Development of the CHARIOT Research Register for the Prevention of Alzheimer’s Dementia and Other Late Onset Neurodegenerative Diseases by Larsen, Mark E., Curry, Lisa, Mastellos, Nikolaos, Robb, Catherine, Car, Josip, Middleton, Lefkos T.

“…The success of this research is dependent on having access to a well characterised, representative and sufficiently large population of individuals. …”
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Controlled self-assembly of Ni foam supported poly(ethyleneimine)/reduced graphene oxide three-dimensional composite electrodes with remarkable synergistic effects for efficient ox... by Zhao, Ming, Yuan, Weiyong, Li, Chang Ming

“…The optimum one achieves the current density of 10 mA cm−2 at an overpotential of 322 mV, which is lower than those of most reported transition metal-based OER catalysts and non-metal ones as well as those of state-of-the-art Ir/C, Ru/C, IrO2/C, and RuO2 measured under the same conditions (0.1 M KOH). …”
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A unified framework of active transfer learning for cross-system recommendation by Zhao, Lili, Pan, Sinno Jialin, Yang, Qiang

“…To address this issue, one of the most effective practices is applying transfer learning techniques by leveraging relatively rich collaborative data knowledge from related systems, which have been well running. Previous transfer learning models for recommender systems often assume that a sufficient set of entity correspondences (either user or item) across the target and auxiliary systems (a.k.a. source systems) is given in advance. …”
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Toward a neuroscientific understanding of play: a dimensional coding framework for analyzing infant–adult play patterns by Neale, Dave, Clackson, Kaili, Georgieva, Stanimira, Dedetas, Hatice, Scarpate, Melissa, Wass, Sam, Leong, Victoria

“…Play during early life is a ubiquitous activity, and an individual’s propensity for play is positively related to cognitive development and emotional well-being. Play behavior (which may be solitary or shared with a social partner) is diverse and multi-faceted. …”
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Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation by Chu, Trang T. T., Sinha, Ameya, Malleret, Benoit, Suwanarusk, Rossarin, Park, Jung Eun, Naidu, Renugah, Das, Rupambika, Dutta, Bamaprasad, Ong, Seow Theng, Verma, Navin Kumar, Chan, Jerry K., Nosten, François, Rénia, Laurent, Sze, Siu Kwan, Russell, Bruce, Chandramohanadas, Rajesh

“…While most structural proteins (such as Spectrins, Ankyrin and Band 3) as well as surface glycoproteins were conserved, proteins associated with microtubule structures, such as Talin-1/2 and ß-Tubulin, were detected only in immature reticulocytes. …”
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Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype by de Vos, Ivo J. H. M., Goggi, Julian L., Wilson, Gabrielle R., Stegmann, Alexander P. A., Amor, David J., Dunn, Norris Ray, Carney, Thomas James, Lockhart, Paul J., Coull, Barry J., van Steensel, Maurice A. M., Tao, Evelyn Yaqiong, Ong, Sheena Li Ming, Scerri, Thomas, Low, Chernis Guai Mun, Wong, Arnette Shi Wei, Grussu, Dominic, van Geel, Michel, Janssen, Renske, Bahlo, Melanie

“…Based on our observations as well as previously published data, we hypothesize that MMP14’s catalytic activity is the prime determinant of disease severity. …”
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Performance analysis of IEEE 802.11p safety message broadcast with and without relaying at road intersection by Md. Noor-A-Rahim, G. G. Md. Nawaz Ali, Nguyen, Hieu, Guan, Yong Liang

“…In a highway scenario, it is often been considered that all the vehicles have the same communication range as well as the same carrier sensing range. However, this is not the case for the intersection scenario, where there exist a lot of obstructions, such as buildings and urban canyons. …”
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Operator-based truncation scheme based on the many-body fermion density matrix by Henley, Christopher L., Cheong, Siew Ann

“…This performance was compared against that of the traditional density-matrix-based truncation scheme, as well as against an operator-based plane-wave truncation scheme, and found to be very satisfactory.…”
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Ultra low-voltage low-power CMOS 4-2 and 5-2 compressors for fast arithmetic circuits by Chang, Chip Hong, Gu, Jiang Min, Zhang, Mingyan

“…Driving capability has been considered in the design as well as in the simulation setup so that these 4-2 and 5-2 compressor cells can operate reliably in any tree structured parallel multiplier at very low supply voltages. …”
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NALPS : a precisely dated European climate record 120–60 ka by Wang, X., Cheng, Hai, Spötl, C., Edwards, R. Lawrence, Boch, R., Häuselmann, Ph

“…NALPS resolves recurrent short-lived climate changes within the cold Greenland stadial and warm interstadial successions, i.e. abrupt warming events preceding GI 21 and 23 (precursor-type events) and at the end of GI 21 and 25 (rebound-type events), as well as intermittent cooling events during GI 22 and 24. …”
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Enhancing E. coli tolerance towards oxidative stress via engineering its global regulator cAMP Receptor Protein (CRP) by Basak, Souvik, Jiang, Rongrong

“…OM3 also elicited enhanced thermotolerance at 48°C as well as resistance against cumene hydroperoxide. …”
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Monocyte-derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF‐β1 by Ansa-Addo, Ephraim A., Pathak, Paras, McCrossan, Maria V., Volpato Rossi, Izadora, Abdullahi, Mahamed, Stratton, Dan, Lange, Sigrun, Ramirez, Marcel I., Inal, Jameel

“…Host cell lEVs were released through Mtr interaction with host cell lipid raft domains, integrins, and mechanosensitive ion channels, whereupon [Ca2+]cyt increased (50 to 750 nM) within 15 s. lEV release and cell entry of T. cruzi, which increased up to 30 and 60 mpi, respectively, as well as raised actin depolymerization at 60 mpi, were all reduced by TRPC inhibitor, GsMTx‐4. …”
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Granulocyte-macrophage colony-stimulating factor neutralisation in patients with axial spondyloarthritis in the UK (NAMASTE): a randomised, double-blind, placebo-controlled, phase... by Worth, C, Al-Mossawi, MH, MacDonald, J, Fisher, BA, Chan, A, Sengupta, R, Packham, J, Gaffney, K, Gullick, N, Cook, JA, Corn, TH, Teh, J, Machado, PM, Taylor, PC, Bowness, P

“…<p><strong>Interpretation</p></strong> Namilumab did not show efficacy compared with placebo in patients with active axial spondyloarthritis, but the treatment was generally well tolerated. <p><strong>Funding</p></strong> Izana Bioscience, NIHR Oxford Biomedical Research Centre (BRC), NIHR Birmingham BRC, and Clinical Research Facility.…”

Electrochemical modification of electrodes with metal nanoparticles by Mavrokefalos, C

“…The surface chemistry of the aforementioned electrodes was modified utilising such strategies as electrochemical and hydrogen plasma treatment as well as coating treatment. Extended attention was paid to metal alloys and/or core-shell metal nanostructures. …”

Spin-ice physics and phase transitions in cadmium cyanide by Coates, CS

“…The structure of previously-unreported intermediate phase, Cd(NH₃)₂[Cd(CN)₄], is characterised, as well as its thermomechanical response. This represents the first variable-temperature study of this type of framework (PtS), shown to display anisotropic NTE and negative linear compressibility. …”

Cadê o Kauê? Co-design and acceptability testing of a chat-story aimed at enhancing youth participation in the promotion of mental health in Brazil by Pavarini, G, Murta, SG, Mendes, JAA, Siston, FR, Souza, RRA, Cunha, RO, Ferreira, JA, Santos, VHL, Seabra, BTR, Talk2U, Singh, I

“…</p> <p><strong>Conclusions:&nbsp;</strong>The immersive co-creation model, enriched by input from key stakeholders, yielded a relevant and well-received intervention for Brazilian adolescents. …”

Acquisition of musical skills and abilities in older adults—results of 12 months of music training by Losch, H, Altenmüller, E, Marie, D, Passarotto, E, Kretschmer, CR, Scholz, DS, Kliegel, M, Krüger, THC, Sinke, C, Jünemann, K, James, CE, Worschech, F

“…Practicing a musical instrument has been identified as a promising activity for improving cognition, promoting well-being, and inducing brain plasticity in older individuals. …”

Probabilistic verification beyond context-freeness by Li, G

“…The study discusses the mutual conversions between rPTSA and PAHORS, as well as conversions from other models of interest, such as pPDA and Stochastic MCFG, to rPTSA.…”

Magrolimab in combination with azacitidine in patients with higher-risk myelodysplastic syndromes: final results of a phase Ib study by Sallman, DA, Al Malki, MM, Asch, AS, Wang, ES, Jurcic, JG, Bradley, TJ, Flinn, IW, Pollyea, DA, Kambhampati, S, Tanaka, TN, Zeidner, JF, Garcia-Manero, G, Jeyakumar, D, Komrokji, R, Lancet, J, Kantarjian, HM, Gu, L, Zhang, Y, Tan, A, Chao, M, O'Hear, C, Ramsingh, G, Lal, I, Vyas, P, Daver, NG

“…</p> <br> <p><strong>Conclusion:</strong> Magrolimab + azacitidine was well tolerated with promising efficacy in patients with untreated higher-risk MDS, including those with TP53 mutations. …”

The association between hip morphology parameters and 19-year risk of end-stage osteoarthritis of the hip in caucasian females: a case-control study by Nicholls, AS

“…</p> <p>Following validation of the new software, a nested case-control study was used with individuals from a well-described cohort of 1003 caucasian women who were recruited in 1989 and followed up for 20 years. …”