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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin
Published 2017“…Understanding the survival mechanism of metastatic cancer cells in circulation will provide new perspectives on metastasis prevention and also shed new light on metastasis-derived drug resistance. In this study, we made it feasible to detect apoptosis of circulating tumor cells (CTCs) in real-time by integrating a fluorescence resonance energy transfer (FRET)-based caspase sensor into one in vitro microfluidic circulatory system, and two in vivo models: zebrafish circulation and mouse lung metastatic model. …”
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Journal Article -
203
Polymeric composites for powder-based additive manufacturing : materials and applications
Published 2020Get full text
Journal Article -
204
Niemann-Pick type c disease: pathogenesis and therapy
Published 2016“…In addition to kinases, we examined the therapeutic potential of the FDA-approved hypertension drug, losartan. Losartan ameliorated the acidic store Ca<sup>2+</sup> defect, which characterizes NPC, and all downstream pathologies as well as in combination with miglustat reduced levels of neuroinflammation in the mouse model. …”
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Assessing the impact of a sport for development and peace intervention on the mental and physical health of adolescents in Mullaitivu, Sri Lanka
Published 2016“…</p> <p><b>Discussion:</b></p> <p>Successive rounds of field reliability tests improved the measurement protocols. I was able to draw limited conclusions about the impact of the intervention as it was implemented to a negligible degree, and the study was underpowered due to absenteeism. …”
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Lipid-coated hybrid nanoparticles for enhanced bacterial biofilm penetration and antibiofilm efficacy
Published 2023“…Antibiotic-loaded nanoparticles have gained traction as a potential drug delivery system to treat biofilm infections. …”
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Journal Article -
208
Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1
Published 2014“…The precise mechanism of stop codon discrimination by eRF1 remains obscure, hindering drug development targeting aberrations at translation termination. …”
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Journal Article -
209
Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin
Published 2017“…We show that luteolin inhibits the replication of all four serotypes of dengue virus, but the selectivity of the inhibition was weak. …”
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Journal Article -
210
21W.730-4 Writing and the Environment, Fall 2002
Published 2002“…The first paper of the term will draw upon personal experience; the others will require a modest amount of research. …”
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Learning Object -
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Percutaneous Intratumoral Immunoadjuvant Gel Increases the Abscopal Effect of Cryoablation for Checkpoint Inhibitor Resistant Cancer
Published 2024“…The poly‐lactic‐<jats:italic>co</jats:italic>‐glycolic acid‐polyethylene glycol‐poly‐lactic‐<jats:italic>co</jats:italic>‐glycolic acid (PLGA‐PEG‐PLGA)‐based amphiphilic copolymer gel's underlying micellar nature enables high drug concentration and a logarithmic release profile that is additive with the neo‐antigen release from cryoablation, requiring only a single injection. …”
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212
SemFunSim : a new method for measuring disease similarity by integrating semantic and gene functional association
Published 2014“…This indicates that SemFunSim is an effective method for drug repositioning.…”
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213
Maximizing dissimilarity in resting state detects heterogeneous subtypes in healthy population associated with high substance use and problems in antisocial personality
Published 2021“…We compared the scores of 69 behavioral measures and found six behaviors related to the use of marijuana, illicit drugs, alcohol, and tobacco; and including a measure of antisocial personality to differentiate the two groups. …”
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214
Small but prospective: development of enzyme-responsive small molecule fluorescent probes for specific bacterial imaging
Published 2024“…Owing to the evolving pathogenicity of bacteria, whereby more drug-resistant bacteria has been emerging and bacteria developing their own defense mechanism, traditional antimicrobial approaches like antibiotics treatment have been clinically ineffective. …”
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Thesis-Master by Research -
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Evaluating the rediscovery process as a treatment programme for a range of substance use disorders
Published 2019“…No effect on outcomes was seen in the different referral routes for all analysed measures, at all time points, with the exception of impulsivity at 1month and QOL at 3-month. …”
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216
An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore
Published 2021“…In view of the progressive aging of HIV-infected population and long-term use of cART, regular monitoring for metabolic abnormalities, surveillance of drug effects and behavioural interventions are needed to optimize management and prevention of metabolic disorders in PLHIV.…”
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217
Aircraft noise, overheating and poor air quality in London primary schools' classrooms
Published 2012“…The overall findings of this thesis have been developed to draw the attention of school designers' to the current and future potential conflicts between the comfort factors in schools' classrooms. …”
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Renal-clearable molecular probe for near-infrared fluorescence imaging and urinalysis of SARS-CoV-2
Published 2022Get full text
Journal Article