Hollow microcapsules as periocular drug depot for sustained release of anti-VEGF protein by Radhakrishnan, Krishna, Vincent, Anita, Joseph, Rini Rachel, Moreno, Miguel, Dickescheid, Andreas, Agrawal, Rupesh, Venkatraman, Subbu S.

“…Diseases affecting the posterior segment of the eye such as age-related macular degeneration and diabetic retinopathy are leading causes of blindness all over the world. The current treatment regimen for such diseases involves repeated intravitreal injections of anti- Vascular Endothelial Growth Factor (VEGF) proteins. …”
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A novel fabrication method for submicron hydrogel particles loaded with protein drug by Philips Laulia

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Deep learning methods for genome-based prediction of drug resistance in Mycobacterium tuberculosis by Wang, C

“…Recent years have seen a concerning rise in drug-resistant tuberculosis cases, calling for the development of new approaches for drug susceptibility testing. …”

Investigating novel drug delivery systems to enhance tissue regeneration in the central nervous system by Lin, Vincent Po Hen

“…However, the presence of multiple cell types in the CNS tissues may lead to nonspecific uptake and reduced efficiency in drug delivery. …”
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Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain by Platt, MA

“…The aims of this project were to synthesise and evaluate a series of bivalent TRIM24 chemical tools in order to investigate the effects of inhibiting <em>both</em> the PHD and BRD on breast cancer cells.</p> <br> <p>Given the close proximity of the PHD and BRD, and lack of TRIM24 PHD ligands, it was decided that a TRIM24 BRD ligand would be linked to a H3-mimicking peptide containing a KMe₃ isostere, to generate bivalent peptide-drug conjugates (PDCs) (Figure 0.1a). …”

Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…<p>The urgent need to improve therapies for people with drug-resistant epilepsy (DRE) requires improved understanding of the aetiopathophysiology of epilepsy and the mechanisms responsible for pharmacoresistance. …”

Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy by Leylek, Ozen, Honeywell, Megan E., Lee, Michael J., Hemann, Michael T., Ozcan, Gulnihal

“…We validated the synergy in cell death using fluorescence-based and lysis-dependent inference of cell death kinetics assay, and validated the genetic dependencies by single-gene knockout experiments. …”
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Development and in vitro bioevaluation of cockle shell-calcium carbonate (Aragonite) nanoparticles for intracellular drug delivery by Isa, Tijani

“…Fourier transforms infrared (FT-IR) spectra shows evident of interactions exist between the drug and nanoparticles at the molecular level. No burst effect, but a sustained drug release was observed from the formulation. …”
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An iGlu receptor antagonist and its simultaneous use with an anticancer drug for cancer therapy by Luo, Zhong, Li, Peizhou, Tan, Si Yu, Ang, Chung Yen, Nguyen, Kim Truc, Zhao, Yanli

“…The present work demonstrated the feasibility of employing a delivery system to deliver both neuroprotective drug and anticancer drug for efficient anticancer treatment.…”
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Characterizing the conformational landscape of MDM2-binding p53 peptides using molecular dynamics simulations by Yadahalli, Shilpa, Li, Jianguo, Lane, David P., Gosavi, Shachi, Verma, Chandra Shekhar

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Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome by Dziekan, Jerzy Michal, Wirjanata, Grennady, Dai, Lingyun, Go, Ka Diam, Yu, Han, Lim, Yan Ting, Chen, Liyan, Wang, Loo Chien, Puspita, Brenda, Prabhu, Nayana, Sobota, Radoslaw M., Nordlund, Pär, Bozdech, Zbynek

“…Despite decades of research, little is known about the cellular targets and the mode of action of the vast majority of antimalarial drugs. We recently demonstrated that the cellular thermal shift assay (CETSA) protocol in its two variants: the melt curve and the isothermal dose-response, represents a comprehensive strategy for the identification of antimalarial drug targets. …”
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Neutralizing antibodies against plasmodium falciparum associated with successful cure after drug therapy by Goh, Yun Shan, Peng, Kaitian, Chia, Wan Ni, Siau, Anthony, Chotivanich, Kesinee, Gruner, Anne-Charlotte, Preiser, Peter, Mayxay, Mayfong, Pukrittayakamee, Sasithon, Sriprawat, Kanlaya, Nosten, Francois, White, Nicholas J., Renia, Laurent

“…An effective antibody response can assist drug treatment to contribute to better parasite clearance in malaria patients. …”
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Application of variational graph encoders as an effective generalist algorithm in computer-aided drug design by Lam, Hilbert Yuen In, Pincket, Robbe, Han, Hao, Ong, Xing Er, Wang, Zechen, Hinks, Jamie, Wei, Yanjie, Li, Weifeng, Zheng, Liangzhen, Mu, Yuguang

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A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen

“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing by Neupane, Yub Raj, Handral, Harish K., Syed Abdullah Alkaff, Chng, Wei Heng, Venkatesan, Gopalakrishnan, Huang, Chenyuan, Lee, Choon Keong, Wang, Jiong-Wei, Sriram, Gopu, Dienzo, Rhonnie Austria, Lu, Wen Feng, Yusuf Ali, Czarny, Bertrand, Pastorin, Giorgia

“…Recently, extracellular vesicles (EVs), naturally cell-secreted lipid membrane-bound vesicles laden with biological cargos including proteins, lipids, and nucleic acids, have drawn wide attention due to their ability to promote wound healing and tissue regeneration. …”
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Boronic acid and nitrofuranyl derivatives as potential therapeutics by Dey, AL

“…‘Rule of 5’, there has been extensive research on lead-like compounds other than those in the realm of small molecule drug-likeness. With this borne in mind Chapter 1, Antimicrobial Peptides – a New Chasm, introduces the concept of protein-protein interactions (PPIs), which could pave the way for development of promising therapeutic agents of various properties such as pacidamycin and muraymycin which are all peptide-based antibiotics that are concerned with PPIs. …”

A bilayer swellable drug-eluting stent for the treatment of fibrosis-induced ureteral stricture recurrence by Lim, Wei Shan

“…An in-vitro transwell cell study showed that the drug eluted from the coated stent was able to inhibit human bladder stroma fibroblasts (HBdSF) in-vitro.To better understand the effect of hydrogel on drug release and transfer of BSDES, the release study of BSDES was conducted in both in-vitro dynamic fluid flow and porcine ureteric tissue ex-vivo dynamic fluid flow condition. …”
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Computational screening of FDA-approved hepatitis c drugs for inhibition of VEGFR2 in liver cancer by Roney, Miah, Issahaku, Abdul Rashid, Tufail, Nasir, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Furthermore, these compounds were then subjected to molecular dynamic simulation, principle component analysis, and MMGBSA using the AMBER20 software, and the results showed stable complexes compared to the control complex. All things considered, this study will help the scientific community and society find a novel drug to treat LC.…”
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Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India by Kaza, P, Xavier, BB, Mahindroo, J, Singh, N, Baker, S, Nguyen, TNT, Mavuduru, RS, Mohan, B, Taneja, N

“…Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. …”

Inhalable biomimetic nanomotor for pulmonary thrombus therapy by Zhang, Kai, Long, Yuying, Li, Shuting, Zhao, Yanli, Han, Heyou

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