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Investigation of phenylpropanoid sucrose esters as antidiabetic compounds
Published 2020“…Alpha glucosidase inhibitors (AGIs) are a class of anti-diabetic drug known for their effectiveness and safety. However, they are associated with gastrointestinal (GI) side-effects such as diarrhoea, nausea and flatulence. …”
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Thesis-Doctor of Philosophy -
84
The treatment of malaria in pregnancy
Published 2001“…Studies are urgently needed to define the best therapeutic options and to develop new treatments, especially in Africa where drug resistance already compromises all strategies of control.…”
Book section -
85
Blood brain barrier: a tissue engineered microfluidic chip
Published 2022Get full text
Journal Article -
86
Delay-and-pay: prolonging pharmaceutical patent protection without paying the ‘price’
Published 2024“…<p>This thesis argues that actors use the patent system as part of a ‘delay-and-pay’ strategy to preserve drug prices for as long as possible by delaying generic/biosimilar market entry – and that they have a significant incentive to do so. …”
Thesis -
87
Investigation of Synthetic Proteins Produced via Automated Fast-Flow Peptide Synthesis
Published 2024“…I will discuss the iterative steps my team took to vary both chemical and mechanical and control variables to improve per-coupling yield enough to enable access to full-length single-domain proteins. On this journey, we utilized test peptides to validate synthesis quality and later synthesized a suite of full-length single-domain biologically active proteins. …”
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Thesis -
88
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Design and in vitro release study of siRNA loaded Layer by Layer nanoparticles with sustained gene silencing effect
Published 2020Get full text
Journal Article -
90
Layer-by-layer polyelectrolyte coated erythrocyte carriers
Published 2011“…This report shows the need to improve the process due to the increased interest in using carrier erythrocytes as drug delivery system. The erythrocytes coated with a polyelectrolyte multilayer provide a simple mean for controlling the burst and subsequent release of bioactive agents. …”
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Final Year Project (FYP) -
91
Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses)
Published 2017“…Hence, development of a broad range anti-IAV drug that could target all of the IAV strains irrespective of their source is critically important. …”
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Thesis-Doctor of Philosophy -
92
Anti-leukaemic and chemotherapy supportive effects of berberis vulgaris l. Fruit crude extract on in vitro and in vivo models
Published 2015“…All data were analyzed using one-way ANOVA followed by Duncan's multiple post hoc tests. …”
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Thesis -
93
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94
Antimicrobial photodynamic therapy for the remote eradication of bacteria
Published 2023Get full text
Journal Article -
95
Utilizing food waste and thermoplastic starch (TPS) in 3D printed PLA formulations for sustainable and customizable controlled delivery systems
Published 2024“…With the addition of TPS, the drug release profile can be adjusted from 8 – 120 hours using different TPS ratios and different printed wall thicknesses. …”
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Thesis-Master by Research -
96
Translation termination mechanism studied by solution state NMR
Published 2012“…In eukaryotes, class-I release factor (eRF1) directly recognizes all three stop-codons in the A site on the small ribosomal subunit and stimulates peptide release. …”
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Thesis -
97
Automated sample preparation systems for medical diagnostics
Published 2014“…At the heart of all these applications is the procedure of sample preparation to extract nucleic acids of interest from organisms for subsequent analyses. …”
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Thesis -
98
European biologic training course for type 2 inflammation by EUFOREA in 2024: key facts and lessons learned
Published 2024“…EUFOREA is an international non-for-profit organization forming an alliance of all stakeholders dedicated to reducing the prevalence and burden of chronic respiratory diseases through the implementation of optimal patient care via educational, research, and advocacy activities. …”
Journal article -
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Synthesis of densely functionalized pyrroles from unprotected carbohydrates
Published 2023“…The activity of pyrrole-based drugs is tuned with the type of substituents on the pyrrole core and on the substitution pattern on the core pyrrole ring. …”
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Thesis-Doctor of Philosophy