All the Islands the Island: the crafting of Cortázar's 'La isla a mediodía' by Moran, DP

“…This essay aims to achieve a better understanding of how Julio Cortázar came to write one of his most iconic stories, ‘La isla a mediodía’, as and when he did by identifying the various literary sources on which he may have drawn, including D. H. Lawrence’s story ‘The Man Who Loved Islands’, various works by Aldous Huxley, and, above all, William Golding’s novel Pincher Martin. …”

Perceptions of females participating in a perceived ‘masculine sport’ : dragon boat by Vijaikumar Rangabashayam

“…Therefore, the Athletic Identity of an individual is a relevant factor in the perception of female athletes participating in Dragon Boat. These findings lead to the discussion of potential barriers posed by the perceptions on females participating in the sport of Dragon Boat. …”
Get full text

Studies on the antioxidant mechanisms of betacyanins from improved fermented red dragon fruit (Hylocereus polyrhizus) drink in HepG2 cells by Lim, Teck Wei, Lim, Renee Lay Hong, Pui, Liew Phing, Tan, Chin Ping, Ho, Chun Wai

“…Red dragon fruit (RDF, Hylocereus polyrhizus) is high in betacyanins content but is understudied for its antioxidant mechanisms in liver cells. …”
Get full text

‘When I open it, I have to drink it all’: push and pull factors shaping domestic alcohol consumption during the COVID-19 pandemic UK Spring 2020 lockdown by Conroy, Dom, Nicholls, Emily

Get full text

Development of Attention-based Prediction Models for All-cause Mortality, Home Care Need, and Nursing Home Admission in Ageing Adults in Spain Using Longitudinal Electronic Health... by Carrasco-Ribelles, LA, Cabrera-Bean, M, Khalid, S, Roso-Llorach, A, Violán, C

“…The models included attention mechanisms to increase their transparency. EHRs were drawn from SIDIAP (primary care, Catalonia (Spain)) from 2010-2019. …”

Near-infrared light for phototherapy : photothermal induced drug release and tumor ablation by Li, Menghuan

“…The lessons learnt from the dual responsive core/shell drug nanocarrier proved substantial, which offered useful insights for the shaping of a new NIR responsive drug delivery system. …”
Get full text

Drag reduction in fish-like locomotion by Barrett, D.S., Triantafyllou, M.S., Yue, D.K.P., Grosenbaugh, M.A., Wolfgang, M.J.

Get full text

Expediting treatments in the 21st century: orphan drugs and accelerated approvals by Domike, Reuben, Raju, G. K., Sullivan, Jamie, Kennedy, Annie

“…In 1983, the United States Congress passed the Orphan Drug Act to provide financial incentives for development of drugs for rare diseases. …”
Get full text

Triggered drug release and enhanced drug transport from ultrasound-responsive nanoparticles by Kwan, JJ, Coussios, CC

“…Conventional systemic drug therapy across all drug classes does not adequately provide safe and efficacious treatment for a broad range of fatal diseases. …”

Feasibility study of using 3D printed polymer sleeves for local deburring of test coupons using Drag finishing process by Muhammad Asyaari Juraimi

“…On the other hand, Drag Finishing requires the whole part to be inserted into the machine where all of the surfaces being exposed and burred. …”
Get full text

Toxicity, permeability and drug-metabolizing enzyme activities of curcumin analogues by Yakubu, Ndatsu

“…Similarly, toxicity, permeability effects and drug-metabolizing enzyme activities of curcumin (reference compound) and 3-(2-fluoro-benzylidene)-5-(2-fluorocyclohexylmethylene)-piperidin-4-one (EF-24) (positive control) in differentiated Caco2 and adult male zebrafish were conducted for comparison. …”
Get full text

Development of DragGAN application for photographers by Takesawa, Saori

“…In response to these challenges, the development of Simple DragGAN—an application aimed at simplifying DragGAN's functionalities—has been undertaken. …”
Get full text

Computational screening of FDA-approved hepatitis c drugs for inhibition of VEGFR2 in liver cancer by Roney, Miah, Issahaku, Abdul Rashid, Tufail, Nasir, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Towards a comprehensive rationalisation of the search for new anti-LC drugs among approved ones, we employed an in-silico approach to accelerate the selection of the most efficacious LC drugs. …”
Get full text

Targeting the cytochrome oxidases for drug development in mycobacteria by Lee, Bei Shi, Sviriaeva, Ekaterina, Pethe, Kevin

Get full text

Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites by Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani

Get full text

Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience by Buccheri, S, James, S, Mafham, M, Landray, M, Melvin, T, Oldgren, J, Bulbulia, R, Bowman, L, Hoogervorst, LA, de Mheen, PJM, Juni, P, McCulloch, P, Fraser, AG

“…They are considered essential to establish definitive evidence of efficacy and safety for new drugs, and whenever possible they should also be the preferred method for investigating new high-risk medical devices. …”

From the body to the brain: Studying drug delivery and physiological interactions using MRI by Dawson, Miranda

“…With molecular imaging approaches, we show the insula shapes drug-dependent brain phenotypes and physiological responses during substance exposure and withdrawal. …”
Get full text

Hollow microcapsules as periocular drug depot for sustained release of anti-VEGF protein by Radhakrishnan, Krishna, Vincent, Anita, Joseph, Rini Rachel, Moreno, Miguel, Dickescheid, Andreas, Agrawal, Rupesh, Venkatraman, Subbu S.

“…In an attempt to develop less invasive alternatives, we propose the use of a controlled release system consisting of anti-VEGF loaded hollow microcapsules that can be administered periocularly to form drug eluting depots on the episcleral surface. The microcapsules with either positive or negative surface charge were prepared by a layer by layer approach and showed pH responsive permeability switching. …”
Get full text

Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India by Kaza, P, Xavier, BB, Mahindroo, J, Singh, N, Baker, S, Nguyen, TNT, Mavuduru, RS, Mohan, B, Taneja, N

“…Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. …”

Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…The studies described in this thesis were undertaken to evaluate the application of paper spray mass spectrometry for direct analysis of small molecule drugs and biomarker in dried matrix spot samples. …”
Get full text