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1
Boronic acid and nitrofuranyl derivatives as potential therapeutics
Published 2021“…Whereas in the recent past drug development has often focussed on molecular structures with limited pharmacokinetic parameters e.g. …”
Thesis -
2
Genomic profiling of mycobacterium tuberculosis strains, Myanmar
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Journal Article -
3
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases
Published 2017“…The World Health Organization (WHO) has reported that globally 235 million people suffer from chronic and other inflammatory diseases. The short half-lives of nonsteroidal anti-inflammatory drugs (NSAIDs) and their notoriety in causing gastrointestinal discomforts, warrants these drugs to be released in a controlled and sustained manner. …”
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Journal Article -
4
Use of peptide asparginyl ligases (PALs) in generating alternative non-Ig protein-drug conjugates for cancer therapy
Published 2023“…Past research on antibody–drug conjugates (ADCs) focused on protein site-specific modification as chemical conjugation lacks site-selectivity. …”
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Final Year Project (FYP) -
5
Studies towards the synthesis of bioactive natural products and development of new synthetic methods
Published 2017“…It has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. …”
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Thesis -
6
Preparation for and performance of a Pseudomonas aeruginosa biofilm experiment on board the International Space Station
Published 2024“…The samples were integrated into the spaceflight hardware, BioServe's Fluid Processing Apparatus (FPA), packed in sets of eight in Group Activation Packs (GAP). Half of these samples were activated and terminated on orbit by NASA astronauts Jessica Meir and Christina Koch, while the remaining half were processed equivalently on Earth. …”
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Article -
7
Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer
Published 2024“…To minimize the dosage of both drugs, we have developed a drug delivery strategy that prepared metformin as a nanoderivative, denoted as MA-dots. …”
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Journal Article -
8
The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis
Published 2024“…<p><strong>Background: </strong>Effective antiviral drugs accelerate viral clearance in acute COVID-19 infections; the relationship between accelerating viral clearance and reducing severe clinical outcomes is unclear.…”
Journal article -
9
Synergistic effect of 5-fluorouracil and the small molecule Wnt/β-catenin inhibitor iCRT3 on Caco-2 colorectal cancer cells in vitro
Published 2025“…Subsequently, the drugs were combined in different ways, and drug combination index (DCI) calculations were performed to evaluate their interaction. iCRT3 was found to be 2.45-fold more potent than 5-FU (p = 0.1982). …”
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Article -
10
Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses)
Published 2017“…While there are few clinically approved anti-IAV drugs for therapeutic and prophylactic use, these drugs have also been challenged by the emergence of drug resistance, toxicity, adverse effects and low efficacy. …”
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Thesis-Doctor of Philosophy -
11
In vitro anti-proliferative mechanism of combination therapy with tannic acid and cisplatin against human osteosarcoma cell line U2OS
Published 2024“…The half-maximal inhibitory concentration (IC50) values of TA and its combination with cisplatin against U2OS cells were determined using MTT assay. …”
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Thesis -
12
Structural and mechanistic studies of herpes virus proteins
Published 2015“…The structure reveals the C-terminal half of ICP27 to be a bundle of α-helices along with a unique zinc-fingerlike motif. …”
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Thesis -
13
Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures
Published 2024“…The second half of this thesis focuses on the introduction of degradable bonds into the polymer backbone of vinylic thermosets via radical ring-opening polymerization (rROP). …”
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Thesis -
14
A synthetic biology platform for malaria parasites based on orthogonal transcriptional control
Published 2024“…Malaria is responsible for half a million deaths each year in some of the poorest communities around the world. …”
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Thesis -
15
Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats
Published 1999“…The bioavailability (f) of the drug in goats (0.84 ± 0.11) was not significantly higher than that in sheep (0.73 ± 0.08). …”
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Article -
16
Design and Synthesis of Stimuli-Responsive Polymers with Programmable Cleavability
Published 2024“…The third chapter investigates a synergistic approach to treating pancreatic ductal adenocarcinoma (PDAC) with drug-loaded BBPs by leveraging multiple facets of structural modularity, including linker and drug identities and concentration ratios. …”
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Thesis -
17
Development of image-based method for the quantitative assessment of cartilage damage from CT as a biomarker in osteoarthritis
Published 2024“…<p>Preclinical studies, like those for drug development, require quantitative methods to assess osteoarthritis (OA). …”
Thesis -
18
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19
Synthesis and characterization of silver nanoprism-based nanostructures
Published 2013“…Noble metal nanostructures, ranging from a few atom clusters to micrometer-long nanocrystal, have attracted tremendous attention for more than half a century. They have shown the unique physical and chemical properties, which make them promising candidates in a wide range of applications, such as catalysis, electronics, optics, sensing, bioimaging and gene regulation. …”
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Thesis -
20
Effectiveness of cognitive behavior therapy and Reiki therapy on adolescents with depressive disorders inTehran, Iran
Published 2014“…The CBT program was arranged in two sessions of one and a half hours per week. The planning totaled eighteens hours in twelve sessions over six weeks of the treatment period. …”
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Thesis