The opioid receptor influences circadian rhythms in human keratinocytes through the β-arrestin pathway by Bigliardi, Paul, Junnarkar, Seetanshu, Markale, Chinmay, Lo, Sydney, Bigliardi, Elena, Kalyuzhny, Alex, Ong, Sheena, Dunn, Ray, Wahli, Walter, Bigliardi-Qi, Mei

“…In this study, we propose a significant association between cutaneous opioid receptor (OPr) activity and circadian rhythmicity. To investigate this link, we conducted a 48 h circadian rhythm experiment, during which RNA samples were collected every 5 h. …”
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Myristoylation restricts orientation of the GRASP domain on membranes and promotes membrane tethering by Heinrich, Frank, Nanda, Hirsh, Goh, Haw Zan, Bachert, Collin, Lösche, Mathias, Linstedt, Adam D.

“…The mammalian Golgi reassembly stacking protein (GRASP) proteins are Golgi-localized homotypic membrane tethers that organize Golgi stacks into a long, contiguous ribbon-like structure. It is unknown how GRASPs undergo trans pairing given that cis interactions between the proteins in the plane of the membrane are intrinsically favored. …”
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Breaking the symmetry : gradient in NiFe layered double hydroxide nanoarrays for efficient oxygen evolution by Zhou, Daojin, Jia, Yin, Duan, Xinxuan, Tang, Jialun, Xu, Jie, Liu, Dong, Xiong, Xuya, Zhang, Junming, Luo, Jun, Zheng, Lirong, Liu, Bin, Kuang, Yun, Sun, Xiaoming, Duan, Xue

“…Breaking the symmetry in catalysts through interface engineering has emerged as a new dimension in enhancing the catalytic performances, while the long-range asymmetry (i.e. in nanometer scale) in catalysts can hardly be achieved by alloying or doping. …”
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Integrated in-memory sensor and computing of artificial vision system based on reversible bonding transition-induced nitrogen-doped carbon quantum dots (N-CQDs) by Yu, Tianqi, Li, Jie, Lei, Wei, Shafe, Suhaidi, Mohtar, Mohd Nazim, Jindapetch, Nattha, van Dommelen, Paphavee, Zhao, Zhiwei

Protein interaction studies of crosslinked endolevanase aggregates from Bacillus lehensis G1 by Makki, Hotaf Hassan, Jaafar, Nardiah Rizwana, A. Rahman, Roshanida, Rahmat, Zaidah, Ni Nyoman Tri Puspaningsih, Ni Nyoman Tri Puspaningsih, Md. Illias, Rosli

“…The efficiency of cross-linked enzyme aggregates (CLEAs) is mainly affected by the strength and binding site of the formed linkages between the enzyme and cross-linker. …”
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Histone lysine and DNA methylation: dynamic marks in the chromatin by Belle, R

“…A common post translational modification is Nε-lysine methylation which is linked to transcriptional silencing or activation depending on the location within the nucleosome. …”

Label-free microfluidic cell sorting and detection for rapid blood analysis by Lu, Nan, Tay, Hui Min, Petchakup, Chayakorn, He, Linwei, Gong, Lingyan, Maw, Kay Khine, Leong, Sheng Yuan, Lok, Wan Wei, Ong, Hong Boon, Guo, Ruya, Li, Holden King Ho, Hou, Han Wei

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High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5 by Liu, Chuan-Fa, Zheng, Jie, Yong, Hui Yee, Panutdaporn, Nantika, Tang, Kai, Luo, Dahai

“…Our work demonstrates that RIG-I binds and responds differently to short triphosphorylated RNA and long duplex RNA and that sequential addition of RNA and ATP triggers specific allosteric effects leading to RIG-I CARDs activation. …”
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Selective lighting up of epiberberine alkaloid fluorescence by fluorophore-switching aptamer and stoichiometric targeting of human telomeric DNA G-quadruplex multimer by Zhang, Lihua, Liu, Hua, Shao, Yong, Lin, Clement, Jia, Huan, Chen, Gang, Yang, Danzhou, Wang, Ying

“…More importantly, EPI, as the brightest FSA emitter among the alkaloids, can also serve as an efficient conformation probe for HTG DNA and discriminate the DNA G-quadruplex from the RNA counterpart. Furthermore, EPI can bind stoichiometrically to each G-quadruplex unit of long HTG DNA multimer with the most significant fluorescence enhancement, which has not been achieved by the previously reported probes. …”
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‘On-demand’ soft tissue adhesives by Mogal, Vishal Tukaram

“…Thus, indicating the tuning of adhesion depending on time of UV irradiation and type of diazirines functionalized on polyester films. The covalent crosslinking of hydroxyethyl methacrylate polymer brushes grafted on quartz surface to wetted tissues were studied following long-range UV light activation. …”
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Membrane-induced tau amyloid fibrils by El Mammeri, Nadia, Gampp, Olivia, Duan, Pu, Hong, Mei

“…Importantly, SUV-bound tau developed long fibrils that exhibit the characteristic β-sheet chemical shifts of Tyr310 in heparin-fibrillized tau. …”
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Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…One of defining features of the cells of the nervous system is their strong polarity. They have long projections that extend to distances that could be thousands of times the length of the cell body. …”

Purification of miraculin from miracle fruit [Synsepalum dulcifium (Schumach. & Thonn.) Daniell] by He, Zuxing

“…Synsepalum dulcificum, is a kind of berries, when eaten causes sour foods subsequently consumed to taste sweet. …”
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A model for cis-regulation of transcriptional condensates and gene expression by proximal lncRNAs by Natarajan, Pradeep, Shrinivas, Krishna, Chakraborty, Arup K

“…Long noncoding RNAs (lncRNAs) perform several important functions in cells including cis-regulation of transcription. …”
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Live-cell imaging and functional dissection of Xist RNA reveal mechanisms of X chromosome inactivation and reactivation by Ha, Norbert How Ong, Lai, Lan-Tian, Chelliah, Rosi, Zhen, Yashu, Seet, Vanessa Pei Yi, Lai, Soak-Kuan, Li, Hoi-Yeung, Ludwig, Alexander, Sandin, Sara, Chen, Lingyi, Zhang, Li-Feng

“…We double-tagged Xist (inactivated X chromosome-specific transcript), a prototype long non-coding RNA pivotal for X chromosome inactivation (XCI), using the programmable RNA sequence binding domain of Pumilio protein, one tag for live-cell imaging and the other replacing A-repeat (a critical domain of Xist) to generate “ΔA mutant” and to tether effector proteins for dissecting Xist functionality. …”
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Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2 by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.

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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Previously, it had been observed that a single high-dose treatment with the iminosugar MON-DNJ led to long-lasting antiviral effects in lethal dengue mouse models via alpha-glucosidase I inhibition. …”

Nonreciprocal phenomena in superconductivity by Davydova, Marharyta

“…Nonreciprocal superconductors describe certain classes of unconventional superconductors that include certain kinds of mixed-pairing and finite-momentum ones. …”
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Outer-membrane permeabilization, LPS transport inhibition: activity, interactions, and structures of thanatin derived antimicrobial peptides by Swaleeha Jaan Abdullah, Yan, Bernice Tan Siu, Palanivelu, Nithya, Dhanabal, Vidhya Bharathi, Bifani, Juan Pablo, Bhattacharjya, Surajit

“…Thanatin, a 21-residue-long insect-derived antimicrobial peptide (AMP), is a promising lead molecule for the potential development of novel antibiotics. …”
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Structure of the C-terminal domain of the multifunctional ICP27 protein from herpes simplex virus 1 by Nordlund, Par, Patel, Vidhi, Dahlroth, Sue-Li, Rajakannan, Venkatachalam, Ho, Hai Ting, Cornvik, Tobias

“…The structure reveals the C-terminal half of ICP27 to have a novel fold consisting of -helices and long loops, along with a unique CHCC-type of zinc-binding motif. …”
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