Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell by Asial, Ignacio, Cheng, Yue Xiang, Engman, Henrik, Dollhopf, Maria, Wu, Binghuang, Nordlund, Pär, Cornvik, Tobias

“…Unfortunately, identifying stabilizing mutations is not trivial since most are neutral or deleterious. Here we describe a high-throughput colony-based stability screen, which is a direct and biophysical read-out of intrinsic protein stability in contrast to traditional indirect activity-based methods. …”
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Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains by Ma, Yue, Iida, Keisuke, Sasaki, Shogo, Hirokawa, Takatsugu, Heddi, Brahim, Nagasawa, Kazuo, Phan, Anh Tuân

“…G-quadruplexes (G4s), which are structures formed in guanine-rich regions of DNA, are involved in a variety of significant biological functions, and therefore “sequence-dependent” selective G4-stabilizing agents are required as tools to investigate and modulate these functions. Here, we describe the synthesis of a new series of macrocyclic hexaoxazole-type G4 ligand (6OTD) bearing three side chains. …”
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A multimodal approach to analysis of steady state visually evoked potentials by Vij, Nikhil, Zuobin, Wu, Bjornsdotter, Malin, Dauwels, Justin, Vialatte, François-Benoît

“…Steady state visually evoked potentials (SSVEPs), recorded from the central nervous system of humans using electroencephalography (EEG) in response to visual stimuli, have recently gained attention in cognitive and clinical neuroscience [1]. Here, we fuse EEG SSVEPs with recordings from functional magnetic resonance imaging data (fMRI) utilizing the millisecond temporal resolution of the former and the excellent spatial resolution of the latter. …”
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Dielectric metamaterials with toroidal dipolar response by Economou, Eleftherios N., Soukoulis, Costas M., Fedotov, Vassili A., Savinov, Vassili, Zheludev, Nikolay I., Basharin, Alexey A., Kafesaki, Maria

“…Toroidal multipoles are the terms missing in the standard multipole expansion; they are usually overlooked due to their relatively weak coupling to the electromagnetic fields. Here, we propose and theoretically study all-dielectric metamaterials of a special class that represent a simple electromagnetic system supporting toroidal dipolar excitations in the THz part of the spectrum. …”
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Graphite oxide to graphene. Biomaterials to bionics by Thompson, Brianna Clair, Murray, Eoin, Wallace, Gordon G.

“…The rich chemistries available are able to ensure properties uncovered in the nanodomain are conveyed into the world of macroscopic devices. Here, the inherent properties of graphene, along with how graphene or structures containing it interface with living cells and the effect of electrical stimulation on nerves and cells, are reviewed.…”
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Influence of no-core fiber on the focusing performance of an ultra-small gradient-index fiber probe by Bi, Shubo, Wang, Chi, Zhu, Jun, Yuan, Zhiwen, Yu, Yingjie, Valyukh, Sergiy, Asundi, Anand

“…For the parameters of the fiber probe studied here, the effective beam expansion length of the no-core fiber spacer is less than 0.357 mm.…”
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MMP14 in sarcoma : a regulator of tumor microenvironment communication in connective tissues by Gonzalez-Molina, Jordi, Gramolelli, Silvia, Liao, Zehuan, Carlson, Joseph W., Ojala, Päivi M., Lehti, Kaisa

“…Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas.…”
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Effect of oblique retroreflection from a vibrating mirror on laser Doppler shift by Agusanto, Kusuma, Lau, Gih-Keong, Liu, Ting, Zhu, Chuangui

“…However, the reading of LDV obtained from the recovered signal is not right because the retroreflection adds extra Doppler frequency shifts to the oblique reflection. Here, we first derive the relationship of Doppler shift to the oblique angle of retroreflection. …”
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Generation of vascularized 3-dimensional (3D) kidney organoids from human pluripotent stem cells by Low, Jian Hui

“…However, intrinsic limitations such as efficiency and a lack of control over the cell types differentiating within, hamper their full utility. Here, we present the establishment of a highly efficient protocol for differentiating hPSCs into kidney organoids comprised of segmented nephrons, vasculature, and interstitial cells. …”
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Nonlinear spin filter for non-magnetic materials at zero magnetic field by Marcellina, Elizabeth, Srinivasan, Ashwin, Nichele, Fabrizio, Stano, Peter, Ritchie, David A., Farrer, Ian, Culcer, Dimitrie, Hamilton, Alexander R.

“…In semiconductors, spin-to-charge conversion is typically achieved using the inverse spin Hall effect or using a large magnetic field. Here we demonstrate a general method that exploits the nonlinear interactions between spin and charge currents to perform all-electrical, rapid, and noninvasive detection of spin accumulation without the need for a magnetic field. …”
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The role of mainstreamness and interdisciplinarity for the relevance of scientific papers by Thurner, Stefan, Liu, Wenyuan, Klimek, Peter, Cheong, Siew Ann

“…Is it possible to tell how interdisciplinary and out-of-the-box scientific papers are, or which papers are mainstream? Here we use the bibliographic coupling network, derived from all physics papers that were published in the Physical Review journals in the past century, to try to identify them as mainstream, out-of-the-box, or interdisciplinary. …”
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Highly conductive aligned carbon film for interconnect application by Li, Fushan, Shakerzadeh, Maziar, Tan, Chong Wei, Yu, Hongyu, Tay, Beng Kang

“…We demonstrate here an amorphous carbon film with a highly conductive transition phase for interconnect application. …”
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Ethics education for successful infectious disease control of COVID-19 by Lim, Hannah Yeefen

“…There have been significant problems with leaders and citizenry deliberately ignoring and not complying with such measures and which have directly resulted in sudden rises in infection numbers. Here, I show the nature and extent of the widespread problem and argue that the problem is in large part due to our modern society characterised by liberal individualism. …”
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A model of P2P energy trading for active distribution network based on cooperative game by Li, Yiyang

“…In order to solve these problems, this project introduces the concept of Agent to manage the power consumption and transaction in local areas and establishes a Peer-to-Peer (P2P) energy trading framework where Agents work as transaction individuals representing residential electric power consumers. Here, users can choose whether to trade with a power grid company or other users from the perspective of economic interests. …”
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Shape control in surface patterning atop shape memory polymers via indentation, polishing and shape recovery by Prasad, Ayush, Huang, Wei Min

“…Hence the results can be scaled. The trends obtained here should be applicable to other shape memory polymers.…”
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Electrochemical impedance analysis of thermogalvanic cells by Yang, Peihua, Fan, Hong Jin

“…However, the electron transfer kinetics and mass transfer of redox couples have not been thoroughly studied. Here, the ion reaction and charge transport in thermogalvanic cells are investigated by electrochemical impedance analysis. …”
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Surface-enhanced Raman scattering (SERS) spectroscopy platforms for enhanced detection at the nanobio interface: from metabolites to microorganisms by Leong, Shi Xuan

“…In this thesis, we overcome these roadblocks by synergizing designer plasmonic platforms with emerging strategies to expand the analyte scope, ranging from small-molecule metabolites to microorganisms. Here, we successfully design direct enantiospecific nanoparticle-analyte interactions for label-free, generic chiral differentiation. …”
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Aerodynamics of unconventional airfoils by Ng, Bing Feng.

“…As such, it will be shown here that static LEVs can be created and trapped through the use of cavities. …”
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Ergative in Mi=la=ras=pa'i rnam thar by Saxena, Anju

“…One of the limitations of working with a text is the nonavailability of all types of constructions that one would like in order to verify the claims; thus the suggestions made here should be taken as tentative.…”
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Modeling and control of an air handling unit using dynamic fuzzy neural networks by Kothandaraman Neelanarayanan.

“…After the introduction of the Artificial Intelligence (Al), their concepts are getting popular in every aspect of engineering, manufacturing, knowledge discovery systems and data mining applications. Here in our work, Artificial Intelligence concepts are being applied to model and control the Air Handling units to have better control and include intelligence to such control systems. …”
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