Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Iminosugars, which inhibit N-linked glycan processing enzymes such as endoplasmic reticulum alpha-glucosidase I and II of the glycoprotein quality control pathway, constituted one of the two most promising groups of drugs in this antiviral cellular screen that have not entered clinical trials yet.…”

Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana by Brooks, Rhiannon L., Mistry, Chandni S., Dixon, Ann M.

“…This may facilitate functional flexibility as previous studies have linked these isoforms not only to ER remodeling but other cellular activities.…”
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Molecular determinants of chromatin accessibility at CpG islands in mouse embryonic stem cells by King, H

“…To examine potential mechanisms by which hypomethylated DNA could serve to promote chromatin accessibility, I profiled chromatin accessibility in mouse ESCs lacking various chromatin-modifying proteins which are normally enriched at CGIs, with the histone demethylases KDM2A/B linked to maintaining open chromatin at CGIs. As an alternative approach to understanding the causes of chromatin accessibility in mouse ESCs, I examined the mechanism by which the pioneer transcription factor OCT4 is able to access previously inaccessible chromatin, and reveal that it requires the chromatin remodeller BRG1 to remodel chromatin and facilitate transcription factor binding at distal regulatory elements. …”

‘On-demand’ soft tissue adhesives by Mogal, Vishal Tukaram

“…Various plasma parameters were investigated for controlling model drug release and soft-tissue adhesion of polyester thin films. When compared to non-treated polyester thin films, plasma intensity could give rise to a ~ 6-fold (for 100 W, 5 min.) increase in shear adhesion strength (157 ± 24 mN/cm2). …”
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Influence of post-deposition annealing on interfacial properties between GaN and ZrO2 grown by atomic layer deposition by Ye, Gang, Wang, Hong, Ng, Serene Lay Geok, Ji, Rong, Arulkumaran, Subramaniam, Ng, Geok Ing, Li, Yang, Liu, Zhi Hong, Ang, Kian Siong

“…Influence of post-deposition annealing on interfacial properties related to the formation/annihilation of interfacial GaOx layer of ZrO2 grown by atomic layer deposition (ALD) on GaN is studied. ZrO2 films were annealed in N2 atmospheres in temperature range of 300 °C to 700 °C and analyzed by X-ray photoelectron spectroscopy and high-resolution transmission electron microscopy. …”
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Engineering modular platforms for rapid vaccine development by Brune, K

“…I demonstrate the modularity of this approach by covalently linking several complex, cysteine-rich malarial antigens to SpyCatcher-VLPs, such as the transmission-blocking antigen Pfs25 and the blood-stage antigen CIDR. …”

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…The MS2-MCP system is used to insert into mRNAs of interest special structures to which RNA-binding proteins, fused to a fluorescent protein such as GFP, can then bind. …”

Integrative imaging and electron cryo-tomography of viral transport mechanisms by Grange, M

“…I apply electron cryo-microscopy and fluorescence microscopy to elucidate the basis for this process, and link this to the behaviour of adenoviruses as they are recruited to microtubules. …”

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Davey, Curt Alexander, Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J.

“…Using a novel ‘atom-to-cell’ approach, we establish the basis for the surprisingly site-selective adduct formation behaviour and distinct cellular impact of these two chemically similar anticancer agents, which suggests that the cytotoxic effects arise largely from DNA lesions, whereas the protein adducts may be linked to the other therapeutic activities. Our study shows promise for developing new ruthenium drugs, via ligand-based modulation of DNA versus protein binding and thus cytotoxic potential, to target distinguishing epigenetic features of cancer cells.…”
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Synthesis, modification and application of fish skin gelatin-based hydrogel as sustainable and versatile bioresource of antidiabetic peptide by Munawaroh, Heli Siti Halimatul, Pratiwi, Riska Nur, Gumilar, Gun Gun, Aisyah, Siti, Rohilah, Siti, Nurjanah, Anisa, Ningrum, Andriati, Susanto, Eko, Pratiwi, Amelinda, Arindita, Ni Putu Yunika, Martha, Larasati, Chew, Kit Wayne, Show, Pau-Loke

“…Antidiabetic bioactivity in vitro and in silico tests showed that the active peptides of SG and TG showed a high binding affinity to α-glucosidase enzyme. In conclusion, SG and TG cross-linked GA 0.05 % have the potential as an antidiabetic agent and as a useful option over mammalian-derived gelatin.…”
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Gene expression regulation by well-known non-coding RNAs by Tan, Jiazi

“…In this thesis, I studied the functions of two well-known non-coding ribonucleic acids (ncRNAs), namely U1 small nuclear ribonucleic acid (snRNA) and Xist, which exert their influence over gene expression via different pathways. 5’ splice site (5’ss) recognition by U1 snRNA binding is one of the first steps in pre-mRNA splicing, which is critical for gene expression in eukaryotes. …”
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Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth by Pollock, K, Cheeseman, H, McFarlane, L, Day, S, Tolazzi, M, Turner, H, Joypooranachandran, J, Shramko, K, Dispinseri, S, Mundsperger, P, Bontjer, I, Lemm, N-M, Coelho, S, Tanaka, M, Cole, T, Korber, B, Katinger, D, Ward, A, Scarlatti, G, Sanders, R, Sattentau, Q, Shattock, R

“…Neutralising antibody function correlated with binding to V1/V3 and V5 epitopes and peaked after the third injection.…”

Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections by Kam, Yiu-Wing, Lee, Cheryl Yi-Pin, Teo, Teck-Hui, Howland, Shanshan W., Siti Naqiah Amrun, Lum, Fok-Moon, See, Peter, Kng, Nicholas Qing-Rong, Huber, Roland G., Xu, Mei-Hui, Tan, Heng-Liang, Choo, Andre, Maurer-Stroh, Sebastian, Ginhoux, Florent, Fink, Katja, Wang, Cheng-I, Ng, Lisa F.P., Rénia, Laurent

“…Zika virus (ZIKV) infections have been linked with neurological complications and congenital Zika syndrome. …”
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Controlling the assembly of proteins and cells on SiO₂ surfaces by Seong, Jiehyun, 1973-

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Unveiling the chirality of the quantum anomalous Hall effect by Chen, Hongyu, Jin, Yuanjun, Mohammad Yahyavi, Belopolski, Ilya, Shao, Sen, Hou, Tao, Wang, Naizhou, Hsu, Chia-Hsiu, Zhao, Yilin, Yang, Bo, Ma, Qiong, Yin, Jia-Xin, Xu, Su-Yang, Gao, Weibo, Chang, Guoqing

“…Here, for the electronic structures of intrinsic QAHE systems, we show that the local Berry curvature is linked with the angular-momentum difference lδz of the inverted bands. …”
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Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis by Sonesson, Andreas, Przybyszewska, Kornelia, Eriksson, Sigrid, Mörgelin, Matthias, Kjellström, Sven, Davies, Julia, Potempa, Jan, Schmidtchen, Artur

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A materials science framework for connecting protein stability with surface adsorption and coating applications by Ma, Gamaliel Junren

“…Although a protein’s conformational stability has been closely linked to its extent of unfolding in the adsorbed state, it remains to be understood how this relationship may be exploited in order to control a protein’s adsorption behavior and adlayer properties to suit specific application needs. …”
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Electrochemical DNA biosensor based on nanoporous alumina membrane by Deng, Jiajia

“…Probe DNA sequences were covalently attached within the pores of the nanoporous alumina membrane using glutaraldehyde cross linking. Binding of target DNA to the probe inside nanopores caused impedance changes due to blocking of nanopores, which provided the sensing signals. …”
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Investigating the role of CDK1 in governing the transcriptional landscape in cancer cells by Pluta, AJ

“…Considering the need for temporal coordination of the cell cycle and the transcription cycle, it can be speculated that the CDKs might play a critical role in linking the two processes. Cyclin-dependent kinase 1 (CDK1) is a highly conserved essential regulator of mitosis, with recognised transcriptional functions revolving around the mitotic repression of gene expression. …”

A hand-targeted auxiliary personal protective equipment for intervention of fomite transmission of viruses by Tan, Justin Kok Soon, Song, Shang Wei, Zeng, Jialiu, Lo, Chih Hung

“…Importantly, FlexiPalm was found to bind significantly less viral protein and VLP than artificial human skin, confirming its ability to reduce viral contamination. …”
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