Targeted therapy to gastric cancer by Hou, Qian.

“…Unlike drugs that target specific kinases, the 8 drugs identified here indirectly inhibit multiple signaling pathways which are essential for cancer cell survival. …”
Get full text

A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications by Chen, Xiao, Li, Hua, Lam, King-Yeung

“…The electrical and pH response characteristics of the hydrogel, especially those in neutral solution, may inspire some potential biomedical applications, such as photo-controlled drug release and cell growth.…”
Get full text

Development of new methods in membrane protein science : tools in aquaporin-based research by To, Janet Yiu Ying

“…Aquaporins are a family of small, integral membrane proteins which facilitate water transport across the plasma membrane of cells in response to osmotic gradients. Since the discovery of these water channels more than 20 years ago, there has been an encouraging advancement in the understanding of their structural and functional roles in human physiology, in particular in water balance disorders, and in cell migration and angiogenesis. …”
Get full text

Smart Microfluidic Devices for Point-Of-Care Applications by Julee Choudhary, Birendra Kumar, Durai, Sundararajan Ananiah, Ahmad, Nabihah

“…Additionally, its day-by-day research studies on drug discovery, cell sorting, and manipulation enrich bio-medical applications. …”
Get full text

Smart Microfluidic Devices for Point-Of-Care Applications by Julee Choudhary, Birendra Kumar, Durai, Sundararajan Ananiah, Ahmad, Nabihah

“…Additionally, its day-by-day research studies on drug discovery, cell sorting, and manipulation enrich bio-medical applications. …”
Get full text

Investigating the genetics and immunopathogenesis of ankylosing spondylitis by Liu, F

“…I hypothesized that studying the common genetic risks among AS and its associated conditions could help prioritize risk genes as potential drug targets and reveal potential opportunities for drug repurposing. …”

Developing a novel approach to map signals required for GalNAcT2 relocation. by Tan, Wei Ling.

“…Glycosylation is an important post-translational modification as it has multiple biological functions like cell-cell communications and cell-matrix interactions. …”
Get full text

Blood brain barrier: a tissue engineered microfluidic chip by Musafargani, Sikkandhar, Mishra, Sachin, Gulyás, Miklós, Mahalakshmi, P., Archunan, Govindaraju, Padmanabhan, Parasuraman, Gulyás, Balázs

“…Yet, the efficacious delivery of drug across blood-brain barrier (BBB) remains a formidable challenge. …”
Get full text

Next generation electrolytes for sodium ion battery by Do, Minh Phuong

“…Following, the relation of anion core structures, functional groups and cations to essential physicochemical properties had been drawn. For thermal safety, IL-based full cell Na0.6Mn0.9Co0.1O2/Na2.55V6O16 is capable to operate at elevated temperature and safer than organic-based cell in calorimetry tests with lower onset temperature and self-heating rate. …”
Get full text

Ig.n.is. by Ong, Jian'an.

“…The topic I am addressing is this mysterious phenomenon that we call Fire. It has permeated the fabric of our everyday lives, right from the beginning of its discovery, its domestication to the modern everyday use of its properties. …”
Get full text

Factors affecting trans-scleral transport of poly (butadiene-b-ethylene oxide) polymersomes by Anita, Vincent

“…In this light, this research work examines the suitability of polymersomes for ocular drug delivery via periocular route of drug administration. …”
Get full text

Design and in vitro release study of siRNA loaded Layer by Layer nanoparticles with sustained gene silencing effect by Tan, Yang Fei, Lee, Ying Shi, Seet, Li-Fong, Ng, Kee Woei, Wong, Tina T., Venkatraman, Subbu

Get full text

Ultrasound-compatible 3D-printed Franz diffusion system for sonophoresis with microbubbles by Chen, Xin, De Grandi, Davide, Zhu, Yonglian, Lutheryn, Gareth, Lane, Majella E., Sil dos Santos, Bruno, Carugo, Dario

“…Franz diffusion cells have been extensively used for measuring drug permeation in vitro; however, traditional systems lack compatibility with ultrasound and only limited characterisation of their acoustical behaviour has been carried out in previous research. …”
Get full text
Get full text

Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly by Peacock, L, Ferris, V, Sharma, R, Sunter, J, Bailey, M, Carrington, M, Gibson, W

“…Elucidating the mechanism of genetic exchange is fundamental for understanding how genes for such traits as virulence, disease phenotype, and drug resistance are transferred between pathogen strains. …”

Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities by Ding, Feiqing, Leow, Min Li, Ma, Jimei, William, Ronny, Liao, Hongze, Liu, Xue-Wei

“…Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki–Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μm. …”
Get full text
Get full text
Get full text

Mitigation of oxidative stress damage caused by abiotic stress to improve biomass yield of microalgae: a review by Zhu, Jiangyu, Cai, Yifei, Wakisaka, Minato, Yang, Zhengfei, Yin, Yongqi, Fang, Weiming, Xu, Yan, Omura, Taku, Yu, Ruihui, Zheng, Alvin Lim Teik

“…Microalgae have been recognized as emerging cell factories due to the high value-added bio-products. …”
Get full text

the other child / by Atkins, Lucy, 192824 author

“…Joe is distressed, the next-door neighbours are in crisis, and Tess is sure that someone is watching her. Greg's work is all-consuming and, as the baby's birth looms, he grows more and more unreachable. …”

Semiconducting photothermal nanoagonist for remote-controlled specific cancer therapy by Zhen, Xu, Xie, Chen, Jiang, Yuyan, Ai, Xiangzhao, Xing, Bengang, Pu, Kanyi

“…Our study thus demonstrates the first example of ion-channel-specific and remote-controlled drug-delivery system for cancer cell therapy.…”
Get full text
Get full text

Targeting NAPE-PLD: assessing its potential in the fight against malaria by Goh, Xiu Ling

“…Malaria remains a major global challenge with increasing artemisinin-resistant Plasmodium falciparum. This calls for an increased need for discovering novel ring-stage drug targets. …”
Get full text

Linking dual mode of action of host defense antimicrobial peptide thanatin: structures, lipopolysaccharide and LptAm binding of designed analogs by Sinha, Sheetal, Dhanabal, Vidhya Bharathi, Sperandeo, Paola, Polissi, Alessandra, Bhattacharjya, Surajit

“…At present, antibiotics options to cure infections caused by drug resistant Gram-negative pathogens are highly inadequate. …”
Get full text