Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm by Ng, Calista Keow Leng, Herath, Wishva, Lili, Sun, Hutchins, Andrew P, Robson, Paul, Kolatkar, Prasanna R, Stanton, Lawrence W, Aksoy, Irene, Jauch, Ralf, Chen, Jiaxuan, Dyla, Mateusz, Divakar, Ushashree, Bogu, Gireesh K, Teo, Roy

“…We show that Sox17 partners with Oct4 and binds to a unique ‘compressed’ Sox/Oct motif that earmarks endodermal genes. …”
Get full text
Get full text

Seroprevalence of SARS-CoV-2 in children and adolescents by Ratcliffe, H

“…</p> <br> <p>The findings of ‘STORY’ confirm that SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalisation. …”

Experimental Characterization of Iron-Sulfur Cluster Excited States and their Relevance to Electron Transfer Reactions by Skeel, Brighton A.

“…We find additionally that the primary coordination sphere has a strong influence on the topography of these excited state landscapes, in particular that the donor properties of the ligands binding an [Fe₄S₄]¹⁺ cluster determine its ground state valence electron distribution. …”
Get full text
Get full text

Accumulation, depuration and distribution of cadmium and zinc in the green-lipped mussel Perna viridis (Linnaeus) under laboratory conditions by Yap, C.K., Ismail, A., Tan, S.G., Omar, H.

Get full text

Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…By employing Surface Plasmon Resonance (SPR) and Nuclear Magnetic Resonance (NMR), C3 was identified to bind to the co-regulator binding pocket and is a strong candidate to be chemically-linked to L1, in hopes of increasing its potency as well as its binding affinity and specificity to Nurr1. …”
Get full text

Opportunity for genome engineering to enhance phosphate homeostasis in crops by Abdullah, Siti Nor Akmar, Ariffin, Norazrin, Md Hatta, Muhammad Asyraf, Kemat, Nurashikin

The opioid receptor influences circadian rhythms in human keratinocytes through the β-arrestin pathway by Bigliardi, Paul, Junnarkar, Seetanshu, Markale, Chinmay, Lo, Sydney, Bigliardi, Elena, Kalyuzhny, Alex, Ong, Sheena, Dunn, Ray, Wahli, Walter, Bigliardi-Qi, Mei

“…In this study, we propose a significant association between cutaneous opioid receptor (OPr) activity and circadian rhythmicity. To investigate this link, we conducted a 48 h circadian rhythm experiment, during which RNA samples were collected every 5 h. …”
Get full text

Integrated in-memory sensor and computing of artificial vision system based on reversible bonding transition-induced nitrogen-doped carbon quantum dots (N-CQDs) by Yu, Tianqi, Li, Jie, Lei, Wei, Shafe, Suhaidi, Mohtar, Mohd Nazim, Jindapetch, Nattha, van Dommelen, Paphavee, Zhao, Zhiwei

Protein interaction studies of crosslinked endolevanase aggregates from Bacillus lehensis G1 by Makki, Hotaf Hassan, Jaafar, Nardiah Rizwana, A. Rahman, Roshanida, Rahmat, Zaidah, Ni Nyoman Tri Puspaningsih, Ni Nyoman Tri Puspaningsih, Md. Illias, Rosli

“…The efficiency of cross-linked enzyme aggregates (CLEAs) is mainly affected by the strength and binding site of the formed linkages between the enzyme and cross-linker. …”
Get full text

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie

Get full text

Histone lysine and DNA methylation: dynamic marks in the chromatin by Belle, R

“…A common post translational modification is Nε-lysine methylation which is linked to transcriptional silencing or activation depending on the location within the nucleosome. …”

Expanding heme-protein folding space using designed multi-heme β-sheet mini-proteins by D’Souza, Areetha, Torres, Jaume, Bhattacharjya, Surajit

Get full text
Get full text

Biomolecular hydration in protein-protein interaction, protein stability and aggregation and lead optimization : computational studies by Mohan Rajan Pradhan

“…After providing a brief overview of biomolecular hydration and outlining the need for new insights to explain experimental observations such as aggregation (Chapter 1), a hydration metric is identified that is linked to Aggregation Prone Regions (APRs) in proteins. …”
Get full text

Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain by Platt, MA

“…</p> <br> <p>The PDCs showed low nanomolar^® IC₅₀ values for displacement of a TRIM24 PHD- and BRD-binding peptide (H3K9Me₃K18Ac), and exhibited avidity for TRIM24, which arises from simultaneous in <em>cis</em> binding to the PHD and BRD. …”

Synthetic post-translational protein modification as a switch for activity by Faulkner, SC

“…Dha chemistry was once again employed to install O- and N-linked GlcNAc mimics in the complement determining region (CDR) of a nanobody cAbLys3, with the aim of reversibly blocking its antigen binding capacity. …”

Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase by Attwood, M

“…However, it was not known whether these functions are conserved in mammalian cells or if they are linked.</p> <p>To inform on OGFOD1-dependent cellular phenotypes, OGFOD1 defective cells were generated by genome editing using the CRISPR methodology. …”

Layer-by-Layer Nanoparticles for Cytokine Delivery by Pires, Ivan S.

“…We also find that the LbL film conformation is key to maintaining therapeutic efficacy as thicker films hinder IL-12 delivery. …”
Get full text

Core level shift of diamond and graphite upon Ar+ ion bombardment by Geng, Han He.

“…Diamond-like films (DLF) and highly oriented pyrolytic graphite (HOPG) are made of two allotropes of carbon, diamond and graphite. …”
Get full text

Three-component Friedel-Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(iii) electrophile by Kikuchi, Jun, Nagata, Toya, Ito, Shingo, Yoshikai, Naohiko

Get full text

Observation of E-cadherin adherens junction dynamics with metal-induced energy transfer imaging and spectroscopy by Chen, T, Karedla, N, Enderlein, J

“…This knowledge enhances our comprehension of tissue and organ development and may serve as a foundation for the development of innovative therapeutic strategies for diseases linked to cell-cell adhesion abnormalities.…”