Deep graph contrastive learning model for drug-drug interaction prediction by Jiang, Zhenyu, Gong, Zhi, Dai, Xiaopeng, Zhang, Hongyan, Ding, Pingjian, Shen, Cong

“…Drug-drug interaction (DDI) is the combined effects of multiple drugs taken together, which can either enhance or reduce each other's efficacy. …”
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Triggered drug release and enhanced drug transport from ultrasound-responsive nanoparticles by Kwan, JJ, Coussios, CC

“…Conventional systemic drug therapy across all drug classes does not adequately provide safe and efficacious treatment for a broad range of fatal diseases. …”

Towards Health Centered Drug Policy: An Analysis of Past and Developing Drug Policy by Lewis, Benjamin B.

“…Drug criminalization has disproportionately impacted communities of color and has insufficiently addressed substance use disorder and its associated risk of death through overdosing. …”
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A bilayer swellable drug-eluting ureteric stent : localized drug delivery to treat urothelial diseases by Lim, Wei Shan, Chen, Kenneth, Chong, Tsung Wen, Xiong, Gordon Minru, Birch, William R., Pan, Jisheng, Lee, Bae Hoon, Er, Pei Shan, Salvekar, Abhijit Vijay, Venkatraman, Subbu S., Huang, Yingying

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Assessing the permeability of supersaturating drug delivery system of amorphous drug-polyelectrolyte/protein nanoplexes in Caco-2 cell monolayer by Tran, The-Thien, Cheow, Wean Sin, Chua, Angeline, Yang, Guang, Poenar, Daniel Puiu, Hadinoto, Kunn

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Targeting the cytochrome oxidases for drug development in mycobacteria by Lee, Bei Shi, Sviriaeva, Ekaterina, Pethe, Kevin

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18F-labelling of new chemotypes for drug discovery by Khotavivattana, T

“…Finally, Chapter 5 gives full experimental procedures and characterisation data for all compounds.</p>…”

Amplifying signals in the tumor microenvironment for drug development and diagnostics by Martin Alonso, Maria Carmen

“…Leveraging advancements in high throughput screening and in deep learning, we contribute important tools for the effective design of conditional drugs that require the cleavage of a protease substrate to unleash drug cytotoxicity. …”
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Exploring TNFi drug-levels and anti-drug antibodies during tapering among patients with inflammatory arthritis: secondary analyses from the randomised BIODOPT trial by Uhrenholt, L, Sørensen, MER, Lauridsen, KB, Duch, K, Dreyer, L, Christensen, R, Hauge, E-M, Loft, AG, Rasch, MNB, Horn, HC, Taylor, PC, Nielsen, KR, Kristensen, S

“…ADAb were detected in eight patients, all from the tapering group. TNFi drug-level category or ADAb were not predictive for achieving successful tapering at 18 months. …”

Toxicity, permeability and drug-metabolizing enzyme activities of curcumin analogues by Yakubu, Ndatsu

“…The results of the apparent permeability coefficient (Papp) in Caco-2 cells after 120 min incubation and their absorption (uptake) rates in adult male zebrafish after 4 hr suggested that MS65>BDMC33>EF-24>curcumin. The activities of drug-metabolizing enzymes (CPR,UGT, GST and SULT) in cells and adult male zebrafish subjected to all test compounds, separately, as compared to that of normal cells and zebrafish demonstrated that MS65 is better than BDMC33, followed by EF-24 and then curcumin. …”
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Assignment optimization of pandemic influenza antiviral drugs in Urban pharmacies by Zhang, Chijun, Du, Zhanwei, Cai, Qing, Yu, Limin, Li, Zhaohui, Bai, Yuan

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Liposomal carrier systems for encapsulation of drugs using bicellar mixtures by Lee, Bao Jun

“…Drug delivery systems can be in the form of particles in which the drug is protected by a core material that is biocompatible with the body. …”
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Adverse health events associated with antipsychotic use: an umbrella review by Chow, RTS

Expediting treatments in the 21st century: orphan drugs and accelerated approvals by Domike, Reuben, Raju, G. K., Sullivan, Jamie, Kennedy, Annie

“…In 1983, the United States Congress passed the Orphan Drug Act to provide financial incentives for development of drugs for rare diseases. …”
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Novel drug-eluting stent to reduce fibrosis-induced ureteral stricture by Fong, Timothy Ren Zhong

“…The aim of this project is to synthesize a drug loaded coating with smooth morphology and identify the effect of thickness, drug loading and pH on the sustained release of MMC. …”
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Temporal pressure enhanced topical drug delivery through micropore formation by Lio, Daniel Chin Shiuan, Chia, Ruining, Kwek, Milton Sheng Yi, Wiraja, Christian, Madden, Leigh Edward, Chang, Hao, S. Mohideen Abdul Khadir, Wang, Xiaomeng, Becker, David Lawrence, Xu, Chenjie

“…However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). …”
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From the body to the brain: Studying drug delivery and physiological interactions using MRI by Dawson, Miranda

“…In all, this work serves as a demonstration of the power of quantitative neuroimaging methods for multifaceted investigation of brain and body relationships.…”
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Hollow microcapsules as periocular drug depot for sustained release of anti-VEGF protein by Radhakrishnan, Krishna, Vincent, Anita, Joseph, Rini Rachel, Moreno, Miguel, Dickescheid, Andreas, Agrawal, Rupesh, Venkatraman, Subbu S.

“…Diseases affecting the posterior segment of the eye such as age-related macular degeneration and diabetic retinopathy are leading causes of blindness all over the world. The current treatment regimen for such diseases involves repeated intravitreal injections of anti- Vascular Endothelial Growth Factor (VEGF) proteins. …”
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Near-infrared light for phototherapy : photothermal induced drug release and tumor ablation by Li, Menghuan

“…The lessons learnt from the dual responsive core/shell drug nanocarrier proved substantial, which offered useful insights for the shaping of a new NIR responsive drug delivery system. …”
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Characterizing the conformational landscape of MDM2-binding p53 peptides using molecular dynamics simulations by Yadahalli, Shilpa, Li, Jianguo, Lane, David P., Gosavi, Shachi, Verma, Chandra Shekhar

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