Investigating the genetics and immunopathogenesis of ankylosing spondylitis by Liu, F

“…Interestingly, PPIF, as a cyclophilin, can bind to Cyclosporin and the latter has been approved to treat IBD. The genetic risk overlapping suggested the opportunity of repurposing Cyclosporin to treat AS.…”

Agriculture and citadel in the Bronze Age Aegean: the view from western Anatolia by Maltas, T

“…In the Late Chalcolithic, potentially communal and highly visible extra-household storage may have been used to maintain cooperative relationships between small households in order to meet acute labour demands at key points in the agricultural year. …”

Acquisition of musical skills and abilities in older adults—results of 12 months of music training by Losch, H, Altenmüller, E, Marie, D, Passarotto, E, Kretschmer, CR, Scholz, DS, Kliegel, M, Krüger, THC, Sinke, C, Jünemann, K, James, CE, Worschech, F

“…Practicing a musical instrument has been identified as a promising activity for improving cognition, promoting well-being, and inducing brain plasticity in older individuals. …”

Probabilistic verification beyond context-freeness by Li, G

“…</p> <br> <p>While Markov Chains (MCs) have long been foundational tools in this field, their limitations in modelling complex, recursive systems have prompted the development of more expressive models, such as Recursive Markov Chains (RMCs) and Probabilistic Pushdown Automata (pPDAs). …”

How does gamification impact on medical students’ academic motivation towards otolaryngology, and what demographics influence this: a mixed methods study by Burr, C

“…Gamification is the “use of game design elements in non-game contexts”, and has been proposed as a pedagogy which may enhance intrinsic academic motivation. …”

The association between hip morphology parameters and 19-year risk of end-stage osteoarthritis of the hip in caucasian females: a case-control study by Nicholls, AS

“…<p>Over the past decade, measures of hip morphology have been recognised as biomechanical risk factors for the development of osteoarthritis (OA) in the hip. …”

Views and uses of sepsis / deterioration digital alerts in NHS Trusts in England: a qualitative study with healthcare professionals by Lazzarino, R, Borek, AJ, Honeyford, K, Welch, J, Brent, AJ, Kinderlerer, A, Cook, G, Patil, S, Gordon, A, Glampson, B, Goodman, P, Ghazal, P, Daniels, R, Costelloe, CE, Tonkin-Crine, S

“…To support rapid sepsis diagnosis and treatment, screening tools have been embedded into hospital digital systems to appear as digital alerts. …”

Identification of novel interactions between MicroRNAs and pattern-recognition receptor signalling in dentritic cells by Pichulik, T

“…Recent evidence has suggested that PRR signalling regulates the expression of microRNAs (miRNAs), important post-transcriptional regulators of gene expression, which have been shown to fine-tune innate immune responses.</p> <p>This thesis describes the discovery of miR-650, a novel PRR-responsive miRNA that is down regulated in monocyte-derived dendritic cells (DCs) on PRR stimulation. …”

Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, R, Tong, O, Taylor, C, Kumar Sharma, P, Verge De Los Aires, A, Mahe, E, Ruffieux, H, Nassiri, I, Middleton, M, Fairfax, B

“…For raw data, please refer to the FASTQ files which have been deposited in the European Genome–phenome Archive, which is hosted by the European Bioinformatics Institute and the Centre for Genomic Regulation (accession no. …”

Indicators of global climate change 2022: annual update of large-scale indicators of the state of the climate system and human influence by Forster, PM, Smith, CJ, Walsh, T, Lamb, WF, Lamboll, R, Hauser, M, Ribes, A, Rosen, D, Gillett, N, Palmer, MD, Rogelj, J, von Schuckmann, K, Seneviratne, SI, Trewin, B, Zhang, X, Allen, M, Andrew, R, Birt, A, Borger, A, Boyer, T, Broersma, JA, Cheng, L, Dentener, F, Friedlingstein, P, Gutiérrez, JM, Gütschow, J, Hall, B, Ishii, M, Jenkins, S, Lan, X, Lee, J-Y, Morice, C, Kadow, C, Kennedy, J, Killick, R, Minx, JC, Naik, V, Peters, GP, Pirani, A, Pongratz, J, Schleussner, C-F, Szopa, S, Thorne, P, Rohde, R, Rojas Corradi, M, Schumacher, D, Vose, R, Zickfeld, K, Masson-Delmotte, V, Zhai, P

“…Over the 2013&ndash;2022 period, human-induced warming has been increasing at an unprecedented rate of over 0.2&thinsp;^∘C per decade. …”

PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder by Wang, L

“…However, no evidence for DNA replication defects has been found in these patient-derived cells. The aim of this thesis was to determine cellular pathways that are affected by the S228I alteration and to uncover mechanisms by which PCNAS^228I cells tolerate the perturbed PCNA interactions in specific pathways. …”

Adverse health events associated with antipsychotic use: an umbrella review by Chow, RTS

“…Numerous systematic reviews have found evidence for antipsychotics’ adverse effects, but few attempts have been made to assess the robustness of these evidence. …”

Large-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome by Thomma, RCM, Halstead, SK, de Koning, LC, Fehmi, J, Rinaldi, S, IGOS consortium

“…Extensive research into clinical associations of individual anti-ganglioside antibody specificities has been performed. Recent research has highlighted glycolipid complexes, glycolipid combinations that may alter antibody binding, as targets. …”

Optimization of a Luteolin-loaded Tpgs/poloxamer 407 nanomicelle: the effects of copolymers, hydration temperature and duration, and freezing temperature on encapsulation efficienc... by Mod Razif, Muhammad Redza Fahmi, Chan, Siok Yee, Widodo, Riyanto Teguh, Chew, Yik-Ling, Hassan, Masriana, Ahmad Hisham, Shairyzah, Abdul Rahman, Shamima, Ming, Long Chiau, Tan, Ching Siang, Lee, Siew-Keah, Liew, Kai Bin

“…Background: Luteolin is a flavonoid compound that has been widely studied for its various anti-cancer properties and sensitization to multidrug-resistant cells. …”
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In vitro evaluation of oral contraceptives on long-tailed macaque (Macaca fascicularis) primary ovarian cells by Muhammed, Mikail, Tengku Azizan, Tengku Rinalfi Putra, Mohd Noor, Mohd Hezmee, Abu Hassim, Hasliza, Che'Amat, Azlan, Saleh, Annas Bin, Han, Mark Hiew Wen, Ab Latip, Mohd Qayyum

“…Hormonal contraception has been advocated as an alternative population control method for the long-tailed macaque population, which has increased exponentially due to anthropogenic changes and incidental food subsidies from human food waste. …”
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A comprehensive study of laser irradiated hydrothermally synthesized 2D layered heterostructure V2O5(1−x)MoS2(x) (X = 1–5%) nanocomposites for photocatalytic application by Jameel, Muhammad Hasnain, Yasin, Aqeela, Samia, Mayzan, Mohd Zul Hilmi, Roslan, Muhammad Sufi, Esa, Fahmiruddin, Agam, Mohd Arif, Mohd Zaid, Mohd Hafiz, Althubeiti, Khaled, Aljohani, Mohammed

“…It has been studied that both two-dimensional (2D) MoS2 and V2O5, which are classified as transition metal dichalcogenides and transition metal oxides, are good photocatalyst materials. …”
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Lower desorption temperature in CO 2 capture using various magnesium oxide loading on iron(III) oxide by ultrasonic-assisted synthesis: the adsorption-desorption and isotherm studi... by Lahuri, Azizul Hakim, Jaafar, Nur Farhana, Nordin, Norazzizi, Dzakaria, Norliza, Mohd Yusof, Syawal, Samidin, Salma, Sulaiman, Syazreen Nadia, Marliza, Tengku Sharifah

“…This shows that the Fe3+ ion in the Fe2O3 structure has been successfully replaced by a smaller ion radius of Mg2+ and the ion was successfully incorporated into the Fe2O3 as a substitutional atom. …”
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ranscriptome profile and gene expression during different ovarian maturation stages of Macrobrachium rosenbergii (De Man, 1879) by Mardhiyyah, Mohd Pauzi, Zakaria, Muhammad Faiz, Amin-Safwan, Adnan, Nur-Syahirah, Mamat, Sung, Yeong Yik, Ma, Hongyu, Ikhwanuddin, Mhd

“…Despite significant interest in M. rosenbergii, its gene discovery has been at a relatively small scale compared to other genera. …”
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Identification of novel bovine leukocyte antigen alleles and association of BoLA-DRB3.2*020:02:01 with resistance to Theileria orientalis infection in crossbred Kedah-Kelantan catt... by Agina, Onyinyechukwu Ada, Shaari, Mohd Rosly, Md Isa, Nur Mahiza, Ajat, Mokrish, Zamri Saad, Mohd, Hamzah, Hazilawati

“…The bovine leukocyte antigen (BoLA) gene is a significant genetic part of the immune system and has been used as a disease marker in cattle. In this study, we detected Theileria orientalis, T. sinensis, Anaplasma marginale, Anaplasma platys, Candidatus Mycoplasma haemobos and Trypanosoma evansi by PCR amplification and sequencing of the amplicons. …”

School Management System (SPS): factors affecting school effectiveness by Wan Mahmud, Wan Marfazila, Ab.Jalil, Habibah

“…This research was done for four districts which had been chosen at random, according to the states and zones in Peninsular Malaysia including Central Zone (Petaling Perdana district, Selangor), North Zone (North East district, Penang), East Zone (Kota Bahru district, Kelantan) and South district (Johor Bahru district, Johor). …”
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