Impact of pyridyl moieties on the inhibitory properties of prominent acyclic metal chelators against metallo-β-lactamase-producing Enterobacteriaceae : investigating the molecular... by Sosibo, Sphelele C., Somboro, Anou M., Amoako, Daniel G., Osei Sekyere, John, Bester, Linda A., Ngila, Jane C., Sun, Darren Delai, Kumalo, Hezekiel M.

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Improving access to pulmonary rehabilitation for patients with COPD treated for substance misuse in the London Borough of Islington by Narasimhan, Divya, Simpson, Jane, Stewart, Duncan

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Barriers and leverage points for seeing alcohol differently in integrated care systems in England: a senior stakeholder interview study by Madden, Mary, Stewart, Duncan, McCambridge, Jim

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Blood brain barrier: a tissue engineered microfluidic chip by Musafargani, Sikkandhar, Mishra, Sachin, Gulyás, Miklós, Mahalakshmi, P., Archunan, Govindaraju, Padmanabhan, Parasuraman, Gulyás, Balázs

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Development of immunomodulatory RNA therapeutics for immune disorders by Iyer, Vaishnavi Srinivasan

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Clinical sub-phenotypes of Staphylococcus aureus bacteraemia by Swets, MC, Bakk, Z, Westgeest, AC, Berry, K, Cooper, G, Sim, W, Lee, RS, Gan, TY, Donlon, W, Besu, A, Heppenstall, E, Tysall, L, Dewar, S, de Boer, M, Fowler, VG, Dockrell, DH, Thwaites, GE, Pujol, M, Pallarès, N, Tebé, C, Carratalà, J, Szubert, A, Groeneveld, GH, Russell, CD

“…</p> <br> <p><Strong>Results:</strong> Included patients had predominantly methicillin-susceptible SAB (1366/1430,95.5%). We identified five distinct, reproducible clinical sub-phenotypes: (A) SAB associated with older age and comorbidity, (B) nosocomial intravenous catheter-associated SAB in younger people without comorbidity, (C) community-acquired metastatic SAB, (D) SAB associated with chronic kidney disease, and (E) SAB associated with injection drug use. …”

Investigation of phenylpropanoid sucrose esters as antidiabetic compounds by Wong, Kathy Pooi Wen

“…Alpha glucosidase inhibitors (AGIs) are a class of anti-diabetic drug known for their effectiveness and safety. However, they are associated with gastrointestinal (GI) side-effects such as diarrhoea, nausea and flatulence. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…Hence, development of a broad range anti-IAV drug that could target all of the IAV strains irrespective of their source is critically important. …”
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Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study... by Dyson, ZA, Ashton, PM, Khanam, F, Chunga Chirambo, A, Shakya, M, Meiring, JE, Tonks, S, Karkey, A, Msefula, C, Clemens, JD, Dunstan, SJ, Baker, S, Dougan, G, Pitzer, VE, Basnyat, B, Qadri, F, Heyderman, RS, Gordon, MA, Holt, KE, Pollard, AJ, STRATAA Study Group

“…Azithromycin-resistance mutations in acrB were rare, appearing only in Dhaka (five [1%] of 452). Phylogenetic analyses showed that most cases derived from pre-existing, locally established pathogen variants; 702 (98%) of 713 drug-resistant infections resulted from local circulation of AMR variants, not imported variants or recent de novo emergence; and pathogen variants circulated across age groups. 479 (66%) of 731 cases clustered with others that were indistinguishable by point mutations; individual clusters included multiple age groups and persisted for up to 2·3 years, and AMR determinants were invariant within clusters.…”

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Kupffer cell–mediated cytokine release recapitulated an in vivo proinflammatory response exemplified by a cohort of 11 cytokines that were differentially regulated after lipopolysaccharide induction, including interleukin (IL)-1β, IL-1Ra, IL-6, IL-8, IP-10, tumor necrosis factor-α, RANTES (regulated on activation normal T cell expressed and secreted), granulocyte colony-stimulating factor, macrophage colony-stimulating factor, macrophage inflammatory protein-1β, and IL-5. In summary, our findings indicate that three-dimensional liver microphysiological systems may serve as preclinical investigational platforms from the perspective of the discovery of a set of clinically relevant biomarkers including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.…”
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The effects of different solubilizing agents on the transport and pharmacokinetic profiles of indomethacin: in vitro and in vivo approach by Siti Aisyah Zainuddin, Abdul Latip Ab Hamid, Aqila Iman Rafandi, Mashani Mohamad, Khuriah Abdul Hamid, Syed Haroon Khalid

“…Solubilizing agents, including propylene glycol, Transcutol P, Labrasol, PEG 400, and Tween 80, were separately added at 10% (v/v) to 1 mg/5 mL for in vitro diffusion chamber and 10 mg/kg body weight for in vivo oral absorption studies of indomethacin. …”
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Anti-leukaemic and chemotherapy supportive effects of berberis vulgaris l. Fruit crude extract on in vitro and in vivo models by Saedi, Tayebeh Azam

“…The disease is characterized by increasing of immature white blood cells called "blasts", and is estimated to account for about 3% of incident cases for all kind of cancer worldwide. …”
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Investigation of Synthetic Proteins Produced via Automated Fast-Flow Peptide Synthesis by Cowfer, Amanda Elizabeth

“…I will discuss the iterative steps my team took to vary both chemical and mechanical and control variables to improve per-coupling yield enough to enable access to full-length single-domain proteins. On this journey, we utilized test peptides to validate synthesis quality and later synthesized a suite of full-length single-domain biologically active proteins. …”
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nCVTs : a hybrid smart tumour targeting platform by Goh, Wei Jiang, Zou, Shui, Czarny, Bertrand, Pastorin, Giorgia

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A grid-based HIV expert system by Sloot, Peter M. A., Boukhanovsky, Alexander V., Boucher, Charles A. B., Keulen, Wilco.

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Linking dual mode of action of host defense antimicrobial peptide thanatin: structures, lipopolysaccharide and LptAm binding of designed analogs by Sinha, Sheetal, Dhanabal, Vidhya Bharathi, Sperandeo, Paola, Polissi, Alessandra, Bhattacharjya, Surajit

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Design and in vitro release study of siRNA loaded Layer by Layer nanoparticles with sustained gene silencing effect by Tan, Yang Fei, Lee, Ying Shi, Seet, Li-Fong, Ng, Kee Woei, Wong, Tina T., Venkatraman, Subbu

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The IDentif.AI-x pandemic readiness platform: rapid prioritization of optimized COVID-19 combination therapy regimens by Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C., Wong, John Eu-Li, Tan, Gladys Gek-Yen, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean

“…IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). …”
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Delay-and-pay: prolonging pharmaceutical patent protection without paying the ‘price’ by Foss-Solbrekk, K

Psychotropic taxonomies: constructing a therapeutic framework for psychiatry by McCutcheon, RA, Cowen, P, Nour, MM, Pillinger, T