Investigating the role of astrocytes in Parkinson's disease pathogenesis in GBA- N370S iPSC-derived neural cultures by Ibarra Aizpurua, N

“…However, the research available indicates that other cells found in the midbrain, such as astrocytes, are also involved in the disease pathogenesis, although their role has not been fully elucidated yet. Moreover, it is still to be determined whether the neuroinflammation found in PD patients has a causative effect in disease onset or is in turn a consequence of neurodegeneration. …”

Understanding sudden larch death – from epidemiology to host resistance by Dun, H

“…By 2019 at least 20,700 hectares of larch had been killed due to P. ramorum infection or felled in efforts to contain the pathogen. …”

Using machine learning to discover candidate localised transcripts from microscopy and genome-wide bioinformatics data by Kiourlappou, M

“…Proper mRNA localisation is vital for the correct functioning of the entirety of a glial cell and dysregulation of mRNA localisation in glial cells has been implicated in neurodegenerative and neurological diseases and some types of cancer. …”

Genetic analysis of normal human phenotypes within the people of the British Isles by Meena, D

“…<p>Genome-wide association studies have been of fundamental use in identifying common risk alleles with modest effects underlying multifactorial diseases such as diabetes, cancer, Crohn's disease as well as in polygenic traits, such as pigmentation, involving multiple genes. …”

Investigating the health and care needs of pregnant women with multiple long-term conditions by D'Arcy, R

“…MLTC was observed to be a common health concern among pregnant women, and is likely to become increasingly prevalent in the future. MLTC has been shown to be an important component of inequitable maternal and perinatal outcomes, even up to one year after birth. …”

Landless in God’s own country: development and perpetual struggles in Kerala by Ramapurath Chemmencheri, S

“…Illustrating seven different sectors from which livelihood expulsions are underway in the lives of landless Adivasis in Kerala, the thesis argues that their position in the local growth trajectory can be understood as an “in-between” one, wherein their wage labour is becoming less and less relevant to the local growth path, although they remain embedded in capitalist relations. Meanwhile, they have been dissuaded from turning into labourers in constant migration by virtue of welfare provisions and political mobilisation. …”

Chronic neuropsychiatric sequelae of SARS-CoV-2: protocol and methods from the Alzheimer's Association Global Consortium by de Erausquin, GA, Snyder, H, Brugha, TS, Newton, C

“…At least twice as many have been infected but remained asymptomatic or minimally symptomatic. …”

‘Des nouvelles de mon infortunée sœur’: Marie-Antoinette dans les lettres de l’archiduchesse Marie-Christine à l’empereur François by Seth, C

“…Not only were the Austrian Netherlands (of which the duke and duchess of Saxony-Teschen were governers) at boiling point, war had also been declared between Marie-Antoinette’s homeland and the country where she hoped her son the dauphin would one day reign. …”

Distribution and risk factors of canine heart diseases and survey for owners treatment intention by Noordin, Norhidayah

“…Early detection and treatment of heart disease had been shown to improve quality of life and prolong lifespan. …”
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Green logistics practices in Malaysian food-based manufacturing industry by Hussin, Hilda

“…Logistics has been regarded as a key determinant to business performance over the past 50 years. …”
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Effect of detergent, herbs and spices on the growth of Vibrio parahaemolyticus biofilm in seafood by Nillian, Elexson

“…The prevalence of 9.14% (36/394) of positive toxR genes, 63.8% of positive isolates contained virulent genes of V. parahaemolyticus tdh+, 22.2% of V. parahaemolyticus trh+, and 5.56% (2/36) of positive isolates in both V. parahaemolyticus tdh+ and trh+ had been detected. The thirty six (n=36) isolates were further tested with antibiotic susceptibility test and they werefound to be resistant to at least seven out of eighteen antibiotics. …”
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Computational stylometric model for oath and oath-like expressions in Quranic text by Alqurneh, Ahmad

“…While the Quranic oath has been widely studied from theoretical base in Islamic Studies, it has not being treated from computational perspective. …”
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Color and flavor development of roasted jackfruit (Artocarpus hetrophyllus L.) seeds by Azeez, Shakirah Omotoke

“…Most studies on jackfruit seed (JFS) have been focused on the chemical, functional, and nutritive values of both raw and processed (cooked) jackfruit seed flour. …”
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Layer-by-Layer Nanoparticles for Cytokine Delivery by Pires, Ivan S.

“…In the past decade, cancer immunotherapy has been a promising therapeutic strategy for cancer treatment. …”
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Novel material composites for dielectric elastomer actuators by Ankit

“…Robots have been around us for quite some time now. Robots are machines capable of performing tasks on their own with high accuracy and precision and minimal supervision to reduce human effort. …”
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Visualization of engine design, simulation and optimization by Wang, Yan Chao

“…Most of our work are implemented in JavaScript and the source code of the proposed PolarViz and the orthogonal Voronoi treemap have been uploaded into the GitHub. The thesis ends with the conclusions of our works and a discussion of future work.…”
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Phase measurements based indoor visible light positioning systems by Zhang, Sheng

“…Applications of LEDs in indoor communications have been gradually investigated in the last two decades. …”
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Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…Objective:b-cell dedifferentiation has been revealed as a pathological mechanism underlying pancreatic dysfunction in diabetes. …”
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Rotor angle stability-constrained dispatch and control of large-scale wind penetrated power system by Yuan, Heling

“…In current research, robust optimization has been demonstrated as an effective approach to deal with uncertainties and ensure the robustness. …”
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Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion by Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.

“…Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously been explored. Here, we generated mice with β-cell-selective, adult-restricted deletion knock-out (dKO) of the mitofusin genes Mfn1 and Mfn2 (βMfn1/2 dKO). βMfn1/2-dKO mice displayed elevated fed and fasted glycemia and a more than fivefold decrease in plasma insulin. …”
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