Effects of doping concentration on bond length and bond energy studied by Raman shift by Yang, Xuexian, Dong, Zhili, Sun, Chang Q.

“…Numerical reproduction of the measurements clarified that the host atom phonons involved interaction with all of its z neighbors, whereas the doping atom phonon only involved interaction with a dimer. …”
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Discovery of glucose-specific, peptide-based carbohydrate mimics using phage displayed random peptide libraries. by Yu, Limin.

“…As part of a larger project to establish general rules for peptide and peptidomimetic-based sugar mimicry, we have screened two phage display libraries (“C-X7-C” and “X12”) against a series of three glucose-binding plant lectins: Concanavalin A (Con A), Pisum Sativum Agglutinin (PSA), and Lens Culinaris Agglutinin (LCA), so as to discover ligands that bind ALL THREE lectins and therefore could act as true functional sugar mimics. …”
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Computational screening of FDA-approved hepatitis c drugs for inhibition of VEGFR2 in liver cancer by Roney, Miah, Issahaku, Abdul Rashid, Tufail, Nasir, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Compared to the control compound, two FDA-approved HCV drugs (DB09102 and DB09027) were selected based on their binding energies and interactions with the target protein, which showed comparable binding energies. …”
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HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease by Yogeshwar, SM, Muñiz-Castrillo, S, Sabater, L, Peris-Sempere, V, Mallajosyula, V, Luo, G, Yan, H, Yu, E, Zhang, J, Lin, L, Fagundes Bueno, F, Ji, X, Picard, G, Rogemond, V, Pinto, AL, Heidbreder, A, Höftberger, R, Graus, F, Dalmau, J, Santamaria, J, Iranzo, A, Schreiner, B, Giannoccaro, MP, Liguori, R, Shimohata, T, Kimura, A, Ono, Y, Binks, S, Mariotto, S, Dinoto, A, Bonello, M, Hartmann, CJ, Tambasco, N, Nigro, P, Prüss, H, McKeon, A, Davis, MM, Irani, SR, Honnorat, J, Gaig, C, Finke, C, Mignot, E

“…The functional relevance of the observed HLA-DQ molecules was studied with competition binding assays. These proof-of-concept experiments revealed preferential binding of IgLON5 in a post-translationally modified, but not native, state to all three risk-associated HLA-DQ receptors. …”

Screening for pathogenic neuronal autoantibodies in serum and CSF of patients with first-episode psychosis by Theorell, J, Ramberger, M, Harrison, R, Mgbachi, V, Jacobson, L, Waters, P, Erhardt, S, Sellgren, CM, Cervenka, S, Piehl, F, Irani, SR

“…These identified 3/71 (4%) patient sera with weak binding to either contactin-associated protein-like 2, the NMDAR or glycine receptor versus no binding from 48 control samples (p = 0.28, Fisher's test). …”

Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum by Song, Yutong, Zhao, Zhihao, Xu, Linyu, Huang, Peiyuan, Gao, Jiayang, Li, Jingxuan, Wang, Xuejie, Zhou, Yiren, Wang, Jinhui, Zhao, Wenting, Wang, Likun, Zheng, Chaogu, Gao, Bo, Jiang, Liwen, Liu, Kai, Guo, Yusong, Yao, Xiaoqiang, Duan, Liting

“…Sustained mechanostimuli increase the levels of binding-immunoglobulin protein (BiP) expression and phosphorylated eIF2α, two markers for ER stress. …”
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Polar curved polycyclic aromatic hydrocarbons in soot formation by Menon, Angiras, Martin, Jacob W., Bowal, Kimberly, Slavchov, Radomir I., Akroyd, Jethro, Mosbach, Sebastian, Kraft, Markus

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Structural insights into polyamine spermidine uptake by the ABC transporter PotD-PotABC by Qiao, Zhu, Do, Phong Hoa, Yeo, Joshua Yi, Ero, Rya, Li, Zhuowen, Zhan, Liying, Basak, Sandip, Gao, Yong-Gui

“…Polyamines, characterized by their polycationic nature, are ubiquitously present in all organisms and play numerous cellular functions. …”
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Investigating molecular vulnerabilities in TP53-mutant transformed myeloproliferative neoplasms by Paterson, A

“…In addition to this intra-patient comparison, analysis included comparisons between <em>TP53</em>-mutant LSC and healthy donor controls and <em>TP53</em>-WT MPN patients. In all comparisons, I identified a cohort of RNA-binding proteins (RBP) to be significantly upregulated in <em>TP53</em>-mutant LSC. …”

Atherogenesis and plaque rupture, surface/interface-related phenomena by Siegel, G., Berkholz, J., Klüßendorf, D., Knosalla, C., Zakrzewicz, A., Ermilov, E., Malmsten, M., Lindman, Bjorn

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Harnessing cooperative multivalency in thioguanine for surface-enhanced raman scattering (SERS)-based differentiation of polyfunctional analytes differing by a single functional gr... by Nguyen, Lam Bang Thanh, Tan, Emily Xi, Leong, Shi Xuan, Koh, Charlynn Sher Lin, Madhumita, Murugan, Phang, In Yee, Ling, Xing Yi

“…Crucially, we demonstrate distinct spectral changes induced by the tridentate interaction between TG's three anchoring points and all the analyte's functional groups, even the least reactive ones. …”
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Salting effects on protein components in aqueous NaCl and urea solutions : toward understanding of urea-induced protein denaturation by Mu, Yuguang, Li, Weifeng, Zhou, Ruhong

“…Our results show that NaCl displays strong capability to salt out all 15 molecules, while urea facilitates the solvation (salting-in) of all the 15 molecules on the other hand. …”
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Investigating factors contributing to enhancer-promoter interaction by Cornell, LJ

“…Enhancer promoter interactions usually occur within topologically associated domains (TADs); large regions (200-2000kb) of interacting chromatin delimited by binding sites for the insulating factor CTCF. Whilst we know that all these mechanisms play a role, it remains unclear how each contributes. …”

Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome by Cho, Nam-Joon, Lee, Choongho, Pang, Phillip S., Pham, Edward A., Fram, Benjamin, Nguyen, Khanh, Xiong, Anming, Sklan, Ella H., Elazar, Menashe, Koytak, Elif S., Kersten, Caroline, Kanazawa, Kay K., Frank, Curtis W., Glenn, Jeffrey S.

“…A pair of positively charged residues within the amphipathic helix (the basic amino acid PI(4,5)P2 pincer domain) was required for PI(4,5)P2 binding and replication of the HCV-RNA genome. A similar motif was found to be conserved across all HCV isolates, as well as amphipathic helices of many pathogens and apolipoproteins. …”
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Formal contracts mitigate social dilemmas in multi-agent reinforcement learning by Haupt, Andreas, Christoffersen, Phillip, Damani, Mehul, Hadfield-Menell, Dylan

“…First, we show that this augmentation makes all subgame-perfect equilibria of all Fully Observable Markov Games exhibit socially optimal behavior, given a sufficiently rich space of contracts. …”
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Parsing and semantic analysis of a domain specific language by Qin, Gemeng

“…In this project, stencil computation in MATLAB is analysed as a case study. Since all data types in MATLAB is in a form of an array, the analysis of arrays were performed in the implementation. …”
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The Mark of Cain: The crime of terrorism in times of armed conflict as interpreted by the Court of Appeal of England and Wales in R v. Mohammed Gul by Coco, A

“…In particular, some international conventions on terrorism binding on the UK establish that all attacks committed in the context of an armed conflict, including non-international armed conflicts, continue to be governed by international humanitarian law (IHL). …”

Development of in-line fiber-optic interferometric sensors by using biopolymer : chitosan. by Chen, Li Han.

“…The anti-IgG detection sensitivity and concentration detection limit are evaluated by Langmuir isotherm parameters and anti-IgG surface density. In all, these sensors can directly detect the binding of analytes to the immobilized antigen/antibodies without using any labelling reagents. …”
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Adhesive properties of adsorbed layers of two recombinant mussel foot proteins with different levels of DOPA and tyrosine by Bilotto, Pierluigi, Labate, Cristina, De Santo, Maria P., Deepankumar, Kanagavel, Miserez, Ali, Zappone, Bruno

“…In one variant, all tyrosine residues were modified into 3,4-dihydroxy-l-phenylalanine (DOPA) during expression using a residue-specific incorporation strategy. …”
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Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake by Kwek, Germain, Lingesh, Shonya, Chowdhury, Sayba Zafrin, Xing, Bengang

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