Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes by Low, Jianrong L., Gehring, Adam J., Kranz, David M., Grotenbreg, Gijsbert M., Yau, Yin Hoe, Shochat, Susana Geifman, Bertoletti, Antonio, Naidoo, Anneta, Yeo, Gladys, Ho, Zi Zong

“…Various protein scaffolds have been designed to recapitulate the specific recognition of presented antigens with the aim to be exploited both diagnostically (e.g. to visualize cells exposed to infectious agents or cellular transformation) and therapeutically (e.g. for the delivery of drugs to compromised cells). …”
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Performance of epoxy-based self-healing mortar by Ariffin, Nur Farhayu

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Strength and compressibility of soft soil reinforced with bottom ash columns by Hasan, Muzamir

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Semi-closed circulation integrated multi-trophic aquaculture treatment system using aquatic organisms as biofilters to improve shrimp effluent quality by Lavania Baloo

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Energy efficient resource migration based load balance mechanism for high traffic applications IoT by Kumar, Sunil, Cengiz, Korhan, Vimal, Suresh, Suresh, A.

“…The performance of the proposed scheme has been validated by experimental results. Through various experiments, results are being concluded that usage of SBLB results in significant decrease in average response and reply time.…”
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To what extent and in what ways do communities of practice facilitate learning in the context of professional development for interpreting students and practitioners? by D'Hayer, Danielle

“…This lonely experience in this no man’s land induces an identity crisis and a need for further professional development that has not yet been investigated. This study explores whether the concept of Communities of Practice (CoP) within a Social Learning framework offers a collaborative approach to support the transformative trajectory of interpreting students to becoming professional interpreters engaged in the market, and to potentially bring the interpreting profession to value, nurture and care for newcomers. …”
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Young people's understanding of European values: enhancing abilities, supporting participation and voice by Ross, Alistair, Loughran, Tom, Brunold, Andreas, Hartsmar, Nanny, Liljefors Persson, Bodil, Chistolini, Sandra, Dotta, Leanete Thomas, Freires, Thiago, Kõiv, Kristi, Lopes, Juliana Crespo, Pembecioğlu, Nilüfer, Pereira, Fátima, Spinthourakis, Julia Athena

“…Understanding values has always been important. In a time when we are exposed to so many different explanations and commentaries, when social media allow and almost require instantaneous responses, that seem to have to be short, pithy, emphatic. …”
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High-spin impurities and surface acoustic waves in piezoelectric crystals for spin-lattice coupling by Magnusson, E

“…This spin system has already been identified as a high potential quantum technology component due to its long coherence time. …”

Investigating the genetics and immunopathogenesis of ankylosing spondylitis by Liu, F

“…Interestingly, PPIF, as a cyclophilin, can bind to Cyclosporin and the latter has been approved to treat IBD. The genetic risk overlapping suggested the opportunity of repurposing Cyclosporin to treat AS.…”

Agriculture and citadel in the Bronze Age Aegean: the view from western Anatolia by Maltas, T

“…In the Late Chalcolithic, potentially communal and highly visible extra-household storage may have been used to maintain cooperative relationships between small households in order to meet acute labour demands at key points in the agricultural year. …”

Acquisition of musical skills and abilities in older adults—results of 12 months of music training by Losch, H, Altenmüller, E, Marie, D, Passarotto, E, Kretschmer, CR, Scholz, DS, Kliegel, M, Krüger, THC, Sinke, C, Jünemann, K, James, CE, Worschech, F

“…Practicing a musical instrument has been identified as a promising activity for improving cognition, promoting well-being, and inducing brain plasticity in older individuals. …”

Probabilistic verification beyond context-freeness by Li, G

“…</p> <br> <p>While Markov Chains (MCs) have long been foundational tools in this field, their limitations in modelling complex, recursive systems have prompted the development of more expressive models, such as Recursive Markov Chains (RMCs) and Probabilistic Pushdown Automata (pPDAs). …”

How does gamification impact on medical students’ academic motivation towards otolaryngology, and what demographics influence this: a mixed methods study by Burr, C

“…Gamification is the “use of game design elements in non-game contexts”, and has been proposed as a pedagogy which may enhance intrinsic academic motivation. …”

The association between hip morphology parameters and 19-year risk of end-stage osteoarthritis of the hip in caucasian females: a case-control study by Nicholls, AS

“…<p>Over the past decade, measures of hip morphology have been recognised as biomechanical risk factors for the development of osteoarthritis (OA) in the hip. …”

Views and uses of sepsis / deterioration digital alerts in NHS Trusts in England: a qualitative study with healthcare professionals by Lazzarino, R, Borek, AJ, Honeyford, K, Welch, J, Brent, AJ, Kinderlerer, A, Cook, G, Patil, S, Gordon, A, Glampson, B, Goodman, P, Ghazal, P, Daniels, R, Costelloe, CE, Tonkin-Crine, S

“…To support rapid sepsis diagnosis and treatment, screening tools have been embedded into hospital digital systems to appear as digital alerts. …”

Identification of novel interactions between MicroRNAs and pattern-recognition receptor signalling in dentritic cells by Pichulik, T

“…Recent evidence has suggested that PRR signalling regulates the expression of microRNAs (miRNAs), important post-transcriptional regulators of gene expression, which have been shown to fine-tune innate immune responses.</p> <p>This thesis describes the discovery of miR-650, a novel PRR-responsive miRNA that is down regulated in monocyte-derived dendritic cells (DCs) on PRR stimulation. …”

Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, R, Tong, O, Taylor, C, Kumar Sharma, P, Verge De Los Aires, A, Mahe, E, Ruffieux, H, Nassiri, I, Middleton, M, Fairfax, B

“…For raw data, please refer to the FASTQ files which have been deposited in the European Genome–phenome Archive, which is hosted by the European Bioinformatics Institute and the Centre for Genomic Regulation (accession no. …”

Indicators of global climate change 2022: annual update of large-scale indicators of the state of the climate system and human influence by Forster, PM, Smith, CJ, Walsh, T, Lamb, WF, Lamboll, R, Hauser, M, Ribes, A, Rosen, D, Gillett, N, Palmer, MD, Rogelj, J, von Schuckmann, K, Seneviratne, SI, Trewin, B, Zhang, X, Allen, M, Andrew, R, Birt, A, Borger, A, Boyer, T, Broersma, JA, Cheng, L, Dentener, F, Friedlingstein, P, Gutiérrez, JM, Gütschow, J, Hall, B, Ishii, M, Jenkins, S, Lan, X, Lee, J-Y, Morice, C, Kadow, C, Kennedy, J, Killick, R, Minx, JC, Naik, V, Peters, GP, Pirani, A, Pongratz, J, Schleussner, C-F, Szopa, S, Thorne, P, Rohde, R, Rojas Corradi, M, Schumacher, D, Vose, R, Zickfeld, K, Masson-Delmotte, V, Zhai, P

“…Over the 2013&ndash;2022 period, human-induced warming has been increasing at an unprecedented rate of over 0.2&thinsp;^∘C per decade. …”

PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder by Wang, L

“…However, no evidence for DNA replication defects has been found in these patient-derived cells. The aim of this thesis was to determine cellular pathways that are affected by the S228I alteration and to uncover mechanisms by which PCNAS^228I cells tolerate the perturbed PCNA interactions in specific pathways. …”

Adverse health events associated with antipsychotic use: an umbrella review by Chow, RTS

“…Numerous systematic reviews have found evidence for antipsychotics’ adverse effects, but few attempts have been made to assess the robustness of these evidence. …”