High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin by Fu, Afu, Ma, Shijun, Wei, Na, Tan, Blanche Xiao Xuan, Tan, Ern Yu, Luo, Kathy Qian

“…Understanding the survival mechanism of metastatic cancer cells in circulation will provide new perspectives on metastasis prevention and also shed new light on metastasis-derived drug resistance. …”
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Synthesis, Characterisation Of Stilbene–Arylcinnamide Hybrids And Cytotoxic Studies Against Lung Cancer Cell A549 by Mohd Zaki, Nurain Syazwani

“…The cytotoxicity against human lung cancer A549 cell line was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay, using cisplatin as the positive control. …”
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Phytochemical analysis and cytotoxic effects of mango (Mangifera indica L) kernel on breast cancer cell lines by Abdullah, Al-Shwyeh Hussah

“…The cytotoxicity ofthe extract on breast cancer MDA-MB-231 and MCF-7 cells and normal breast MCF-10A cells was assessed by neutral red uptake, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, and lactate dehydrogenase release assays and morphological studies, using doxorubicin as the control. …”
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Synthesis, characterization and in vitro evaluation of novel enantiomerically-pure sulphonamide antimalarials by Anusha, Sebastian, Sinha, Ameya, Babu Rajeev, C. P., Chu, Trang T. T., Mathai, Jessin, Huang, Ximei, Fuchs, Julian E., Shivananju, NanjundaSwamy, Bender, Andreas, Preiser, Peter Rainer, Rangappa, Kanchugarakoppal S., Basappa, Chandramohanadas, Rajesh

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Single cell hydrodynamic stretching and microsieve filtration reveal genetic, phenotypic and treatment-related links to cellular deformability by Li, Fenfang, Cima, Igor, Vo, Jess Honganh, Tan, Min-Han, Ohl, Claus-Dieter

“…We also find that the drug docetaxel leads to an increase in the size of A549 lung cancer cells. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Generally, Gram-negative bacterial pathogens have additional outer membranes mainly composed of highly conserved and unique lipopolysaccharide (LPS) molecules, which serve as permeability barriers to prevent the cell bodies from toxic antimicrobial molecules1-2 including many photosensitizers, which have been successfully used in photoinactivation of Gram-positive strains.3-4 Furthermore, LPS, a potent inducer to human innate immune systems, hence called endotoxin, is now primarily responsible for sepsis associated with the infections of Gram-negative pethogens.5-6 Therefore, the most promising strategy is use of LPS neutralizing peptide as the binding ligand to deliver antibacterial agents meanwhile minimize the side effects.7 The first objective of the research in part I is the design and synthesis of photosensitizer-peptide conjugates for multivalent targeted cellular imaging and photodynamic inactivation (PDI) against Gram-negative bacterial strains. …”
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Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy by Volpatti, Lisa R, Bochenek, Matthew A, Facklam, Amanda L, Burns, Delaney M, MacIsaac, Corina, Morgart, Alexander, Walters, Benjamin, Langer, Robert, Anderson, Daniel G

“…For islet cell transplantation, 1.5 mm capsules comprised of a blend of unoxidized and 2.5% oxidized alginate maintain cell viability and glycemic control over a period of more than 2 months while reducing the volume of nondegradable material implanted. …”
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The potential of fluocinolone acetonide to mitigate inflammation and lipid accumulation in 2D and 3D foam cell cultures by Nguyen, Luong T. H., Muktabar, Aristo, Tang, Jinkai, Wong, Yee Shan, Thaxton, Colby S., Venkatraman, Subbu Subramanian, Ng, Kee Woei

“…Inflammation plays an important role in all stages of atherosclerosis development. Therefore, the use of anti-inflammatory drugs could reduce the risk of major adverse cardiovascular events due to atherosclerosis. …”
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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Osoti, V, Wamae, K, Ndwiga, L, Gichuki, PM, Okoyo, C, Kepha, S, Keitany, K, Kandie, R, Aricha, S, Kiplagat, R, Mwandawiro, C, Bejon, P, Snow, RW, Ochola-Oyier, LI

“…The Pfdhfr 51I and 108 N pyrimethamine-resistance mutations were at fixation (100% frequency), and the Pfmdr1 Y184F mutation, which is linked to reduced susceptibility to several antimalarial drugs, especially those used in combination therapies for malaria treatment, was detected in 97.5% of the samples as mixed-genotype infections. …”

Mechanistic insights on protein aggregation and phase separation by Casablancas Antràs, V

Cationic glycosylated block co-β-peptide acts on the cell wall of Gram-positive bacteria as anti-biofilm agents by Zhang, Kaixi, Raju, Cheerlavancha, Zhong, Wenbin, Pethe, Kevin, Gründling, Angelika, Chan-Park, Mary B.

“…In addition to the emergence of resistance to last resort drugs, bacteria escape antibiotics killing by forming complex biofilms. …”
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Cytotoxicity and mechanisms of action of Zerumbone-loaded nanostructured lipid carrier in triple negative breast cancer cells, MDA-MB-231 by Hosseinpour, Mahnaz

“…Mode of cell death was determined by microscopic observation of AO/PI double stained cells, annexin-V, TUNEL, caspases assays and cell cycle analysis. …”
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Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells by Wijianto, Diski Wahyu, Sri Wahyuni, Arifah, Wardani, Rizkiananda, Nugraheni, Ambar Yunita, Abu Bakar, Fazleen Izzany

“…The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells.…”
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Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.

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Insights on the characteristics and therapeutic potential of mesenchymal stem cell-derived exosomes for mitigation of Alzheimer’s disease’s pathogenicity: a systematic review by Mohammed Yousuf Abdi, Sarah, Mustaffa Al-Bakri, Siti Sarah, Nordin, Norshariza

“…Treatment of AD relies on administering drugs that only subside the symptoms. In recent studies, mesenchymal stem cell (MSC)-exosomes have been marked to possess therapeutic potential for treating AD. …”

Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer by Akıncılar, Semih Can, Chua, Joelle Yi Heng, Ng, Qin Feng, Chan, Claire Hian Tzer, Eslami-S, Zahra, Chen, Kaijing, Low, Joo-Leng, Arumugam, Surendar, Aswad, Luay, Chua, Clarinda, Tan, Iain Beehuat, DasGupta, Ramanuj, Fullwood, Melissa Jane, Tergaonkar, Vinay

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A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype by Ahmad, F

“…The isolated rod-shaped cells were electrically quiescent unless stimulated to fire action potentials with an amplitude of 100 mV from a resting potential of approximately -70 mV. …”

In vitro anti-proliferative mechanism of combination therapy with tannic acid and cisplatin against human osteosarcoma cell line U2OS by Kasiram, Mohamad Zahid Mohd

“…The percentage of apoptotic cells was measured using flow cytometer after conducting annexin V/propidium iodide (PI) assay. …”
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G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells by Liao, C, Long, Y, Tsai, M, Lin, C, Hsu, K, Lee, C

“…Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess autophagy activity often pose invasiveness and time-related constraints, limiting their applicability in preclinical drug investigations. …”

RES.10-001 Making Science and Engineering Pictures, Fall 2014 by Frankel, Felice C.

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