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121
Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents
Published 2024“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”
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122
Real‐time imaging of dynamic cell reprogramming with nanosensors
Published 2020Get full text
Journal Article -
123
Membrane reconstitution of monoamine oxidase enzymes on supported lipid bilayers
Published 2020Get full text
Journal Article -
124
Peptide asparaginyl ligases—renegade peptide bond makers
Published 2021Get full text
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Structure and subunit arrangement of Mycobacterial F1FO ATP synthase and novel features of the unique mycobacterial subunit δ
Published 2020“…The arrangement of δ relative to the N-termini of the catalytic α3β3-headpiece and its potential as a drug target are discussed.…”
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Journal Article -
128
Polymeric composites for powder-based additive manufacturing : materials and applications
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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin
Published 2017“…Specific siRNA-mediated MnSOD knockdown reversed all three phenotypes. Our findings therefore suggest that MnSOD plays an important integrative role in supporting cancer cell survival in circulation, metastasis, and doxorubicin resistance. …”
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Journal Article -
134
Integrated analysis of the Plasmodium species transcriptome
Published 2018“…However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. …”
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Journal Article -
135
Niemann-Pick type c disease: pathogenesis and therapy
Published 2016“…In addition to kinases, we examined the therapeutic potential of the FDA-approved hypertension drug, losartan. Losartan ameliorated the acidic store Ca<sup>2+</sup> defect, which characterizes NPC, and all downstream pathologies as well as in combination with miglustat reduced levels of neuroinflammation in the mouse model. …”
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Multi-scale and multiphase modeling of abrasive flow machining process with experimental validation
Published 2023“…Here, the study established all the simulations using complex shape for surface and basic to complex shapes for the particle. …”
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Thesis-Doctor of Philosophy -
138
Evaluating the rediscovery process as a treatment programme for a range of substance use disorders
Published 2019“…No effect on outcomes was seen in the different referral routes for all analysed measures, at all time points, with the exception of impulsivity at 1month and QOL at 3-month. …”
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Thesis -
139
An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore
Published 2021“…The most common metabolic abnormality among PLHIV was HDL hypocholesterolemia (60.2%) followed by hypertriglyceridemia (45.5%). Of all the 2,231 individuals, 68.8% had at least one component of MetS. …”
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Journal Article -
140
Percutaneous Intratumoral Immunoadjuvant Gel Increases the Abscopal Effect of Cryoablation for Checkpoint Inhibitor Resistant Cancer
Published 2024“…Its ability to significantly augment the abscopal rate of cryoablation is demonstrated in otherwise immunotherapy resistant metastatic tumors in two aggressive colorectal and breast cancer dual tumor models with an all or nothing response, responders generally demonstrating complete regression of bilateral tumors in 90‐day survival studies.…”
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