Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling by Rohatgi, Rajat, Nachtergaele, Sigrid, Whalen, Daniel M, Mydock, Laurel K, Zhao, Zhonghua, Malinauskas, Tomas, Krishnan, Kathiresan, Covey, Douglas F, Siebold, Christian, Ingham, Philip William

“…Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling by all known classes of Hh activators and by clinically relevant Smo mutants.…”
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Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites by Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani

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A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications by Chen, Xiao, Li, Hua, Lam, King-Yeung

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Gender-based multi-aspect sentiment detection using multilabel learning by Kumar, J. Ashok, Trueman, Tina Esther, Cambria, Erik

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Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”

Real‐time imaging of dynamic cell reprogramming with nanosensors by Wiraja, Christian, Yeo, David Chenloong, Tham, Khek-Chian, Chew, Sharon Wan Ting, Lim, Xinhong, Xu, Chenjie

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Membrane reconstitution of monoamine oxidase enzymes on supported lipid bilayers by Wang, Liulin, Kabir H. Biswas, Yoon, Bo Kyeong, Kawakami, Lisa M., Park, Soohyun, Groves, Jay T., Li, Lin, Huang, Wei, Cho, Nam-Joon

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Peptide asparaginyl ligases—renegade peptide bond makers by Tam, James P., Chan, Ning-Yu, Liew, Heng Tai, Tan, Shaun J., Chen, Yu

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Does everyone have the potential to achieve their ideal body weight? Lay theories about body weight and support for price discrimination policies by Li, Kevin Shaobo, Kokkoris, Michail D., Savani, Krishna

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Structure and subunit arrangement of Mycobacterial F1FO ATP synthase and novel features of the unique mycobacterial subunit δ by Kamariah, Neelagandan, Huber, Roland G., Nartey, Wilson, Bhushan, Shashi, Bond, Peter J., Grüber, Gerhard

“…The arrangement of δ relative to the N-termini of the catalytic α3β3-headpiece and its potential as a drug target are discussed.…”
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Polymeric composites for powder-based additive manufacturing : materials and applications by Yuan, Shangqin, Shen, Fei, Chua, Chee Kai, Zhou, Kun

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1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity by Yang, Xuan, Wedajo, Wassihun, Yamada, Yoshiyuki, Dahlroth, Sue-Li, Neo, Jason Jun-Long, Dick, Thomas, Chui, Wai-Keung

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Real-time nanoplasmonic sensing of three-dimensional morphological changes in a supported lipid bilayer and antimicrobial testing applications by Yoon, Bo Kyeong, Park, Hyeonjin, Zhdanov, Vladimir P., Jackman, Joshua A., Cho, Nam-Joon

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Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation by Ma, Enguang, Chen, Kai, Sun, Liang, Fu, Zhinan, Guo, Jiangtao, Liu, Jichang, Zhao, Jigang, Liu, Zhiyong, Lei, Zhigang, Li, Li, Hu, Xiao, Guo, Xuhong

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The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions by Ahmed, Syed Moiz, Ragunathan, Priya, Shin, Joon, Peter, Sabrina, Kleissle, Sabrina, Neuenschwander, Martin, Schäfer, Reinhold, Kries, Jens Peter V., Grüber, Gerhard, Dröge, Peter

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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin by Fu, Afu, Ma, Shijun, Wei, Na, Tan, Blanche Xiao Xuan, Tan, Ern Yu, Luo, Kathy Qian

“…Specific siRNA-mediated MnSOD knockdown reversed all three phenotypes. Our findings therefore suggest that MnSOD plays an important integrative role in supporting cancer cell survival in circulation, metastasis, and doxorubicin resistance. …”
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Integrated analysis of the Plasmodium species transcriptome by Hoo, Regina, Zhu, Lei, Amaladoss, Anburaj, Mok, Sachel, Natalang, Onguma, Lapp, Stacey A., Hu, Guangan, Liew, Kingsley, Galinski, Mary R., Bozdech, Zbynek, Preiser, Peter Rainer

“…However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. …”
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Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…In addition to kinases, we examined the therapeutic potential of the FDA-approved hypertension drug, losartan. Losartan ameliorated the acidic store Ca²⁺ defect, which characterizes NPC, and all downstream pathologies as well as in combination with miglustat reduced levels of neuroinflammation in the mouse model. …”

Evaluating the rediscovery process as a treatment programme for a range of substance use disorders by Parker, Phil

“…No effect on outcomes was seen in the different referral routes for all analysed measures, at all time points, with the exception of impulsivity at 1month and QOL at 3-month. …”
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An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore by Ang, Li Wei, Ng, Oon Tek, Boudville, Irving Charles, Leo, Yee Sin, Wong, Chen Seong

“…The most common metabolic abnormality among PLHIV was HDL hypocholesterolemia (60.2%) followed by hypertriglyceridemia (45.5%). Of all the 2,231 individuals, 68.8% had at least one component of MetS. …”
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