Frataxin deficiency promotes endothelial senescence in pulmonary hypertension

“…These findings also establish an endothelial etiology for PH in FRDA and left heart disease and support therapeutic development of senolytic drugs, reversing effects of Fe-S deficiency across PH subtypes.…”
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Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity by Tang, Tommy Hing-Cheung, Alonso, Sylvie, Ng, Lisa Fong-Poh, Thein, Tun-Linn, Pang, Vincent Jun-Xiong, Leo, Yee-Sin, Lye, David Chien-Boon, Yeo, Tsin-Wen

“…Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. …”
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Systematic assessment of COVID-19 host genetics using whole genome sequencing data by Schmidt, A, Casadei, N, Brand, F, Demidov, G, Vojgani, E, Abolhassani, A, Aldisi, R, Butler-Laporte, G, DeCOI host genetics group, Alawathurage, TM, Augustin, M, Bals, R, Bellinghausen, C, Berger, MM, Bitzer, M, Bode, C, Boos, J, Brenner, T, Cornely, OA, Eggermann, T, Erber, J, Feldt, T, Fuchsberger, C, Gagneur, J

“…By enabling joint analyses of different types of variation across the entire frequency spectrum, this data will continue to contribute to the elucidation of COVID-19 etiology.…”

Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1 by Ramirez-Franco, J, Debreux, K, Extremet, J, Maulet, Y, Belghazi, M, Villard, C, Sangiardi, M, Youssouf, F, El Far, L, Lévêque, C, Debarnot, C, Marchot, P, Paneva, S, Debanne, D, Russier, M, Seagar, M, Irani, SR, El Far, O

“…To investigate whether the cellular and subcellular distribution of LGI1 may explain the localization of these features, and hence gain broader insights into LGI1's neurobiology, we analysed the detailed localization of LGI1 and the diversity of its protein interactome, in mouse brains using patient-derived recombinant monoclonal LGI1 antibodies. …”

Fairy lanterns in focus by Thorogood, CJ, Yunoh, S-MM

“…<p>So-called fairy lanterns (<em>Thismia</em>) are among the most extraordinary flowering plants, yet little is known about their ecology. There has been a spate of recent species discoveries revealing a bewildering diversity of flower forms. …”

Molecular genetics of Dupuytren’s contracture by Aissvarya, Shankar, Ling, King-Hwa, Arumugam, Manohar, Thilakavathy, Karuppiah

“…Most reports are backdated making it necessary to re-evaluate the variants to further understand the genetic aetiology of DC. • In this review, we first highlight the genetic aspects and previous genetic studies on DC. …”
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Design of an eco-friendly vegetable/flower bed for the HDB balcony by Chang, Cheng Hung.

“…The purpose of designing an ecology-friendly flower bed in HDB flat is mainly to provide a more convenient method for folks in the city to grow plants of their choices through a simple way. …”
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Using surface markers to describe the kinematics of the medial longitudinal arch in a longitudinal study of flexible flat feet and health-related quality of life by Uhan, J

“…Flexible flat foot (FFF) is a condition which, despite being commonly seen in the clinical setting, has no clear consensus on its aetiology, prognosis, or management plan. This thesis aimed to observe the natural development of the medial longitudinal arch (MLA) from childhood into adulthood in in FFF and compare it with neutral feet (NF). …”

Developing sustainable human macaque communities by Jones-Engel, Lisa, Engel, Gregory, Gumert, Michael David, Fuentes, Agustín

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Six-year removal of co-dominant grasses alleviated competitive pressure on subdominant grasses but dominant shrub removal had neutral effects in a subalpine ecosystem by Li, Wenjin, Knops, Johannes M. H., Png, Kenny Guochen, Yan, Xi, Dong, Huan, Li, Jinhua, Zhou, Huakun, Sierra, Rubén Díaz

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A study on giant panda recognition based on images of a large proportion of captive pandas by Chen, Peng, Swarup, Pranjal, Matkowski, Wojciech Michal, Kong, Adams Wai Kin, Han, Su, Zhang, Zhihe, Rong, Hou

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Colonic mucosal microbiota and association of bacterial taxa with the expression of host antimicrobial peptides in pediatric ulcerative colitis by Jalanka, Jonna, Cheng, Jing, Hiippala, Kaisa, Ritari, Jarmo, Salojärvi, Jarkko, Ruuska, Tarja, Kalliomäki, Marko, Satokari, Reetta

“…Inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), are chronic debilitating disorders of unknown etiology. Over 200 genetic risk loci are associated with IBD, highlighting a key role for immunological and epithelial barrier functions. …”
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A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder by Cataldo, Ilaria, Azhari, Atiqah, Esposito, Gianluca

“…Although these genes did not surface in genome-wide association studies, evidence supports the hypothesis that these receptors and their polymorphisms are widely involved in the regulation of social behavior, and in modulating neural and physiological pathways contributing to the etiology of ASD. With a specific focus on variants considered to be among the most prevalent in the development of ASD, these issues will be discussed in-depth and suggestions to approach inconsistencies in the present literature will be provided. …”
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Root nutrient uptake strategies across forest types in Singapore's Central Catchment Nature Reserve by Poon, Hock Jin

“… • Despite recent advances in our understanding of roots and their processes, tropical belowground ecology remains understudied, especially in Southeast Asia.…”
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Anticipating evolutionary responses of mosquito mating systems to population suppression with mass-reared males by Cator, LJ, Bonsall, MB

“…We provide a mathematical framework for integrating mosquito mating ecology into models of population suppression. Given that these strategies are being increasingly deployed, anticipating and managing evolutionary responses of target population behavior should be a priority for research.…”

Bioconversion of styrene to poly(hydroxyalkanoate) (PHA) by a new bacterial strain Pseudomonas putida NBUS12 by Tan, Giin-Yu Amy, Chen, Chia-Lung, Ge, Liya, Li, Ling, Tan, Swee Ngin, Wang, Jing-Yuan

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Mapping miRNA research in schizophrenia: a scientometric review by Lim, Mengyu, Carollo, Alessandro, Neoh, Michelle Jin Yee, Esposito, Gianluca

“…Micro RNA (miRNA) research has great implications in uncovering the aetiology of neuropsychiatric conditions due to the role of miRNA in brain development and function. …”
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Observations on baboons, Papio anubis, in an arid region in Ethiopia by Aldrich-Blake, FP, Bunn, TK, Dunbar, RI, Headley, PM

“…A population of baboons, <i>Papio anubis</i>, was studied for 3 months in an area of arid thornscrub in Ethiopia. The ecology of the habitat is described. Eight troops were surveyed, and one troop was studied in detail. …”

Vitamin B12 ameliorates the pathological phenotypes of multiple Parkinson’s disease models by alleviating oxidative stress by Wu, Yue, Zhao, Zhongting, Yang, Naidi, Xin, Chenqi, Li, Zheng, Xu, Jiajia, Ma, Bo, Lim, Kah-Leong, Li, Lin, Wu, Qiong, Yu, Changmin, Zhang, Chengwu

“…Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains incurable. …”
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Genetic visualization of cultural heritage: A case study of Zhuxian Town woodblock prints by Liu, Haoran, Alli, Hassan, Md Yusoff, Irwan Syah

“…The key to preserving and developing cultural ecology levels is employing visualization methods and a strategic approach. …”