Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome by Cho, Nam-Joon, Lee, Choongho, Pang, Phillip S., Pham, Edward A., Fram, Benjamin, Nguyen, Khanh, Xiong, Anming, Sklan, Ella H., Elazar, Menashe, Koytak, Elif S., Kersten, Caroline, Kanazawa, Kay K., Frank, Curtis W., Glenn, Jeffrey S.

“…A pair of positively charged residues within the amphipathic helix (the basic amino acid PI(4,5)P2 pincer domain) was required for PI(4,5)P2 binding and replication of the HCV-RNA genome. A similar motif was found to be conserved across all HCV isolates, as well as amphipathic helices of many pathogens and apolipoproteins. …”
Get full text
Get full text

Formal contracts mitigate social dilemmas in multi-agent reinforcement learning by Haupt, Andreas, Christoffersen, Phillip, Damani, Mehul, Hadfield-Menell, Dylan

“…First, we show that this augmentation makes all subgame-perfect equilibria of all Fully Observable Markov Games exhibit socially optimal behavior, given a sufficiently rich space of contracts. …”
Get full text

Parsing and semantic analysis of a domain specific language by Qin, Gemeng

“…In this project, stencil computation in MATLAB is analysed as a case study. Since all data types in MATLAB is in a form of an array, the analysis of arrays were performed in the implementation. …”
Get full text

The Mark of Cain: The crime of terrorism in times of armed conflict as interpreted by the Court of Appeal of England and Wales in R v. Mohammed Gul by Coco, A

“…In particular, some international conventions on terrorism binding on the UK establish that all attacks committed in the context of an armed conflict, including non-international armed conflicts, continue to be governed by international humanitarian law (IHL). …”

Development of in-line fiber-optic interferometric sensors by using biopolymer : chitosan. by Chen, Li Han.

“…The anti-IgG detection sensitivity and concentration detection limit are evaluated by Langmuir isotherm parameters and anti-IgG surface density. In all, these sensors can directly detect the binding of analytes to the immobilized antigen/antibodies without using any labelling reagents. …”
Get full text

Adhesive properties of adsorbed layers of two recombinant mussel foot proteins with different levels of DOPA and tyrosine by Bilotto, Pierluigi, Labate, Cristina, De Santo, Maria P., Deepankumar, Kanagavel, Miserez, Ali, Zappone, Bruno

“…In one variant, all tyrosine residues were modified into 3,4-dihydroxy-l-phenylalanine (DOPA) during expression using a residue-specific incorporation strategy. …”
Get full text

Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake by Kwek, Germain, Lingesh, Shonya, Chowdhury, Sayba Zafrin, Xing, Bengang

Get full text

Solution X-ray scattering studies on the dengue virus non-structural protein 5 and -3 as well as the capsid protein by Saw, Wuan Geok

“…SAXS revealed that NS5 from all four serotypes adopt an extended and a slightly flexible conformation in solution, with DENV-4 NS5 being slightly more compact and less flexible than the other three serotypes. …”
Get full text

Partial desensitization of MYC2 transcription factor alters the interaction with jasmonate signaling components and affects specialized metabolism by Hou, Xin, Singh, Sanjay Kumar, Werkman, Joshua R., Liu, Yongliang, Yuan, Qinghua, Wu, Xia, Patra, Barunava, Sui, Xueyi, Lyu, Ruiqing, Wang, Bingwu, Liu, Xiaoyu, Li, Yongqing, Ma, Wei, Pattanaik, Sitakanta, Yuan, Ling

“…Using tobacco as a model, we generated all possible substitutions of aspartic acid 128 (D128) in NtMYC2a. …”
Get full text

Integrated transcriptomic and proteomic profiling of responses to clinical and novel bisphosphonates by Lu, J

“…Clinical trials have revealed unexpected reductions in risk of multiple ageing related disease and all-cause mortality among osteoporotic patients treated with bisphosphonates. …”

Effect of post-deposition annealing on the interface electronic structures of Al2O3-Capped GaN and GaN/AlGaN/GaN heterostructure by Duan, Tian Li, Pan, Ji Sheng, Ang, Diing Shenp

“…The XPS data, however, reveal a clear Ga-O signal for all samples and no apparent change in the Ga-O to Ga-N bond ratio for the range of annealing temperatures studied. …”
Get full text
Get full text

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…The MS2-MCP system is used to insert into mRNAs of interest special structures to which RNA-binding proteins, fused to a fluorescent protein such as GFP, can then bind. …”

Anisotropic protein diffusion on nanosurface by Liu, Yang, Song, Xiaohan, Yang, Yanmei, Li, Yong-Qiang, Zhao, Mingwen, Mu, Yuguang, Li, Weifeng

Get full text

Investigation on visible light photoresponse of cuprous oxide and zinc oxide heterojunctions on carbon nanotube by Chay, Junwei

“…The results in this reports show that the coating of ZnO and Cu2O did improve the performance of the CNTs samples and all samples are able to response to the visible light.…”
Get full text

Specific inhibition of PI3K p110δ inhibits CSF‐1‐induced macrophage spreading and invasive capacity by Mouchemore, KA, Sampaio, N, Murrey, MW, Stanley, ER, Lannutti, BJ, Pixley, FJ

“…While primary bone marrow‐derived macrophages and the immortalized bone marrow‐derived macrophage cell line M−/−.WT express all three class IA PI3K isoforms, p110δ predominates in the cell line. …”

Predicting rifampicin resistance in M. tuberculosis using machine learning informed by protein structural and chemical features by Lynch, C, Adlard, D, Fowler, P

“…</p> <br> <p><strong>Results:</strong> All four models behaved similarly with sensitivities and specificities in and 0.94-0.97 although we preferred the ensemble of Decision Tree models as inspect and understand. …”

Exploring proteins within the coccolith matrix by Dedman, CJ, Chauhan, N, González-Lanchas, A, Baldreki, C, Dowle, AA, Larson, TR, Lee, RBY, Rickaby, REM

“…Building consensus with existing work, we highlight the pentapeptide repeat as a feature which is associated with the coccolith matrix, being identified in all three examined species, and propose that this structural motif may play a role in controlling coccolith growth. …”

Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling by Rohatgi, Rajat, Nachtergaele, Sigrid, Whalen, Daniel M, Mydock, Laurel K, Zhao, Zhonghua, Malinauskas, Tomas, Krishnan, Kathiresan, Covey, Douglas F, Siebold, Christian, Ingham, Philip William

“…The oxysterol-binding groove in the Smo CRD is analogous to that used by Frizzled 8 to bind to the palmitoleyl group of Wnt ligands and to similar pockets used by other Frizzled-like CRDs to bind hydrophobic ligands. …”
Get full text
Get full text

Separation of acetylene from carbon dioxide and ethylene by a water-stable microporous metal – organic framework with aligned imidazolium groups inside the channels by Lee, Jaechul, Chuah, Chong Yang, Kim, Jaheon, Kim, Youngsuk, Ko, Nakeun, Seo, Younggyu, Kim, Kimoon, Bae, Tae Hyun, Lee, Eunsung

Get full text

Surface modulation of hierarchical MoS2 nanosheets by Ni single atoms for enhanced electrocatalytic hydrogen evolution by Zhang, Huabin, Yu, Le, Chen, Tao, Zhou, Wei, Lou, David Xiong Wen

Get full text