Metformin degradation with combined Ozone/UV/H2O2 process by Fujinami, Shoko Carissa

“…Metformin is a commonly used drug to treat Type 2 diabetic patients. As the number of diabetic patients globally has increased from 108 million in 1980 to 422 million in 2014, it can be seen that diabetes is a common form of illness and in Singapore, there is about 1 in 10 people suffering from diabetes (Lai, 2015). …”
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Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis by Tan, Bryan, Pan, Xin-Hui, Chew, Jocelyn Han Shi, Goh, Rachel Sze Jen, Lin, Chaoxing, Anand, Vickram Vijay, Lee, Ethan Cheng Zhe, Chan, Kai En, Kong, Gwyneth, Ong, Christen En Ya, Chung, Charlotte Hui, Young, Dan Yock, Chan, Mark Y., Khoo, Chin Meng, Mehta, Anurag, Muthiah, Mark Dhinesh, Noureddin, Mazen, Ng, Cheng Han, Chew, Nicholas W. S., Chin, Yip Han

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Effect of metabolite and temperature on artificial human sweat characteristics over a very wide frequency range (400 MHz–10.4 GHz) for wireless hydration diagnostic sensors by Lubangakene, Innocent, Virdee, Bal Singh, Jayanthi, Renu, Ganguly, Priyanka

“…As a result, analysis of electrolytes in this biofluid is gaining traction in the development of non-invasive sweat diagnostics to determine level of dehydration, cystic fibrosis and illicit drugs. This paper presents a wireless measurement modality of permittivity properties of sweat of different metabolite concentration levels exemplifying the full spectrum of human sweat. …”
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Combined ultrasound and photoacoustic imaging of blood clot during microbubble-assisted sonothrombolysis by Das, Dhiman, Pramanik, Manojit

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The role of tumour necrosis factor alpha stimulated gene-6 on bone by Afrough, S

“…Depending on the severity of the disease, most patients are often treated with calcium/vitamin D and anti-resorptive drugs such as bisphosphonates or calcitonin. However, there are few options for bone formation using anabolic agents- such as Teriparatide (PTH_1-34), which have limited success, creating an unmet need for novel anabolic interventions.…”

Dopamine Nation : Finding Balance in the Age of Indulgence / by Lembke, Anna, Dr., author 655980, Penguin Publishing Group (Online service) 655981

“…Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. …”
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The development and application of fish scale waste for tissue engineering applications : waste-to-resource conversion of resource resilient materials by Wang, Jun Kit

“…Overall, SHCol-conjugated PVDF films demonstrated better hemocompatibility properties as compared to other fish species, and thus is a promising material to be used for blood contacting applications. …”
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Resistant hypertension and mortality: an observational cohort study by de la Sierra, A, Ruilope, LM, Staplin, N, Gorostidi, M, Vinyoles, E, Segura, J, Armario, P, Oliveras, A, Williams, B

“…<p><strong>Methods</strong></p> We selected 8146 patients with controlled hypertension (office BP &lt;140/90 mm Hg while being treated with ≤3 antihypertensive drugs) and 8577 with resistant hypertension (BP ≥140 or ≥90 mm Hg while being treated with ≥3 drugs). …”

Protein delivery options: how well have we succeeded? by Ng, Xu Wen, Subbu, Venkatraman

“…Of the ten top-selling drugs in 2013, the first three (Humira®, Enbrel®, Remicade®) were all monoclonal antibodies for treating autoimmune diseases; together these three accounted for approximately $28 billion in sales. …”
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Detection of single-nucleotide polymorphisms in Plasmodium falciparum by PCR primer extension and lateral flow immunoassay by Moers, APHA, Hallett, R, Burrow, R, Schallig, HDFH, Sutherland, CJ, van Amerongen, A

“…The resistance of Plasmodium falciparum to some antimalarial drugs is linked to single-nucleotide polymorphisms (SNPs). …”

建立知识经济时代的竞争优势 = Building the competitive advantage in the knowledge economy : an analysis of the added-value of the intellectual capital of Xian-Janssen from the knowledge manageme... by 李一敏 Li, Yimin

“…"Xian-Janssen Pharmaceutical Ltd", as the No.1 leading pharmaceutical JV in China, is a successful model among all.…”
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RES.LL-005 D4M: Signal Processing on Databases, Fall 2012 by Kepner, Jeremy

“…Search, social media, ad placement, mapping, tracking, spam filtering, fraud detection, wireless communication, drug discovery, and bioinformatics all attempt to find items of interest in vast quantities of data. …”
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Mechanism of damnacanthal induced apoptosis in CEM-SS cell line by Gopalsamy, Banulata, Saiful Yazan, Latifah, Abdul Hamid, Hisyam

“…Due to the harsh effects of currently used cancer drugs, damnacanthal, an anthraquinone obtained from the roots of Morinda elliptica is tested as a potential anticancer agent. …”
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Structural and mechanistic studies of herpes virus proteins by Patel, Vidhi Kanaiyalal

“…Herpes Simplex Viruses (HSV) 1 and 2 are the most prevalent amongst the eight known human herpes viruses (HHV). All herpes viruses have a characteristic life cycle, divided into latent and lytic phases. …”
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Biointerface design for vertical nanoprobes by Elnathan, Roey, Barbato, Maria Grazia, Guo, Xiangfu, Mariano, Anna, Wang, Zixun, Santoro, Francesca, Shi, Peng, Voelcker, Nicolas H., Xie, Xi, Young, Jennifer L., Zhao, Yunlong, Zhao, Wenting, Chiappini, Ciro

“…Vertical nanoprobes have substantially improved our ability to control and characterize the intracellular environment, guide biophysical stimuli with nanoscale precision to defined cell compartments, stimulate and record the electrical activity of cells, and transport hard-to-deliver drugs. These capabilities are enabling substantial advances in bioelectronics, spatiotemporally resolved molecular diagnostics, and cell and gene therapy — all underpinned by the design versatility of the nanoprobe biointerface. …”
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Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine learning approaches by Carter, J, Walker, T, Walker, A, Whitfield, M, Morlock, G, Lynch, C, Adlard, D, Peto, T, Posey, J, Crook, D, Fowler, P

“…<p><strong>Methods</p></strong> We curated a dataset of 664 non-redundant, missense amino acid mutations in PncA with associated high-confidence phenotypes from published studies and then trained three different machine-learning models to predict pyrazinamide resistance. All models had access to a range of protein structural-, chemical- and sequence-based features. …”

The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…<p>Colorectal cancer (CRC) currently represents one of the most commonly diagnosed tumors, accounting for 10% of all cancer diagnoses and cancer-related deaths. …”

Cheaper Than A Funeral: Considering Ibogaine’s Psychedelic Journey and Therapeutic Potential by Daly, Noah

“…It is also considered the most extreme of the psychedelic drugs currently known to researchers. For the past fifty years, it’s been used to treat severe substance use disorders, particularly with highly addictive opioids and stimulants. …”
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Nickel-catalyzed enantioselective reductive arylation and heteroarylation of aldimines via an elementary 1,4-addition by Zhang, Luoqiang, Wang, Xiuhua, Pu, Maoping, Chen, Caiyou, Yang, Peng, Wu, Yun-Dong, Chi, Robin Yonggui, Zhou, Steve Jianrong

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Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes by Zarei, Mohammad, Barroso, Emma, Palomer, Xavier, Escolà-Gil, Joan Carles, Cedó, Lidia, Wahli, Walter, Vázquez-Carrera, Manuel

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