Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8⁺ T cells by Kang, Xing, Liu, Changan, Ding, Yanqiang, Ni, Yunbi, Ji, Fenfen, Lau, Harry Cheuk Hay, Jiang, Lanping, Sung, Joseph Jao Yiu, Wong, Sunny Hei, Yu, Jun

“…R. intestinalis or butyrate also significantly improved antiprogrammed cell death protein 1 (anti-PD-1) efficacy in mice bearing MSI-low CT26 tumours. Mechanistically, butyrate directly bound to toll-like receptor 5 (TLR5) receptor on CD8(+) T cells to induce its activity through activating nuclear factor kappa B (NF-& kappa;B) signalling. …”
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Patient-Centered Clinical Trial Design for Heart Failure Devices via Bayesian Decision Analysis by Chaudhuri, Shomesh E., Adamson, Phillip, Bruhn-Ding, Dean, Ben Chaouch, Zied, Gebben, David, Rincon-Gonzalez, Liliana, Liden, Barry, Reed, Shelby D., Saha, Anindita, Schaber, Daniel, Stein, Kenneth, Tarver, Michelle E., Lo, Andrew W.

“…This result reflects the willingness of heart failure patients to bear additional risks of the investigational device in exchange for its probable benefits. …”
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Towards Synergistic Understanding of Language Processing in Biological and Artificial Systems by Hosseini Asl, Eghbal

“…Over the past five years, artificial neural networks (ANNs) have achieved capabilities in the comprehension and production of language that are indistinguishable from those of humans, and their internal representations bear similarity to activity within the language network. …”
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Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

“…In studies with A549 tumor-bearing mice, the combination of low-dose 2-DG and metformin did not impede tumor growth, whereas 2-DG@MA-dots markedly decreased tumor volume, with the mean final tumor volume in the combination treatment group being approximately 89 times greater than that in the 2-DG@MA-dot group. …”
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Comparison of transport methodologies on near-field pollutant dispersion in urban environments using CFD by Tee, Clarence Wei Tat

“…The two methodologies are validated by simulating the dispersion phenomena for two test cases which largely bear resemblance to urban settings: a three-dimensional street canyon setup and the Mock Urban Setting Test (MUST) field experiment. …”
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Progressive collapse behaviour of precast concrete structures with advanced joints by Nguyen, Van Hung

“…Secondly, the pull-out test results highlighted a pivotal role of bearing force in anchorage strength of headed bars and strain behaviour. …”
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Synthesis of heavy cyanide analogs for the design of novel Prussian blue analogs by Yang, E

“…In order to provide illustrative points of comparison, analogous metal complexes bearing various strong-field ligands are also synthesized and analyzed using the same approach.…”

Bacteria-mediated anti-cancer therapy by Bhave, Madhura Satish

“…However, IB significantly inhibited the growth of the tumors and improved the survival rate of immunocompetent CT26 tumor-bearing mice. Histological analysis showed that IB increased the necrotic area in HCT116 tumors. …”
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Export competitiveness in the context of Singapore by Chew, Kheng Lee, Phua, Chin Tiong, Yau, Puay Hiang

“…Last but not least, we must bear in mind that Singapore is only a small economy. …”
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Fabrication and characterization of graphene and carbon nanotube reinforced bioceramic nanocomposites by Hu, Huanlong

“…Bioceramics play an important role in the replacement and regeneration of human tissues, but their intrinsic brittleness and low wear resistance make the monolithic bioceramics still problematic for load-bearing applications. The two dimensional (2D) graphene and one dimensional (1D) carbon nanotube (CNT), as the secondary strong and tough biocompatible nanofillers, are popular nanocarbons to reinforce bioceramics. …”
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Engineered terahertz emission from spintronic heterostructures: amplitude, phase and chirality by Agarwal, Piyush

“…To summarize, the thesis aims to contribute to the synergies of spintronics and photonics for advanced applications in developing scalable devices bearing low-cost fabrication with on-chip compatibility.…”
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