Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie

“…Here we present structural and biochemical evidence that full-length rat NLRP1 (rNLRP1) and rat DPP9 (rDPP9) form a 2:1 complex that contains an autoinhibited rNLRP1 molecule and an active UPA-CARD fragment of rNLRP1. …”
Get full text

Space weather radiation effects on geostationary satellite solid-state power amplifiers by Lohmeyer, W. Q., Cahoy, K. L.

“…By contrast, a Monte Carlo simulation finds that on average, only 2.8 out of 21 (13%) of randomly assigned anomalies occur between 7 and 14days after an electron flux greater than 1.5 standard deviations above the mean. …”
Get full text

Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…This combination was the only non-genotoxic conditioning approach that enabled robust donor engraftment post HSCT in WT mice. Conclusion These findings shed new insights into the mechanism of αCD117 mAb-mediated HSC depletion. …”
Get full text

Boon or bane? : The role of filial piety, relationship quality, caregiver gender on work-family interface among working caregivers of the elderly by Leong, Anthony Xueheng

“…Finally, gender was considered in a three-way interaction between PO and work-family interface in predicting caregiver wellbeing (vitality). Full-time workers who take care of an older relative were recruited; 195 participants (143 women, 52 men) were recruited. …”
Get full text

Sexual violence at higher education institutions: prevalence, nature, and opportunities for prevention by Steele, B

“…This survey was administered to all full-time registered students in 2021. Using the OUR SPACE data, I estimated the past-year prevalence of SV at the University of Oxford disaggregated by type of SV, gender identity, sexual orientation, and ethnicity. …”

Constrained neuro fuzzy inference methodology for explainable personalised modelling with applications on gene expression data by Singh, Balkaran, Doborjeh, Maryam, Doborjeh, Zohreh, Budhraja, Sugam, Tan, Samuel, Sumich, Alexander, Goh, Wilson, Lee, Jimmy, Lai, Edmund, Kasabov, Nikola

“…Interpretable models can potentially support early diagnosis before full disease manifestation. This is particularly important yet, challenging for mental health. …”
Get full text

发达地区失地老人养老支持体系内卷化及其突破 — 基于苏州市的个案研究 = The involution of the eldercare system for the landless elderly in China’s developed regions : a case study based on Suzhou municipality... by 叶继红 Ye Jihong, 占少华 Zhan Shaohua

“…This article, based on an analysis of a “rural to residential”community in Suzhou Municipality, Jiangsu Province, finds that land acquisition has generated a strong impact on the life and pension style of the landless elderly. …”
Get full text

Active learning with applications in biomedical document annotation by Han, Xu

“…The proposed active learning method is a promising research direc- tion and we will conduct further research to exploit the full potential of this method.…”
Get full text

Control and operation of modular multilevel converters by Yang, Shunfeng

“…All the theoretical findings are verified in PLECS simulations. The effectiveness and practicalities of the control algorithms are confirmed on a scale down single-phase MMC prototype.…”
Get full text

Intelligent Solutions for Sustainable Power Grids / by Kumar, L. Ashok, editor 623258, Angalaeswari, S., 1981-, editor 655486, K., Mohanasundaram, 1977-, editor 655487, Bansal, Ramesh C., editor 655488, Patil, Arunkumar, 1985-, editor 655489, IGI Global (Online service) 631983

Get full text

Compositionally graded alloys fabricated using the laser powder bed fusion technique by Wei, Siyuan

“….% Ni was proved to be the lower threshold for fabricating nearly full-density Cu-Ni binary alloy. Cu-7.6Ni-3Al (wt.%) was further designed and fabricated. …”
Get full text

Immunogenicity and safety of beta variant COVID-19 vaccine AZD2816 and AZD1222 (ChAdOx1 nCoV-19) as primary-series vaccination for previously unvaccinated adults in Brazil, South A... by Costa Clemens, SA, Jepson, B, Bhorat, QE, Ahmad, A, Akhund, T, Aley, PK, Bansal, H, Bibi, S, Kelly, EJ, Khan, M, Lambe, T, Lombaard, JJ, Matthews, S, Pipolo Milan, E, Olsson, U, Ramasamy, MN, Moura de Oliveira Paiva, MS, Seegobin, S, Shoemaker, K, Szylak, A, Villafana, T, Pollard, AJ, Green, JA

“…<p><b>Background</b></p> AZD2816 is a variant-adapted COVID-19 vaccine that expresses the full-length SARS-CoV-2 beta variant spike protein but is otherwise similar to AZD1222 (ChAdOx1 nCoV-19). …”

Energy-efficient hardware accelerators based on bit-serial graph and memory-centric computing architectures by Mu, Junjie

“…With the motivation of the lack of reconfigurability and scalability of the existing PDE hardware solvers, we propose the first single chip to solve 2D and 3D PDEs using a full-digital, graph-based architecture in Chapter 5. …”
Get full text

Stability improvement and control optimization of isolated two-stage AC-DC-DC converter systems by Feng, Fan

“…To analyze the stability of the DAB-based two-stage AC-DC-DC converter, the full-order impedance model of the DAB converter is derived for the first time in this thesis. …”
Get full text

Towards electrically injected colloidal semiconductor lasers by Thung, Yi Tian

“…Their advantages of excellent solution processability, large absorption cross-sections, narrow full-width-half-maximum, flexible wavelength tunability, and reduced Auger effects make them promising gain media for next-generation lasing. …”
Get full text

Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial by Silk, SE, Kalinga, WF, Salkeld, J, Mtaka, IM, Ahmed, S, Milando, F, Diouf, A, Bundi, CK, Balige, N, Hassan, O, Mkindi, CG, Rwezaula, S, Athumani, T, Mswata, S, Lilolime, NS, Simon, B, Msami, H, Mohamed, M, David, DM, Mohammed, L, Nyaulingo, G, Mwalimu, B, Juma, O, Mwamlima, TG, Sasamalo, IA, Mkumbange, RP, Kamage, JJ, Barrett, JR, King, LDW, Hou, MM, Pulido, D, Carnrot, C, Lawrie, AM, Cowan, RE, Nugent, FL, Roberts, R, Cho, J-S, Long, CA, Nielsen, CM, Miura, K, Draper, SJ, Olotu, AI, Minassian, AM

“…</p> <br> <p><strong>Findings:</strong> Between Jan 25, 2021, and April 15, 2021, we recruited 12 adults (six [50%] in the Adults 10M group and six [50%] in the Adults DFx group) and 48 children (12 each in the Children 10M, Children 10D, Children DFx, and High Children DFx groups). 57 (95%) of 60 participants completed the vaccination series and 55 (92%) completed 22 months of follow-up following the third vaccination. …”

Evaluation of diabetic wound healing properties of moringa oleifera lam using in vitro and in vivo wound models by Muhammad Amali, Abubakar

“…The in vivo study involved topical application of the formulated bioactive fraction using full thickness excision wound model in streptozotocin (STZ) and nicotinamide (NAD) induced diabetic rats. …”
Get full text

Energy storage management for renewable energy systems by Feng, Xue

“…The research methods and findings are transferable to other renewable sources based on the common feature of intermittency. …”
Get full text

Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021 by Vollset, SE, Ababneh, HS, Abate, YH, Lacey, BWH, GBD 2021 Forecasting Collaborators

“…&lt;h4&gt;Methods&lt;/h4&gt;Using forecasts of major drivers of health such as the Socio-demographic Index (SDI; a composite measure of lag-distributed income per capita, mean years of education, and total fertility under 25 years of age) and the full set of risk factor exposures captured by GBD, we provide cause-specific forecasts of mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) by age and sex from 2022 to 2050 for 204 countries and territories, 21 GBD regions, seven super-regions, and the world. …”

Radar-guided robot by Wang, Jiajun

“…Besides, the radar technology is wildly used nowadays. As an efficient method to detect object, the radar system can use radio frequency signals to detect the surrounding targets even in low-visibility environment. …”
Get full text