff (AC) prediction. …”

Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens by Karavasili, Christina, Babaee, Sahab, Kutty, Shruti, Chu, Jacqueline N., Min, Seokkee, Fitzgerald, Nina, Morimoto, Joshua, Inverardi, Nicoletta, Traverso, Giovanni

“…To fill the existing gap in drug dose personalization and simplification of complex medication regimens commonly encountered in the treatment of cardiovascular disease, tuberculosis, and tapering of corticosteroid therapy, a modular titratable polypill approach that simultaneously addresses both aspects is proposed. …”
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Ellipsometry studies on anodic aluminium oxide (AAO)growth mechanism on high purity aluminium plate by Lim, Leng Khoon

“…In the biomedical field, AAO was used many applications such as pathogens microfiltration, biomolecules quantification, drug delivery etc, However, it had been a challenge to produce the necessary microstructure for all the mentioned applications. …”
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Ion doping behavior of stöber silica-nanosynthesis and application by Song, Xiaohui

“…The research work presented in this thesis focused on the fundamental study of nanostructure synthesis, such as the colloidal synthesis control, the hollowing behavior mechanism study, the fabrication control, the silica or polymer shell coating control, polymerization control, as well as primary application based on the mechanism study, such as the transition metal doping control, the porosity control, as well as the drug loading control in core-shell nanostructures. …”
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Sustained delivery of timolol maleate from liposomal nanocarriers by Ong, Leonard Chin Hui

“…Liposomes were prepared using thin film hydration and average particle size in the range of around 100 nm was prepared using a bench top extruder and drug was actively loaded by ammonium sulphate gradient loading technique. …”
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Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…Second, we leveraged the rapidly expanding set of biosynthetic probes of the mycobacterial cell wall to rapidly characterize intracellular distances between distinct layers of the cell wall in Mycobacterium tuberculosis model organisms Corynebacterium glutamicum and Mycobacterium smegmatis using fluorescence resonance energy transfer. …”
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Fabrication and characterization of hydrogel nanoparticles by Chen, Xiao Wei

“…This is to study how different sizes and stiffness will affect the cellular uptake as well as the effectiveness of the fabricated drugs. …”
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