Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy by Leylek, Ozen, Honeywell, Megan E., Lee, Michael J., Hemann, Michael T., Ozcan, Gulnihal

“…We validated the synergy in cell death using fluorescence-based and lysis-dependent inference of cell death kinetics assay, and validated the genetic dependencies by single-gene knockout experiments. …”
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Ecological forces affecting microbial eukaryotes in the coastal ocean by Gomez, Annika L.

“…We show that sinking velocity can be modulated by nutrient limitations via the accumulation of carbohydrates which increase cell density. These results demonstrate that in addition to cell growth, nutrient limitation can also affect vertical stratification within phytoplankton populations. …”
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Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death by Martínez, Pablo, Silva, Mónica, Abarzúa, Sebastián, Tevy, María F., Jaimovich, Enrique, Constantine-Paton, Martha, Bustos, Fernando J., van Zundert, Brigitte

“…A large body of evidence shows that astrocytes expressing ALS-linked mutant proteins cause non-cell autonomous toxicity of MNs. Although MNs innervate muscle fibers and ALS is characterized by the early disruption of the neuromuscular junction (NMJ) and axon degeneration, there are controversies about whether muscle contributes to non-cell-autonomous toxicity to MNs. …”
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Towards a Single Bio-molecule Detector Based on CMOS Nanofluidic Platform by Zikrallah, Ahmed S.

“…Cytokines secretion is a core component of the function of many cell therapy products: It affects the tissue repair capacity of induced Pluripotent Stem Cells (iPSCs) and Mesenchymal Stem cells (MSCs) and the tumorigenicity of Chimeric Antigen Receptor (CAR) T-cell therapies. …”
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The gut microbiota and developmental programming of the testis in mice by Al-Asmakh, Maha, Stukenborg, Jan-Bernd, Reda, Ahmed, Anuar, Farhana, Strand, Mona-Lisa, Hedin, Lars, Pettersson, Sven, Söder, Olle

“…Reduced expressions of occludin, ZO-2 and E-cadherin in GF testis suggested that the microbiota modulated BTB permeability by regulation of cell-cell adhesion. Interestingly, exposure of GF mice to Clostridium Tyrobutyricum (CBUT), which secrete high levels of butyrate, restored the integrity of the BTB and normalized the levels of cell adhesion proteins. …”
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Chromatin laser imaging reveals abnormal nuclear changes for early cancer detection by Chen, Yu-Cheng, Chen, Qiushu, Tan, Xiaotain, Chen, Grace, Bergin, Ingrid, Muhammad Nadeem Aslam, Fan, Xudong

“…We developed and applied rapid scanning laser-emission microscopy (LEM) to detect abnormal changes in cell nuclei for early diagnosis of cancer and cancer precursors. …”
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Halide perovskite-based indoor photovoltaics: recent development and challenges by Bening Tirta Muhammad, Kar, Shaoni, Stephen, Meera, Leong, Wei Lin

“…Metal halide perovskite solar cell (PSC) technology is yet to make its way to enter the outdoor solar energy harvesting market as a single junction or a tandem cell; recent studies have already sparked huge interest in PSC for indoor photovoltaic (iPV) applications. …”
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Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX by Ma, Jiajia, Scott, Claire A., Ho, Ying Na, Mahabaleshwar, Harsha, Marsay, Katherine S., Zhang, Changqing, Teow, Christopher K. J., Ng, Ser Sue, Zhang, Weibin, Tergaonkar, Vinay, Partridge, Lynda J., Roy, Sudipto, Amaya, Enrique, Carney, Tom J.

“…Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such responses are also elicited upon overexpression of the membrane-bound protease, Matriptase, or mutation of its inhibitor, Hai1. …”
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Vypal2: a versatile peptide ligase for precision tailoring of proteins by Zhang, Dingpeng, Wang, Zhen, Hu, Side, Lescar, Julien, Tam, James P., Liu, Chuan-Fa

“…We also demonstrated on-cell labelling of protein ligands pre-bound to cellular receptors and cell-surface engineering via modifying a covalently anchored peptide substrate pre-installed on cell-surface glycans. …”
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Identification of GABAergic neurons innervating the zebrafish lateral habenula by Ramaswamy, Mahathi, Cheng, Ruey-Kuang, Jesuthasan, Suresh

“…GAD65/67 immunohistochemistry and imaging of gad1b:DsRed transgenic fish suggest the presence of GABAergic terminals in the neuropil and between cell bodies in the lateral habenula. Retrograde tracing with the lipophilic dye DiD suggests that the former derives from the thalamus, while the latter originates from a group of cells in the posterior hypothalamus that are located between the posterior tuberal nucleus and hypothalamic lobes. …”
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Dynamically-biased fixed-point LSTM for time series processing in AIoT edge device by Hu, Jinhai, Goh, Wang Ling, Gao, Yuan

“…Hence, a DB-LSTM cell contains information of both the previous output and the current cell state. …”
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Design and development of a biopolymer microfiber fabrication device by Yap, Yi-Liang.

“…This is done by culturing cells on a biodegradable scaffold. Existing approach generally involves in vitro culture of cell before in vivo implantation of the cell-scaffold construct. …”
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The central element of the synaptonemal complex in mice is organized as a bilayered junction structure by Hernández-Hernández, Abrahan, Masich, Sergej, Fukuda, Tomoyuki, Kouznetsova, Anna, Sandin, Sara, Daneholt, Bertil, Höög, Christer

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Inflammation and colorectal cancer: elucidation of the cellular and molecular mechanisms by which interleukin 22 contributes to the development and progression of colorectal cancer by McCuaig, S

“…Taking unbiased RNA-sequencing and proteomic approaches, we identified non-cell autonomous and cell autonomous pathways by which IL-22 may interact with <em>KRAS</em> to promote malignancy. …”

The ISB Arrests: The Transnational Terrorist “Insider Threat” by Kumar Ramakrishna

“…The recent arrests of an eight-man cell of Bangladeshi migrant workers calling itself the Islamic State of Bangladesh illustrates the reality and potential of the “insider threat” of transnational terrorism.…”
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Towards Health Centered Drug Policy: An Analysis of Past and Developing Drug Policy by Lewis, Benjamin B.

“…We estimate the causal effect of each policy separately for each state, and then use meta-analysis to calculate the overall effect of each policy intervention. …”
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Decoding divergence in marine protistan communities: from strain diversity to basin biogeography by Krinos Quinn, Arianna Isabella

“…Scalable workflows highlight the challenge and promise of meta-omic data to link community structure to physiology. …”
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Applying a nanoparticle@mof interface to activate an unconventional regioselectivity of an inert reaction at ambient conditions by Lee, Hiang Kwee, Koh, Charlynn Sher, Lo, Wei-Shang, Liu, Yejing, Phang, In Yee, Sim, Howard Yi, Lee, Yih Hong, Phan-Quang, Gia Chuong, Tsung, Chia-Kuang, Ling, Xing Yi

“…Notably, we observe an unprecedented CO₂ meta-carboxylation of an arene that was previously deemed impossible in traditional Kolbe-Schmitt reactions. …”
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React based web-application for stock price forecasting with a novel stacking algorithm by Mittal, Madhav

“…It proposes a novel ensemble using model stacking, that utilizes XgBoost, Supported Vector Regressor and Linear Regressor as the base models, and Linear Regressor as the meta-learner. It is concluded that this ensemble outperforms all the other models tested in the paper. …”
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Are tai chi and qigong effective in the treatment of TBI? A systematic review protocol by Laskosky, Nicole Alexandra, Huston, Patricia, Lam, Wai Ching, Anderson, Charlotte, Zheng, Ya, Zhong, Linda Lidan

“…Method: Designed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the following databases will be searched: MEDLINE, CINAHL, Cochrane Library, Embase, China National Knowledge Infrastructure Database, Wanfang Database, Chinese Scientific Journal Database, and Chinese Biomedical Literature Database. …”
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