Rapid and punctuated Late Holocene recession of Siling Co, central Tibet by Shi, Xuhua, Kirby, Eric, Furlong, Kevin P., Meng, Kai, Robinson, Ruth, Lu, Haijian, Wang, Erchie

“…Lake expansion and contraction in response to changing water balance are likewise inferred from sedimentologic, isotopic and paleobiologic proxies, but relatively few direct records of changes in lake volume from preserved shorelines exist. Here we utilize relict shoreline deposits and associated alluvial fan features around Siling Co, the largest lake in central Tibet, to reconstruct centennial-to-millennial-scale variations in lake area and volume over the Holocene. …”
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β-Ginkgotides: Hyperdisulfide-constrained peptides from Ginkgo biloba by Wong, Ka Ho, Tan, Wei Liang, Xiao, Tianshu, Tam, James P.

“…Thus far, these peptides have been reported from animals only but their occurrence in plants are rare. Here, we report the discovery, synthesis and characterization of a hyperdisulfide-constrained peptides family of approximately 2 kDa, β-ginkgotides (β-gB1 and β-gB2) from Ginkgo biloba. …”
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Ambipolar ferromagnetism by electrostatic doping of a manganite by Zheng, L. M., Lü, W. M., Li, C. J., Paudel, T. R., Liu, Z. Q., Huang, Z., Zeng, S. W., Han, Kun, Qiu, X. P., Li, M. S., Yang, Shize, Wang, Xiao Renshaw, Chen, Z. H, Yang, B., Chisholm, Matthew F., Martin, L. W., Pennycook, S. J., Tsymbal, E. Y., Coey, J. M. D., Cao, W. W.

“…However, an ambipolar oxide that is able to exhibit both electron-doped and hole-doped ferromagnetism in the same material has proved elusive. Here we report ambipolar ferromagnetism in LaMnO3, with electron–hole asymmetry of the ferromagnetic order. …”
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N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5 by Zou, Shui, Toh, Joel D. W., Wong, Kendra H. Q., Gao, Yong-Gui, Hong, Wanjin, Woon, Esther C. Y.

“…The m6A mark is dynamically reversed by human demethylases FTO and ALKBH5, however the mechanism by which these enzymes selectively recognise their target transcripts remains unclear. Here, we report combined biophysical and biochemical studies on the specificity determinants of m6A demethylases, which led to the identification of an m6A-mediated substrate discrimination mechanism. …”
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Single plasmonic structure enhanced dual-band room temperature infrared photodetection by Tong, Jinchao, Luo, Yu, Zhang, Dawei, Zhang, Dao Hua, Tobing, Landobasa Yosef Mario

“…The capability of surface plasmons in confining electromagnetic waves into extremely small volume provides an opportunity for improving the performance for room temperature operation. Here, we report an n-InAsSb/n-GaSb heterostructure photodiode integrated with plasmonic two-dimensional subwavelength hole array (2DSHA) for room temperature two band photodetection. …”
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Three-dimensional skeleton networks of graphene wrapped polyaniline nanofibers: an excellent structure for high-performance flexible solid-state supercapacitors by Hu, Nantao, Zhang, Liling, Yang, Chao, Zhao, Jian, Yang, Zhi, Wei, Hao, Liao, Hanbin, Feng, Zhenxing, Fisher, Adrian, Zhang, Yafei, Xu, Jason Zhichuan

“…In order to utilize them in real devices, it is necessary to improve the capacitance and the structure stability of PANI. Here we report a hierarchical three-dimensional structure, in which all of PANI nanofibers (NFs) are tightly wrapped inside reduced graphene oxide (rGO) nanosheet skeletons, for high-performance flexible SCs. …”
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Health and disease phenotyping in old age using a cluster network analysis by Valenzuela, Jesus Felix, Monterola, Christopher, Tong, Victor Joo Chuan, Ng, Tze Pin, Larbi, Anis

“…Human ageing is a complex trait that involves the synergistic action of numerous biological processes that interact to form a complex network. Here we performed a network analysis to examine the interrelationships between physiological and psychological functions, disease, disability, quality of life, lifestyle and behavioural risk factors for ageing in a cohort of 3,270 subjects aged ≥55 years. …”
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Lybatides from Lycium barbarum contain an unusual cystine-stapled helical peptide scaffold by Tan, Wei Liang, Wong, Ka Ho, Lei, Jian, Sakai, Naoki, Tan, Hong Wei, Hilgenfeld, Rolf, Tam, James P.

“…Cysteine-rich peptides (CRPs) of 2–6 kDa are generally thermally and proteolytically stable because of their multiple cross-bracing disulfide bonds. Here, we report the discovery and characterization of two novel cystine-stapled CRPs, designated lybatide 1 and 2 (lyba1 and lyba2), from the cortex of Lycium barbarum root. …”
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A novel gravity-driven nanofibrous membrane for point-of-use water disinfection: polydopamine-induced in situ silver incorporation by Wang, Jianqiang, Wu, Yichao, Yang, Zhe, Guo, Hao, Cao, Bin, Tang, Chuyang Y.

“…The strategy reported here provides an efficient and green route to synthesize point-of-use membranes. …”
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Predicting marsh vulnerability to sea-level rise using Holocene relative sea-level data by Horton, Benjamin Peter, Shennan, Ian, Bradley, Sarah L., Cahill, Niamh, Kirwan, Matthew, Kopp, Robert E., Shaw, Timothy Adam

“…Tidal marshes rank among Earth’s vulnerable ecosystems, which will retreat if future rates of relative sea-level rise (RSLR) exceed marshes’ ability to accrete vertically. Here, we assess the limits to marsh vulnerability by analyzing >780 Holocene reconstructions of tidal marsh evolution in Great Britain. …”
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Crystal phase and architecture engineering of lotus thalamus-shaped Pt-Ni anisotropic superstructures for highly efficient electrochemical hydrogen evolution by Zhang, Zhicheng, Liu, Guigao, Cui, Xiaoya, Chen, Bo, Zhu, Yihan, Gong, Yue, Saleem, Faisal, Xi, Shibo, Du, Yonghua, Borgna, Armando, Lai, Zhuangchai, Zhang, Qinghua, Li, Bing, Zong, Yun, Han, Yu, Gu, Lin, Zhang, Hua

“…The rational design and synthesis of anisotropic 3D nanostructures with specific composition, morphology, surface structure, and crystal phase is of significant importance for their diverse applications. Here, the synthesis of well‐crystalline lotus‐thalamus‐shaped Pt‐Ni anisotropic superstructures (ASs) via a facile one‐pot solvothermal method is reported. …”
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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…While HIF-1α functions in cancer progression have been increasingly recognized, the contribution of HIF-2α remains widely unclear despite accumulating reports showing its overexpression in cancer cells. Here, we report that HIF-2α up-regulates the expression of CD70, a cancer-related surface antigen that improves anchorage-independent growth in cancer cells and is associated with poor clinical prognosis, which can be induced via epigenetic modifications mediated by DNMT1. …”
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Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Davey, Curt Alexander, Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J.

“…Nonetheless, their molecular targeting and mechanism of action are poorly understood. Here we study two prototypical ruthenium-arene agents—the cytotoxic antiprimary tumour compound [(η6-p-cymene)Ru(ethylene-diamine)Cl]PF6 and the relatively non-cytotoxic antimetastasis compound [(η6-p-cymene)Ru(1,3,5-triaza-7-phosphaadamantane)Cl2]—and discover that the former targets the DNA of chromatin, while the latter preferentially forms adducts on the histone proteins. …”
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Narrow bandgap oxide nanoparticles coupled with graphene for high performance mid-infrared photodetection by Hu, Xiaonan, Zhang, Daliang, Tao, Ye, Yu, Xuechao, Li, Yangyang, Liu, Zhixiong, He, Yongmin, Md. Azimul Haque, Liu, Zheng, Wu, Tom, Wang, Qi Jie

“…However, the operation bandwidth of such photodetectors has been limited to visible and near-infrared regimes. Here we demonstrate a mid-infrared hybrid photodetector enabled by coupling graphene with a narrow bandgap semiconductor, Ti2O3 (Eg = 0.09 eV), which achieves a high responsivity of 300 A W−1 in a broadband wavelength range up to 10 µm. …”
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Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5 by Shi, Meng, Chen, Bing, Mahajan, Divyanshu, Boh, Boon Kim, Zhou, Yan, Dutta, Bamaprasad, Tie, Hieng Chiong, Sze, Siu Kwan, Wu, Geng, Lu, Lei

“…The endosome-to-Golgi or endocytic retrograde trafficking pathway is an important post-Golgi recycling route. Here we show that amino acids (AAs) can stimulate the retrograde trafficking and regulate the cell surface localization of certain Golgi membrane proteins. …”
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Signatures of a time-reversal symmetric Weyl semimetal with only four Weyl points by Belopolski, Ilya, Yu, Peng, Sanchez, Daniel S., Ishida, Yukiaki, Chang, Tay-Rong, Zhang, Songtian S., Xu, Su-Yang, Zheng, Hao, Chang, Guoqing, Bian, Guang, Jeng, Horng-Tay, Kondo, Takeshi, Lin, Hsin, Liu, Zheng, Shin, Shik, Hasan, M. Zahid

“…However, the Weyl points and Fermi arcs live entirely above the Fermi level, making them inaccessible to conventional angle-resolved photoemission spectroscopy (ARPES). Here, we use pump-probe ARPES to directly access the band structure above the Fermi level in TaIrTe4. …”
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Suitability of battery electric vehicles and opportunity charging for urban freight transport : an evaluation framework by Teoh, Tharsis Ghim Han

“…The evaluation framework proposed here deals with the gaps in existing studies, as well as proposes a novel method to evaluate electric mobility for urban freight transport in terms of operational, financial, and environmental suitability. …”
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Structures of Mycobacterium smegmatis 70S ribosomes in complex with HPF, tmRNA, and P-tRNA by Mishra, Satabdi, Ahmed, Tofayel, Tyagi, Anu, Shi, Jian, Bhushan, Shashi

“…Therefore, it is essential to have structural information on these different functional states of ribosomes to understand their mechanism of action. Here, we present single particle cryo-EM reconstructions of the Mycobacterium smegmatis 70S ribosomes in the hibernating state (with HPF), trans-translating state (with tmRNA), and the P/P state (with P-tRNA) resolved to 4.1, 12.5, and 3.4 Å, respectively. …”
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Efficient visible light modulation based on electrically tunable all dielectric metasurfaces embedded in thin-layer nematic liquid crystals by Sun, Mingyu, Xu, Xuewu, Sun, Xiao Wei, Liang, Xin’an, Valuckas, Vytautas, Zheng, Yuanjin, Paniagua-Domínguez, Ramón, Kuznetsov, Arseniy I.

“…A highly efficient tuning mechanism is immersing the metasurface in a birefringent liquid crystal (LC), whose refractive index can be electrically controlled. Here, an all-dielectric tunable metasurface is demonstrated based on this concept, operating at visible frequencies and based on TiO2 nanodisks embedded in a thin LC layer. …”
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Functional comparison of human Adenomatous Polyposis Coli (APC) and APC-like in targeting beta-catenin for degradation by Schneikert, Jean, Chandra, Shree Harsha Vijaya, Ruppert, Jan Gustav, Ray, Suparna, Wenzel, Eva Maria, Behrens, Jürgen

“…Truncating mutations affect the adenomatous polyposis coli (APC) gene in most cases of colon cancer, resulting in the stabilization of β-catenin and uncontrolled cell proliferation. We show here that colon cancer cell lines express also the paralog APC-like (APCL or APC2). …”
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