Discovery of novel triazole-containing pyrazole ester derivatives as potential antibacterial agents by Chu, Ming-Jie, Liu, Hao, Cheng, Xiang, Mo, Kai, Wang, Li, Tang, Feng, Lv, Xian-Hai, Wang, Wei, Ren, Zi-Li

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Elucidating the effect of polyethylene terephthalate chain structure on its enzymatic degradation behavior by Lena, Jean-Baptiste, Gonçalves, Rui A., Kharel, Sharad, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Pinchi, Keerthi Mohan, Lim, Sierin, Lam, Yeng Ming

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Harnessing cooperative multivalency in thioguanine for surface-enhanced raman scattering (SERS)-based differentiation of polyfunctional analytes differing by a single functional gr... by Nguyen, Lam Bang Thanh, Tan, Emily Xi, Leong, Shi Xuan, Koh, Charlynn Sher Lin, Madhumita, Murugan, Phang, In Yee, Ling, Xing Yi

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Age-related bone loss is associated with FGF21 but not IGFBP1 in healthy adults by Lee, Shuen Yee, Fam, Kai Deng, Chia, Kar Ling, Yap, Margaret M. C., Goh, Jorming, Yeo, Kwee Poo, Yap, Eric Peng Huat, Chotirmall, Sanjay Haresh, Lim, Chin Leong

“…The fibroblast growth factor 21 (FGF21)–insulin-like growth factor binding protein 1 (IGFBP1) axis regulates bone loss in animals. …”
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Proteomic network of antibiotic-induced outer membrane vesicles released by extensively drug-resistant Elizabethkingia anophelis by Chiang, Ming-Hsien, Chang, Fang-Ju, Kesavan, Dinesh Kumar, Vasudevan, Aparna, Xu, Huaxi, Lan, Kuo-Lun, Huang, Shu-Wei, Shang, Hung-Sheng, Chuang, Yi-Ping, Yang, Ya-Sung, Chen, Te-Li

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Partial desensitization of MYC2 transcription factor alters the interaction with jasmonate signaling components and affects specialized metabolism by Hou, Xin, Singh, Sanjay Kumar, Werkman, Joshua R., Liu, Yongliang, Yuan, Qinghua, Wu, Xia, Patra, Barunava, Sui, Xueyi, Lyu, Ruiqing, Wang, Bingwu, Liu, Xiaoyu, Li, Yongqing, Ma, Wei, Pattanaik, Sitakanta, Yuan, Ling

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ANRIL promoter DNA methylation : a perinatal marker for later adiposity by Lillycrop, Karen, Murray, Robert, Cheong, Clara, Teh, Ai Ling, Clarke-Harris, Rebecca, Barton, Sheila, Costello, Paula, Garratt, Emma, Cook, Eloise, Titcombe, Philip, Shunmuganathan, Bhuvaneshwari, Liew, Samantha J., Chua, Yong-Cai, Lin, Xinyi, Wu, Yonghui, Burdge, Graham C., Cooper, Cyrus, Inskip, Hazel M., Karnani, Neerja, Hopkins, James C., Childs, Caroline E., Chavez, Carolina Paras, Calder, Philip C., Yap, Fabian, Lee, Yung Seng, Chong, Yap Seng, Melton, Philip E., Beilin, Lawrie, Huang, Rae-Chi, Gluckman, Peter D., Harvey, Nick, Hanson, Mark A., Holbrook, Joanna D., Godfrey, Keith M.

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Enzymatic preparation of diacylglycerols: lipase screening, immobilization, characterization and glycerolysis performance by Xie, Rui, Peng, Xianwu, Lee, Yee-Ying, Xie, Pengkai, Tan, Chin-Ping, Wang, Yong, Zhang, Zhen

“…Backgrounds: Glycerolysis, with its advantages of readily available raw materials, simple operation, and mild reaction conditions, is a primary method for producing diacylglycerol (DAG). …”

Vibrational characteristics of shape memory alloy-embedded 3D woven composite plate by Baitab, Danish Mahmood, Majid, Dayang Laila, Abdullah, Ermira Junita, Hamid, Mohd Faisal Abdul

Surface plasmon resonance (SPR) enhanced biosensors by Zhang, Jinling

“…The point-of care device based on grating Au film for the detection of endotoxin (lipopolysaccharide, LPS) was demonstrated, which displayed excellent portability and good sensitivity. …”
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Anisotropic protein diffusion on nanosurface by Liu, Yang, Song, Xiaohan, Yang, Yanmei, Li, Yong-Qiang, Zhao, Mingwen, Mu, Yuguang, Li, Weifeng

“…On the MBP surface, HP35 migrates mainly along the zigzag direction but can also easily stride over the ridges and grooves along the armchair direction. Moreover, the mild binding strength between α-PC and HP35 does not cause distortion in the protein structure. …”
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The role of toca-1-N-wasp complex in filopodia formation and endocytosis by Bu, Wenyu

“…Toca-1 consists of an F-BAR domain at the N-terminal, an HR1 domain (Cdc42 binding site) in the middle and an SH3 domain (N-WASP binding site) at the C-terminal. …”
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Aptamer-based detection of foot-and-mouth disease virus using single-stranded DNA probe by Nordin, Nor Aina, Soon, Samson, Senawi, Jamaliah B., Jinin, Zurin Azlin M., Arshad, Siti Suri, Abd Rahaman, Yasmin, Azri, Farah Asilah

“…After the recombinant VP2 capsid protein was developed, expressed, and refined, it was applied using enzyme-linked aptamer sorbent assay (ELASA) to determine aptamers’ binding capability. …”

Bifunctional diazirine reagent for covalent dyeing of Kevlar and inert polymer materials by Liu, Richard Y., Luo, Shao-Xiong Lennon, Hirst, Elizabeth S., Doona, Christopher J., Swager, Timothy M.

“…The reagent's structure features a trifluoromethyl diazirine group as a precursor to a carbene that binds the textile surface. On the reagent's other terminus, a benzyl bromide group acts as a site accessible for substitution reactions. …”
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Re-understanding the mechanisms of action of the anti-mycobacterial drug bedaquiline by Sarathy, Jickky Palmae, Gruber, Gerhard, Dick, Thomas

“…In a recently uncovered second direct mechanism, BDQ binds to the enzyme’s ε-subunit to disrupt its ability to link c-ring rotation to ATP synthesis at the α3β3-headpiece. …”
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Effects of doping concentration on bond length and bond energy studied by Raman shift by Yang, Xuexian, Dong, Zhili, Sun, Chang Q.

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NMR structure, dynamics and interactions of the integrin β2 cytoplasmic tail with filamin domain IgFLNa21 by Chatterjee, Deepak, Tan, Suet-Mien, Bhattacharjya, Surajit, Lu, Lewis Zhiping

“…In this study, we performed solution NMR analyses of IgFLNa21 in the presence of integrin β2 CT peptides, and hybrid IgFLNa21, a construct of covalently linked IgFLNa21 and β2 CT. The atomic resolution structure of the hybrid IgFLNa21 demonstrated conserved binding mode with β2 CT. …”
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HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease by Yogeshwar, SM, Muñiz-Castrillo, S, Sabater, L, Peris-Sempere, V, Mallajosyula, V, Luo, G, Yan, H, Yu, E, Zhang, J, Lin, L, Fagundes Bueno, F, Ji, X, Picard, G, Rogemond, V, Pinto, AL, Heidbreder, A, Höftberger, R, Graus, F, Dalmau, J, Santamaria, J, Iranzo, A, Schreiner, B, Giannoccaro, MP, Liguori, R, Shimohata, T, Kimura, A, Ono, Y, Binks, S, Mariotto, S, Dinoto, A, Bonello, M, Hartmann, CJ, Tambasco, N, Nigro, P, Prüss, H, McKeon, A, Davis, MM, Irani, SR, Honnorat, J, Gaig, C, Finke, C, Mignot, E

“…Specifically, we identified a predisposing rank-wise association with <em>HLA-DQA1*01:05∼DQB1*05:01</em>, <em>HLA-DQA1*01:01∼DQB1*05:01</em> and <em>HLA-DQA1*01:04∼DQB1*05:03</em> in 85% of patients. HLA sequences and binding cores for these three DQ heterodimers were similar, unlike those of linked DRB1 alleles, supporting a causal link to HLA-DQ. …”

Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…Finally, we characterized the kinetics of a mild electrophile, the squaric ester, and assessed its utility in selectively binding and modifying a key galactofuranosyl transferase involved in mycobacterial cell wall biosynthesis. …”
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Vypal2: a versatile peptide ligase for precision tailoring of proteins by Zhang, Dingpeng, Wang, Zhen, Hu, Side, Lescar, Julien, Tam, James P., Liu, Chuan-Fa

“…The last two decades have seen an increasing demand for new protein-modification methods from the biotech industry and biomedical research communities. Owing to their mild aqueous reaction conditions, enzymatic methods based on the use of peptide ligases are particularly desirable. …”
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