Specific inhibition of PI3K p110δ inhibits CSF‐1‐induced macrophage spreading and invasive capacity by Mouchemore, KA, Sampaio, N, Murrey, MW, Stanley, ER, Lannutti, BJ, Pixley, FJ

“…While primary bone marrow‐derived macrophages and the immortalized bone marrow‐derived macrophage cell line M−/−.WT express all three class IA PI3K isoforms, p110δ predominates in the cell line. …”

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis by Sonesson, Andreas, Przybyszewska, Kornelia, Eriksson, Sigrid, Mörgelin, Matthias, Kjellström, Sven, Davies, Julia, Potempa, Jan, Schmidtchen, Artur

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Synthesis of bioconjugated gold nanoparticles for targeted imaging of breast cancer cells by Low, Yu Qi

“…Dark field images showed binding of gold nanoparticles on cell membranes of SKBR-3 cells while little or no particles were distributed near the HER2 negative MCF-7 cells. …”
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Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…Compound 7 also showed good antiproliferative potency in the NCI-60 cell line panel with a GI50 of 1.34 µM against MDA-MB-231 breast cancer cells. …”

Investigating molecular vulnerabilities in TP53-mutant transformed myeloproliferative neoplasms by Paterson, A

“…Further mechanistic investigation, including identification of PCBP2-binding transcripts and protein-binding partners will help to validate molecular requirements of PCBP2 in <em>TP53</em>-sAML.…”

Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…Finally, we characterized the kinetics of a mild electrophile, the squaric ester, and assessed its utility in selectively binding and modifying a key galactofuranosyl transferase involved in mycobacterial cell wall biosynthesis. …”
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Vypal2: a versatile peptide ligase for precision tailoring of proteins by Zhang, Dingpeng, Wang, Zhen, Hu, Side, Lescar, Julien, Tam, James P., Liu, Chuan-Fa

“…The last two decades have seen an increasing demand for new protein-modification methods from the biotech industry and biomedical research communities. Owing to their mild aqueous reaction conditions, enzymatic methods based on the use of peptide ligases are particularly desirable. …”
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Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm by Ng, Calista Keow Leng, Herath, Wishva, Lili, Sun, Hutchins, Andrew P, Robson, Paul, Kolatkar, Prasanna R, Stanton, Lawrence W, Aksoy, Irene, Jauch, Ralf, Chen, Jiaxuan, Dyla, Mateusz, Divakar, Ushashree, Bogu, Gireesh K, Teo, Roy

“…We show that Sox17 partners with Oct4 and binds to a unique ‘compressed’ Sox/Oct motif that earmarks endodermal genes. …”
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Seroprevalence of SARS-CoV-2 in children and adolescents by Ratcliffe, H

“…</p> <br> <p>The findings of ‘STORY’ confirm that SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalisation. …”

Accumulation, depuration and distribution of cadmium and zinc in the green-lipped mussel Perna viridis (Linnaeus) under laboratory conditions by Yap, C.K., Ismail, A., Tan, S.G., Omar, H.

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Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2 by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.

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Soy-derived phytochemical genistein modifies chromatome topology to restrict cancer cell proliferation by Dutta, Bamaprasad, Park, Jung Eun, Qing, Ivan Toh Yi, Kon, Oi Lian, Sze, Siu Kwan

“…We therefore investigated genistein effects on chromatin-bound proteins in the estrogen receptor-deficient cell line MDA-MB-231 which is insensitive to phytoestrogen signaling. …”
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Cluster-selective 57Fe labeling of a Twitch-domaincontaining radical SAM enzyme by Namkoong, Gil, Suess, Daniel LM

“…This method for cluster-selective isotopic labeling could in principle be applied to any protein that binds multiple Fe–S clusters so long as the clusters undergo exchange with exogenous Fe ions at sufficiently different rates.…”
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Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function by Murali, TM, Gu, Y, Minhat, RA, Yap, J, Wood, KJ, Wang, C, Gascoigne, NRJ, Anantharaman, V, MacAry, PA

“…Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation. …”

Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…By employing Surface Plasmon Resonance (SPR) and Nuclear Magnetic Resonance (NMR), C3 was identified to bind to the co-regulator binding pocket and is a strong candidate to be chemically-linked to L1, in hopes of increasing its potency as well as its binding affinity and specificity to Nurr1. …”
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Opportunity for genome engineering to enhance phosphate homeostasis in crops by Abdullah, Siti Nor Akmar, Ariffin, Norazrin, Md Hatta, Muhammad Asyraf, Kemat, Nurashikin

Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…The NMR spectroscopy titration experiments with branched chain amino acids revealed the specific binding of valine to the MtRel ACT and showed structural rearrangement upon valine binding. …”
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The opioid receptor influences circadian rhythms in human keratinocytes through the β-arrestin pathway by Bigliardi, Paul, Junnarkar, Seetanshu, Markale, Chinmay, Lo, Sydney, Bigliardi, Elena, Kalyuzhny, Alex, Ong, Sheena, Dunn, Ray, Wahli, Walter, Bigliardi-Qi, Mei

“…In this study, we propose a significant association between cutaneous opioid receptor (OPr) activity and circadian rhythmicity. To investigate this link, we conducted a 48 h circadian rhythm experiment, during which RNA samples were collected every 5 h. …”
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Myristoylation restricts orientation of the GRASP domain on membranes and promotes membrane tethering by Heinrich, Frank, Nanda, Hirsh, Goh, Haw Zan, Bachert, Collin, Lösche, Mathias, Linstedt, Adam D.

“…The mammalian Golgi reassembly stacking protein (GRASP) proteins are Golgi-localized homotypic membrane tethers that organize Golgi stacks into a long, contiguous ribbon-like structure. It is unknown how GRASPs undergo trans pairing given that cis interactions between the proteins in the plane of the membrane are intrinsically favored. …”
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Breaking the symmetry : gradient in NiFe layered double hydroxide nanoarrays for efficient oxygen evolution by Zhou, Daojin, Jia, Yin, Duan, Xinxuan, Tang, Jialun, Xu, Jie, Liu, Dong, Xiong, Xuya, Zhang, Junming, Luo, Jun, Zheng, Lirong, Liu, Bin, Kuang, Yun, Sun, Xiaoming, Duan, Xue

“…Breaking the symmetry in catalysts through interface engineering has emerged as a new dimension in enhancing the catalytic performances, while the long-range asymmetry (i.e. in nanometer scale) in catalysts can hardly be achieved by alloying or doping. …”
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