A comparison of sodium-glucose co-transporter 2 inhibitor kidney outcome trial participants with a real-world chronic kidney disease primary care population by Forbes, AK, Hinton, W, Feher, MD, Elson, W, Ordóñez-Mena, JM, Joy, M, Fan, X, Banerjee, D, Cole, NI, Munro, N, Whyte, M, Suckling, RJ, Swift, PA, de Lusignan, S

“…Trial participants were 9–14 years younger than the real-world CKD population, and had more advanced CKD, including higher levels of albuminuria. …”

Empagliflozin lowers serum uric acid in chronic kidney disease: exploratory analyses from the EMPA-KIDNEY trial by Mayne, K, Sardell, R, Staplin, N, Judge, P, Zhu, D, Sammons, E, Emberson, J, Preiss, D, Landray, M, Baigent, C, Wanner, C, Haynes, R, Herrington, W

“…<p><strong> Methods</p></strong> The EMPA-KIDNEY trial randomised 6609 patients with CKD (estimated glomerular filtration rate [eGFR] ≥20 and <90 mL/min/1.73m2 ) to receive either empagliflozin 10 mg daily or matching placebo over a median of two years follow-up. Serum uric acid was measured at randomisation then 2 and 18 months of follow-up and the effects of empagliflozin were analysed using a pre-specified mixed model repeated measures approach. …”

The influence of nicotinic acid adenine dinucleotide phosphate (NAADP) signalling and the significance of the organization of lysosomes in cardiac myocytes by Aston, D

“…</p> <p>One regulatory factor that has earned much attention in recent years is Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and its probable receptor, Two-Pore Channel-2 (TPC2), which is found on the surface of lysosomes. …”

The impact of social isolation on delayed hospital discharges of older hip fracture patients and associated costs by Landeiro, F, Leal, J, Gray, A

“…Costs of delayed discharges were estimated using unit costs from national databases.Mean age at admission was 85.5 years and mean length of stay was 13.1 days per patient. …”

Ethnicity and anthropometric deficits in children: A cross-sectional analysis of national survey data from 18 countries in sub-Saharan Africa by Tusting, LS, Mishra, S, Gibson, HS, Lindsay, SW, Weiss, DJ, Flaxman, S, Bhatt, S

“…Data were extracted from 37 georeferenced Demographic and Health Surveys carried out during 2006–2019 across SSA that recorded anthropometric data for children aged <5 years. In a cross-sectional analysis, the odds of stunting (low height-for-age), wasting (low weight-for-height) and underweight (low weight-for-age) were modelled in relation to ethnic group using a generalised linear hierarchical mixed-effects model, controlling for survey design and environmental, socioeconomic and clinical variables. …”

The 2-dimensional to 3-dimensional growth transition in Physcomitrium patens by Weeks, Z

“…Plants colonised the land around 470 million years ago. This was facilitated by the acquisition of apical cells capable of dividing in three dimensions, which allowed the development of complex 3-dimensional (3D) morphologies. …”

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data by Murrin, O, Mounier, N, Voller, B, Tata, L, Gallego-Moll, C, Roso-Llorach, A, Carrasco-Ribelles, LA, Fox, C, Allan, LM, Woodward, RM, Liang, X, Valderas, JM, Khalid, S, Dudbridge, F, Lamb, SE, Mancini, M, Farmer, L, Boddy, K, Bowden, J, Melzer, D, Frayling, TM, Masoli, JAH, Pilling, LC, Violán, C, Delgado, J

“…</p> <p><strong>Methods: </strong>We defined chronic, common, and heritable conditions in individuals aged ≥65 years, using two large primary-care databases [CPRD (UK) N = 2,425,014 and SIDIAP (Spain) N = 1,053,640], and estimated heritability using the same definitions in UK Biobank (N = 451,197). …”

Self-harm-related mental imagery: a content analysis study of imagery reported by young people referred to mental health services by Susi, K, Stewart, A, Knowles Bevis, R, Hawton, K

“…<p><strong>Results: </p></strong>55 young people aged 14-24 years old completed the study. Participants were mostly female (85.5%) and White (87.3%). …”

Climate and biodiversity in the Andean Dry Puna by Bennett Manzano, M

“…There was no significant temporal trend in productivity in the study area since 1980 and NDVI variability was chiefly driven by ENSO conditions (lower during El Niño years, with dry and hot summers). At a finer scale, vegetation types responded to low rainfall in different ways; tussock grasslands were the most affected by low rainfall; wetlands and scrublands the most resilient. …”

Breastfeeding support during the Covid-19 pandemic in England: analysis of a national survey by Quigley, M, Harrison, S, Levene, I, Buchanan, P, McLeish, J, Alderdice, F

“…<p><strong>Conclusions</p></strong> Breastfeeding support has declined in recent years, and did not meet the needs of many women during the pandemic. …”

Indicators of global climate change 2022: annual update of large-scale indicators of the state of the climate system and human influence by Forster, PM, Smith, CJ, Walsh, T, Lamb, WF, Lamboll, R, Hauser, M, Ribes, A, Rosen, D, Gillett, N, Palmer, MD, Rogelj, J, von Schuckmann, K, Seneviratne, SI, Trewin, B, Zhang, X, Allen, M, Andrew, R, Birt, A, Borger, A, Boyer, T, Broersma, JA, Cheng, L, Dentener, F, Friedlingstein, P, Gutiérrez, JM, Gütschow, J, Hall, B, Ishii, M, Jenkins, S, Lan, X, Lee, J-Y, Morice, C, Kadow, C, Kennedy, J, Killick, R, Minx, JC, Naik, V, Peters, GP, Pirani, A, Pongratz, J, Schleussner, C-F, Szopa, S, Thorne, P, Rohde, R, Rojas Corradi, M, Schumacher, D, Vose, R, Zickfeld, K, Masson-Delmotte, V, Zhai, P

“…However, successive IPCC reports are published at intervals of 5&ndash;10 years, creating potential for an information gap between report cycles.…”

Deep learning methods for genome-based prediction of drug resistance in Mycobacterium tuberculosis by Wang, C

“…<p>Tuberculosis is a highly lethal infectious disease, causing approximately 1.5 million deaths annually. Recent years have seen a concerning rise in drug-resistant tuberculosis cases, calling for the development of new approaches for drug susceptibility testing. …”

Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…Combination therapies that exploit different ways to treat cancer cells, while minimising adverse side-effects, have gained increased traction in recent years. In particular, hyperthermia (HT) has emerged as a promising candidate for enhancing tumour responses to radiotherapy (RT), a well-established cancer treatment used to treat more than 50% of cancer patients. …”

Implementing strategies to improve uptake of patient-reported outcome measures (PROMs) in gender-affirming care: a mixed-methods implementation study by Kamran, R, Jackman, L, Goodwin, C, Laws, A, Stepney, M, Harrison, C, Jain, A, Rodrigues, J

“…</p> <p><strong>Results</strong> A total of 28 participants were included in this study with a mean (SD) age of 39 (17) years. In general, participants rated education material for PROMs as the most important for PROM implementation, and accessibility options for PROMs as the second most important. …”

Self-reported pain and osteoarthritis of the hip and spine in retired elite rowers by Baynham-Williams, M

“…</p> <p><b>Results:</b> 92 participants were included in the analysis (age: 49.7 ± 17.8 years; BMI: 24.8 ± 2.7 kg/m2). The prevalence of self-reported pain at the hip joint, and across the thoracic spine and lower back was 14.1%, 9.8% and 29.4%, respectively. …”

Water quality in the Dhaka river system, Bangladesh, January 2017 to July 2021 by Hossain, MA, Shawal, S

“…<p>This dataset comprises periodical analysis of various water quality parameters including organics, inorganics and microbial concentrations from 58 sampling points over five years (2017-2021) in rivers and canals in the Greater Dhaka watershed, Bangladesh (Turag, Tongi Khal, Balu, Buriganga, Bangshi-Savar, Shitalakhya, Dhaleshwari, Kaliganga Pagar Canal, Bashundhara Canal, Begunbari Canal). …”

Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis by Aung, HKK, Swe, LL, Saito, M, Lesseps, S, Janurian, N, Tun, WPP, Maung Maung, B, Than, A, Watthanaworawit, W, Kaewphanderm, N, Gornsawun, G, Pyae Phyo, A, Nosten, F

“…The median (interquartile range) age was 48 (33.5-57.0) and 27 (23-33) years in the TB and in the non-TB COVID-19 patients, respectively. …”

Virulence gene profiles and antimicrobial susceptibility of Salmonella Brancaster from chicken by Khoo, Evie, Roslee, Roseliza, Zakaria, Zunita, Ahmad, Nur Indah

“…Surveillance data from Malaysian poultry farms indicated an increase in its presence over the years. Objective: This study aims to investigate the virulence determinants and antimicrobial resistance in S. …”
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Studies of seed-borne fungi of tropical pasture legume species by Nik, WZ, Parbery, DG

“…P. sorghina was also found in embryo and cotyledonary tissue and survived in infected seed for at least 5 years. One storage fungus, Aspergillus ruber, was a seed (embryo) pathogen. …”

Absolute deviance method for symmetrical uniform designs by Lau, Grace Chui Ting

“…Moreover, there is no development of new construction methods in the recent years. Therefore, two of the existing construction methods of uniform design; the optimization method and the cutting method are analyzed and modified to a better approach in terms of computation time and uniformity. …”
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