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Transdermal Drug Delivery
Published 2016“…As each drugs have different molecular properties, operation parameters are varied accordingly. …”
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Final Year Project (FYP) -
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Investigating viral glycosylation pathways for drug and vaccine development
Published 2021“…</p> <p>The current COVID-19 pandemic has highlighted the urgent need for vaccines and antiviral drugs. The principal topic of my DPhil centres on addressing these needs for viral infection. …”
Thesis -
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Deep learning methods for genome-based prediction of drug resistance in Mycobacterium tuberculosis
Published 2023“…Recent years have seen a concerning rise in drug-resistant tuberculosis cases, calling for the development of new approaches for drug susceptibility testing. …”
Thesis -
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A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria
Published 2024“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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Journal Article -
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Identifying antifungal resistance mechanisms and modes of action using SAturated Transposon Analysis in Yeast (SATAY)
Published 2024“…These screens reveal antifungal drug targets, transporters responsible for drug uptake or efflux, as well as metabolic, signalling and trafficking pathways affecting antifungal susceptibility. …”
Thesis -
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo...
Published 2014“…In part II, my first project is the development of novel drug-loaded nanogels for pH sensitive drug release, which will be described in chapter 3. …”
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Thesis -
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RES.10-001 Making Science and Engineering Pictures, Fall 2014
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Learning Object -
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Targeting NAPE-PLD: assessing its potential in the fight against malaria
Published 2024“…Malaria remains a major global challenge with increasing artemisinin-resistant Plasmodium falciparum. This calls for an increased need for discovering novel ring-stage drug targets. …”
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Final Year Project (FYP) -
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Titanium–aluminum–polytetrafluoroethylene coated stainless steel micromold via co-sputtering deposition : replication performance and limitation in hot-embossing
Published 2013“…The sputtering power applied to the PTFE target was varied to control the PTFE concentration in the Ti–Al–PTFE coatings, which affected the bonding structure, surface roughness, friction and contact angle of coatings characterized using micro-Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), confocal microscopy, ball-on-disc tribometer and goniometer, respectively. …”
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Journal Article -
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Functionalized microwell laser sorting method for single-cell viable microbial detection
Published 2024“…Additionally, it integrated bright-field, fluorescence, and Raman identification methods to enhance specificity for microbial detection. …”
Journal article -
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Development of red/near-infrared fluorescent molecules and macromolecules for biomedical applications
Published 2017“…The hydrophobic layer of side chain was used to physically entrap drugs for chemotherapy. To address the potential problem of drug leakage, we utilized amphiphilic random copolymers containing drug-modified units as side chain of conjugated polymers instead in Chapter 7. …”
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Thesis -
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Inclusions in calcite phantom crystals suggest role of clay minerals in dolomite formation
Published 2022“…Micro- and nano-inclusions embedded in calcite phantom crystals from Gemerská Ves, Slovak Republic, have been characterized by a combination of Raman spectroscopy, scanning and transmission electron microscopy, X-ray powder difraction, and C and O isotope analysis. …”
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Journal Article -
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Inhibition of endoplasmic reticulum stress using 4-phenyl butyrate mitigates osteoporosis in a mouse model of hindlimb suspension
Published 2024“…Humeri, femora, and tibiae bones were collected and cleaned from soft tissues for measurements of reactive oxygen species (ROS) levels, histomorphometry, micro-CT, Raman spectroscopy, and gene expression studies. …”
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Thesis -
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Development and Application of a Data-Driven Signal Detection Method for Surveillance of Adverse Event Variability Across Manufacturing Lots of Biologics
Published 2023“…We propose a data-driven signal detection method called HMMScan to monitor for manufacturing lot-dependent changes in adverse event (AE) rates, and herein apply it to a biologic drug. …”
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Antimicrobial efficacy testing of antibiotic-containing biodegradable nanopolymers against biofilm and planktonic cells.
Published 2009“…With efficient use of drug-encapsulated nanopolymers, bactericidal dosages are sufficiently lowered and dosing intervals can be extended due to the sustained drug release feature afforded by these efficacious nanocarriers.…”
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Final Year Project (FYP) -
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Physicochemical and in-vitro release studies of liponanocapsules
Published 2012“…The objective of this project is to optimize and study the formulation of stable polyelectrolyte coated liposomes called liponanocapsules. They are formed using the layer-by-layer (lbl) technique. …”
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Final Year Project (FYP) -
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G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells
Published 2024“…Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess autophagy activity often pose invasiveness and time-related constraints, limiting their applicability in preclinical drug investigations. …”
Journal article