From 2D to 3D: development of monolayer dopaminergic neuronal and midbrain organoid cultures for Parkinson's disease modeling and regenerative therapy by Yeap, Yee Jie, Tng, Teddy J. W., Lee, Mok Jung, Goh, Micaela, Lim, Kah-Leong

“…Despite intensive research, the etiology of PD is currently unresolved, and the disease remains incurable. …”
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PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder by Wang, L

“…</p> <p>Overall, these data have implications both for the etiology of PCNA-associated repair disorder as well as suggesting novel circumstances in which PARP-inhibition might be of use in the cancer clinic. …”

Operation and control of PEM fuel cell system by Tan, Chun Xu.

“…Hence, the use of the fuel cell based power system for residential or industrial application is expected to be more prevalent in the near future due to improved power quality, reliability, portability and sustainability of the ecology system. However, integration of a variety of small-size distributed generators is changing the traditional structure of electric power distribution systems and affecting system dynamics, whose main source of power supply is the substation. …”
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A risk assessment of Pseudomonas aeruginosa in swimming pools : a review by Rice, Scott A., Akker, Ben van den, Pomati, Francesco, Roser, David

“…This review was undertaken to identify the current understanding of risk factors associated with pool operation with respect to P. aeruginosa. The ecology and factors that promote growth of P. aeruginosa in the pool environment are complex and dynamic and so we applied a systematic risk assessment approach to integrate existing data, with the aim to improve pool management and safety. …”
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Random walk models in the life sciences: including births, deaths and local interactions by Plank, M, Simpson, M, Baker, R

“…Random walks and related spatial stochastic models have been used in a range of application areas, including animal and plant ecology, infectious disease epidemiology, developmental biology, wound healing and oncology. …”

Copper metabolism in the plaice, Pleuronectes platessa (L.) by Syed, M.Arif, Coombs, Thomas L.

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A comparison of the flavonoids in Athyriaceae and Aspleniaceae by Umikalsom, Y., Grayer-Barkmeijer, Renée J., Harborne, Jeffrey B.

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Infectious diseases acquired by international travellers visiting the USA by Stoney, Rhett J, Esposito, Douglas H., Kozarsky, Phyllis, Hamer, Davidson H., Grobusch, Martin P., Gkrania-Klotsas, Effrossyni, Libman, Michael, Gautret, Philippe, Lim, Poh Lian, Leder, Karin, Schwartz, Eli, Sotir, Mark J., Licitra, Carmelo

“…Travellers presented with a range of illnesses; skin and soft tissue infections of unspecified aetiology were the most frequently reported during travel (29 diagnoses, 14% of during-travel diagnoses); arthropod bite/sting was the most frequently reported after travel (173 diagnoses, 15% after-travel diagnoses). …”
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Diauxic lags explain unexpected coexistence in multi‐resource environments by Bloxham, Blox, Lee, Hyunseok, Gore, Jeff

“…How the coexistence of species is affected by the presence of multiple resources is a major question in microbial ecology. We experimentally demonstrate that differences in diauxic lags, which occur as species deplete their own environments and adapt their metabolisms, allow slow‐growing microbes to stably coexist with faster‐growing species in multi‐resource environments despite being excluded in single‐resource environments. …”
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Advancing nature-based solutions through enhanced soil health monitoring in the United Kingdom by Giuliani, LM, Warner, E, Campbell, GA, Lynch, J, Smith, AC, Smith, P

“…To address this, we propose a flexible, interdisciplinary approach combining soil science, ecology and socio-economic insights. We introduce an interactive tool to help users select suitable soil and biodiversity metrics which are context and scalespecific, and suggest avenues for future research. …”

Relational persistent homology for multispecies data with application to the tumor microenvironment by Stolz, BJ, Dhesi, J, Bull, JA, Harrington, HA, Byrne, HM, Yoon, IHR

“…Such heterogeneous data types arise in many contexts, ranging from biomedical imaging, geospatial analysis, to species ecology. Here, we propose two methods for encoding spatial relations among different data types that are based on Dowker complexes and Witness complexes. …”

Three year performance of international provenance trials of Acacia auriculiformis by Awang, Kamis, Venkateswarlu, Perugupalli, Abd.Shukor, Nor Aini, Adjers, Goran, Bhumibhamon, Suree, Kietvuttinon, Bopit, Pan, Fuh-Juinn, Pitpreecha, Kiatkong, Simsiri, Apisit

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Review of mid-infrared mode-locked laser sources in the 2.0 μ m–3.5 μ m spectral region by Ma, Jie, Qin, Zhipeng, Xie, Guoqiang, Qian, Liejia, Tang, Dingyuan

“…These achievements open new opportunities for applications in areas such as molecular spectroscopy, frequency metrology, material processing, and medical diagnostics and treatment. …”
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Expediting treatments in the 21st century: orphan drugs and accelerated approvals by Domike, Reuben, Raju, G. K., Sullivan, Jamie, Kennedy, Annie

“…The re-use of surrogate markers for oncological diseases has been an advantage in a way that may not be scientifically feasible in many other disease areas that have greater differentiation across disease etiology. For non-oncological diseases, applicability of AA is, in part, dependent upon greater focus on characterization and acceptance of novel surrogate markers.…”
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First international conference on RASopathies and neurofibromatoses in Asia : identification and advances of new therapeutics by Rauen, Katherine A, Alsaegh, Abeer, Ben-Shachar, Shay, Berman, Yemima, Blakeley, Jaishri, Cordeiro, Isabel, Elgersma, Ype, Evans, D Gareth, Fisher, Michael J, Frayling, Ian M, George, Joshi, Huson, Susan M, Kerr, Bronwyn, Khire, Uday, Korf, Bruce, Legius, Eric, Messiaen, Ludwine, van Minkelen, Rick, Nampoothiri, Sheela, Ngeow, Joanne, Parada, Luis F, Phadke, Shubha, Pillai, Ashok, Plotkin, Scott R, Puri, Ratna, Raji, Anup, Ramesh, Vijaya, Ratner, Nancy, Shankar, Suma P, Sharda, Sheetal, Tambe, Anant, Vikkula, Miikka, Widemann, Brigitte C, Wolkenstein, Pierre, Upadhyaya, Meena

“…Due to their common underlying pathogenetic etiology, all these syndromes have significant phenotypic overlap of which one common feature include a predisposition to tumors, which may be benign or malignant. …”
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Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging by Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y., Poh, Luting, Jo, Dong-Gyu, Herr, Deron R., Zhang, Shenpeng R., Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K. P., Chen, Christopher Li- Hsian, Drummond, Grant R., Lim, Kah-Leong, Sobey, Christopher G., Arumugam, Thiruma V.

“…Vascular dementia (VaD) is a progressive cognitive impairment of vascular etiology. VaD is characterized by cerebral hypoperfusion, increased blood-brain barrier permeability and white matter lesions. …”
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Remote digital cognitive assessment reveals cognitive deficits related to hippocampal atrophy in autoimmune limbic encephalitis: a cross-sectional validation study by Shibata, K, Attaallah, B, Tai, X-Y, Trender, W, Hellyer, PJ, Hampshire, A, Irani, SR, Manohar, SG, Husain, M

“…<p><strong>Background:</strong> Autoimmune limbic encephalitis (ALE) is a neurological disease characterised by inflammation of the limbic regions of the brain, mediated by pathogenic autoantibodies. …”

Social wasps desert the colony and aggregate outside if parasitized: parasite manipulation? by Hughes, DP, Kathirithamby, J, Turillazzi, S, Beani, L

“…Hamilton, these aberrant aggregations are an overlooked phenomenon of the behavioral ecology of this intensively studied wasp. For 3 months in the summer of 2000, during the peak of colony development, we sampled 91 extranidal aggregations from seven areas, numbering 1322 wasps. …”

Animal social networks are robust to changing association definitions by Chan, AHH, Dunning, J, Beck, KB, Burke, T, Chik, HYJ, Dunleavy, D, Evans, T, Ferreira, A, Fourie, B, Griffith, SC, Hillemann, F, Schroeder, J

“…We urge researchers to carefully evaluate the ecological context of their study systems when making methodological decisions. …”

Practices, attitudes and motives for domestic waste recycling by Aini, M. S., Fakhru'l-Razi, A., Lad, S. M., Hashim, A. H.