Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…The studies described in this thesis were undertaken to evaluate the application of paper spray mass spectrometry for direct analysis of small molecule drugs and biomarker in dried matrix spot samples. …”
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Amplifying signals in the tumor microenvironment for drug development and diagnostics by Martin Alonso, Maria Carmen

“…Leveraging advancements in high throughput screening and in deep learning, we contribute important tools for the effective design of conditional drugs that require the cleavage of a protease substrate to unleash drug cytotoxicity. …”
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Nanosized silica particles for achiral drug separation by Tan, Timothy Thatt Yang.

“…The main objectives of the project are: (1) to synthesize and functionalize silica nanoparticles and (2) apply the nanosilica for achiral drug separation. A modified Stober method is used to synthesize the silica nanoparticle. …”
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Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy by Leylek, Ozen, Honeywell, Megan E., Lee, Michael J., Hemann, Michael T., Ozcan, Gulnihal

“…However, realizing the full potential of this approach requires a clear comprehension of the genetic dependencies underlying drug synergy. …”
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18F-labelling of new chemotypes for drug discovery by Khotavivattana, T

“…<b>Chapter 2</b> describes a novel silver-mediated ¹⁸F-labelling of Ar-SCF3, Ar OCF3 and Ar-OCF2H, including [¹⁸F]Riluzole, the ¹⁸F labelled version of a drug for treatment of amyotrophic lateral sclerosis (ALS). …”

Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases by Baek, Jong-Suep, Yeo, Eng Wan, Lee, Yin Hao, Tan, Nguan Soon, Loo, Say Chye Joachim

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Mitochondrial dysfunction in Down Syndrome: from pathology to therapy by Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa

“…Various therapeutic approaches for modulating energy deficits in DS, effects and molecular mechanism of gene therapy and drugs that exert protective effects through modulation of mitochondrial function and attenuation of oxidative stress in DS cells were discussed. …”
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SP.236 / ES.SP236 Exploring Pharmacology, Spring 2009 by Gusman, Mariya, Fallows, Zak

“…Planned topics include over-the-counter drugs and "dietary supplements," drugs of abuse, treatments for neurological disorders, psychiatric medications, and many more. …”
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Effect of metabolite and temperature on artificial human sweat characteristics over a very wide frequency range (400 MHz–10.4 GHz) for wireless hydration diagnostic sensors by Lubangakene, Innocent, Virdee, Bal Singh, Jayanthi, Renu, Ganguly, Priyanka

“…As a result, analysis of electrolytes in this biofluid is gaining traction in the development of non-invasive sweat diagnostics to determine level of dehydration, cystic fibrosis and illicit drugs. This paper presents a wireless measurement modality of permittivity properties of sweat of different metabolite concentration levels exemplifying the full spectrum of human sweat. …”
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Combined ultrasound and photoacoustic imaging of blood clot during microbubble-assisted sonothrombolysis by Das, Dhiman, Pramanik, Manojit

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The role of tumour necrosis factor alpha stimulated gene-6 on bone by Afrough, S

“…Depending on the severity of the disease, most patients are often treated with calcium/vitamin D and anti-resorptive drugs such as bisphosphonates or calcitonin. However, there are few options for bone formation using anabolic agents- such as Teriparatide (PTH_1-34), which have limited success, creating an unmet need for novel anabolic interventions.…”

Duration of carbapenemase-producing enterobacteriaceae carriage in hospital patients by Mo, Yin, Hernandez-Koutoucheva, Anastasia, Musicha, Patrick, Bertrand, Denis, Lye, David C., Ng, Oon Tek, Fenlon, Shannon N., Chen, Swaine L., Ling, Moi Lin, Tang, Wen Ying, Barkham, Timothy, Nagarajan, Niranjan, Cooper, Ben S., Marimuthu, Kalisvar

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Ion doping behavior of stöber silica-nanosynthesis and application by Song, Xiaohui

“…Besides, we can dope positive charged organic molecules inside silica nanoparticle, such as dyes, drugs, and so on. The above synthesis control is important to silica application in biosensors, drug delivery, catalysts, and battery. …”
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Association of current Schistosoma mansoni, Schistosoma japonicum, and Schistosoma mekongi infection status and intensity with periportal fibrosis: a systematic review and meta-ana... by Ewuzie, A, Wilburn, L, Thakrar, DB, Cheng, H, Reitzug, F, Roberts, N, Malouf, R, Chami, GF

“…In sub-Saharan Africa, before the widespread introduction of mass drug administration in 2003 there was a significant association between current infection status and periportal fibrosis (OR 5&middot;38, 95% CI 2&middot;03&ndash;14&middot;25) but this association was no longer present after 2003 (1&middot;19, 0&middot;82&ndash;1&middot;74). …”

Investigation of Synthetic Proteins Produced via Automated Fast-Flow Peptide Synthesis by Cowfer, Amanda Elizabeth

“…In the research arena, luciferases have had broad applications for decades, including detection of environmental contaminants, diagnosis of pathogens, high-throughput screening for drug discovery, understanding protein-protein interactions, and more. …”
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Optimising expression and purification of Dengue soluble E protein by Poh, Nina Yong Xin

“…Successful modification and vector expression in pcDNA3.1 enhance solubility, enabling drug development and testing. This project sets a baseline for future functional and mechanistic understanding. …”
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Improving access to pulmonary rehabilitation for patients with COPD treated for substance misuse in the London Borough of Islington by Narasimhan, Divya, Simpson, Jane, Stewart, Duncan

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Barriers and leverage points for seeing alcohol differently in integrated care systems in England: a senior stakeholder interview study by Madden, Mary, Stewart, Duncan, McCambridge, Jim

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Design, simulation, and testing of a low cost laser micromachining system for flexible and rapid tissue-on-chip fabrication. by Nin, Jorge A.

“…This approach has the potential to overcome the limitations of traditional methods, enabling the next generation of sophisticated, physiologically relevant in vitro models for biomedical research and drug development. The successful development and validation of the FEM model, coupled with practical demonstrations, provide a solid foundation for further advancements in laser-based fabrication of tissue-on-chip devices, potentially accelerating drug discovery processes and enabling more accessible production of personalized medicine platforms.…”
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Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy by Goh, Wei Jiang, Lee, Choon Keong, Zou, Shui, Woon, Esther, Czarny, Bertrand, Pastorin, Giorgia

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