The treatment of malaria in pregnancy by Nosten, F, McGready, R

“…Studies are urgently needed to define the best therapeutic options and to develop new treatments, especially in Africa where drug resistance already compromises all strategies of control.…”

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil by Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär

“…The screen selected accurately for all the tested known drugs acting on TS. We also identified TS inhibitors with novel chemistry and marketed drugs that were not previously known to target TS, including the DNA methyltransferase inhibitor decitabine. …”
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Resistant hypertension and mortality: an observational cohort study by de la Sierra, A, Ruilope, LM, Staplin, N, Gorostidi, M, Vinyoles, E, Segura, J, Armario, P, Oliveras, A, Williams, B

“…<p><strong>Methods</strong></p> We selected 8146 patients with controlled hypertension (office BP &lt;140/90 mm Hg while being treated with ≤3 antihypertensive drugs) and 8577 with resistant hypertension (BP ≥140 or ≥90 mm Hg while being treated with ≥3 drugs). …”

Dopamine Nation : Finding Balance in the Age of Indulgence / by Lembke, Anna, Dr., author 655980, Penguin Publishing Group (Online service) 655981

“…Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. …”
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Protein delivery options: how well have we succeeded? by Ng, Xu Wen, Subbu, Venkatraman

“…Of the ten top-selling drugs in 2013, the first three (Humira®, Enbrel®, Remicade®) were all monoclonal antibodies for treating autoimmune diseases; together these three accounted for approximately $28 billion in sales. …”
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Detection of single-nucleotide polymorphisms in Plasmodium falciparum by PCR primer extension and lateral flow immunoassay by Moers, APHA, Hallett, R, Burrow, R, Schallig, HDFH, Sutherland, CJ, van Amerongen, A

“…The resistance of Plasmodium falciparum to some antimalarial drugs is linked to single-nucleotide polymorphisms (SNPs). …”

Studies towards the synthesis of bioactive natural products and development of new synthetic methods by Khanizeman, Rabi’ah Nisha

“…It has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. …”
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The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…<p>Colorectal cancer (CRC) currently represents one of the most commonly diagnosed tumors, accounting for 10% of all cancer diagnoses and cancer-related deaths. …”

建立知识经济时代的竞争优势 = Building the competitive advantage in the knowledge economy : an analysis of the added-value of the intellectual capital of Xian-Janssen from the knowledge manageme... by 李一敏 Li, Yimin

“…"Xian-Janssen Pharmaceutical Ltd", as the No.1 leading pharmaceutical JV in China, is a successful model among all.…”
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Synthesis of chiral sulfinate esters by asymmetric condensation by Zhang, Xin, Ang, Esther Cai Xia, Yang, Ziqi, Kee, Choon Wee, Tan, Choon-Hong

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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…Hence, development of a broad range anti-IAV drug that could target all of the IAV strains irrespective of their source is critically important. …”
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Factors affecting trans-scleral transport of poly (butadiene-b-ethylene oxide) polymersomes by Anita, Vincent

“…In this light, this research work examines the suitability of polymersomes for ocular drug delivery via periocular route of drug administration. …”
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Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum by Hu, Guang An

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Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine learning approaches by Carter, J, Walker, T, Walker, A, Whitfield, M, Morlock, G, Lynch, C, Adlard, D, Peto, T, Posey, J, Crook, D, Fowler, P

“…<p><strong>Methods</p></strong> We curated a dataset of 664 non-redundant, missense amino acid mutations in PncA with associated high-confidence phenotypes from published studies and then trained three different machine-learning models to predict pyrazinamide resistance. All models had access to a range of protein structural-, chemical- and sequence-based features. …”

Migration of magnetic microparticles through a liquid–liquid interface under an external magnetic field by Mondal, S, Abbasi, N, Tsai, SSH, Griffiths, IM

“…Liquid–liquid interfaces play a pivotal role in various microfluidic processes involving microparticles, including coating, dissolution, controlled release of polyelectrolytes or drugs, and self-assembly processes. In all of these cases, non-invasive techniques to manipulate the microparticle transport are essential. …”

Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

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Integrate Traditional Chinese Medicine (TCM) into cognitive behavioural therapy to treat postpartum depression in Chinese culture contexts. by Han, Shuyu.

“…As in Chinese cultures, it is believed that any kind of drug has certain degree of side effects. In the end, all different kinds of factors have lead to the fact that most women suffering from postpartum disorders or depression left unwell treated. …”
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Cheaper Than A Funeral: Considering Ibogaine’s Psychedelic Journey and Therapeutic Potential by Daly, Noah

“…This thesis examines the cases of three patients–all United States military veterans–undergoing ibogaine therapy, examining how the biological impacts of ibogaine, as well as their psychedelic experiences, may have saved their lives.…”
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Nickel-catalyzed enantioselective reductive arylation and heteroarylation of aldimines via an elementary 1,4-addition by Zhang, Luoqiang, Wang, Xiuhua, Pu, Maoping, Chen, Caiyou, Yang, Peng, Wu, Yun-Dong, Chi, Robin Yonggui, Zhou, Steve Jianrong

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Mechanism of damnacanthal induced apoptosis in CEM-SS cell line by Gopalsamy, Banulata, Saiful Yazan, Latifah, Abdul Hamid, Hisyam

“…Due to the harsh effects of currently used cancer drugs, damnacanthal, an anthraquinone obtained from the roots of Morinda elliptica is tested as a potential anticancer agent. …”
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