A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen

“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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Identification of potential common cyclic-di-GMP regulated biomarkers among three gram negative bacteria via transcriptomic and metabolomic profiling by Cai, Zhao

“…Biofilm infections can evade host immune attack and develop into chronic conditions, which cannot be efficiently eradicated by conventional antimicrobial treatments. In most Gram-negative bacteria, biofilm formation can be regulated by a secondary messenger, bis-(3'-5')-cyclic dimeric guanosine monophos-phate, c-di-GMP. …”
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Evaluating vision-language models long-chain reasoning ability with multiple ground truths by Setiadharma, Christopher Arif

“…With the recent advancements in vision-language models, many researchers start to evaluate their various zero-shot capabilities to answer questions given a video input. …”
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Antibacterial activity of green silver nanoparticles on the in vitro pathogen infected Eucalyptus pellita plant by Sawalha, Hanadi, Ahmad, Siti Aqlima, Shaharuddin, Noor Azmi, Sanusi, Ruzana, Azzeme, Azzreena Mohamad, Naganthran, Ashwini, De Silva, Catrenar, Abiri, Rambod

“…The focal point of the current research is to use of green synthesised AgNPs as an efficient antibacterial agent that particularly targets in vitro pathogen infections in E. pellita plants. Thus, this study finds that green AgNPs possess potent antibacterial activity and could therefore be developed as a promising antimicrobial agent for the treatment of bacterial infections, including gram-positive and gram-negative bacteria.…”

The Robust Malware Detection Challenge and Greedy Random Accelerated Multi-Bit Search by Verwer, Sicco, Nadeem, Azqa, Hammerschmidt, Christian, Bliek, Laurens, Al-Dujaili, Abdullah, O'Reilly, Una-May

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Comparative analysis of dehydration techniques on phytochemical and antibacterial properties on pink and purple flowers impatiens walleriana by Tan, Suat Hian, Sin, Phin Yin, Ros Azlinawati, Ramli, Mohd Hairul, Ab. Rahim, Nyuk, Ling Ma

“…Microwave-dried leaf extracts were evaluated for antibacterial activity using the disc diffusion method. Both pink and purple flower varieties demonstrated inhibition of Gram-positive and Gram-negative bacteria, with the pink flower showing greater antibacterial effects. …”
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Cationic polymer-based antimicrobial and multifunctional hydrogels for enhanced healing of infected wounds by Po, Javier Jun Fai

“…Further improvements such as using a stronger UV photoinitiator can aim to increase the efficacy of PIM-Dex hydrogels to Gram-negative bacteria. In the future, in vivo studies on mouse can be conducted on these antimicrobial hydrogels to better understand its efficacy on human skin.…”
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Designer broad-spectrum polyimidazolium antibiotics by Zhong, Wenbin, Shi, Zhenyu, Mahadevegowda, Surendra H., Liu, Bo, Zhang, Kaixi, Koh, Chong Hui, Ruan, Lin, Chen, Yahua, Zeden, Merve S., Pee, Carmen J. E., Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Zhu, Yabin, Chi, Robin Yonggui, Hammond, Paula T., Yang, Liang, Gan, Yunn-Hwen, Pethe, Kevin, Greenberg, E. Peter, Gründling, Angelika, Chan-Park, Mary B.

“…We synthesized several cationic peptide mimics, main-chain cationic polyimidazoliums (PIMs), and discovered that, although select PIMs show little acute mammalian cell toxicity, they are potent broad-spectrum antibiotics with activity against even pan-antibiotic-resistant gram-positive and gram-negative bacteria, and mycobacteria. …”
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Micropropagation and determination of essential oil components and antimicrobial activities of temu hitam (Curcuma aeruginosa roxb.) by Abdul Aziz, Julia

“…All the four extracted oils appeared to be inactive on Gram negative bacteria Serratia marcescens. From this study, the successful in vitro propagation of C.aeruginosa could provide large scale production of disease-free planting materials. …”
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White-light-responsive prussian blue nanophotonic particles for effective eradication of bacteria and improved healing of infected cutaneous wounds by Chakraborty, Nayanika, Jha, Diksha, Singh, Vijay Pal, Kumar, Pradeep, Verma, Navin Kumar, Gautam, Hemant Kumar, Roy, Indrajit

“…With excellent photothermal and photodynamic properties, CHPB-FD nanoparticles can effectively eradicate both Gram-positive methicillin-resistant Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa in vitro and in vivo. …”
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Ultrasonic-assisted extraction of phenolic compound from harumanis mango leaves (Mangifera indica) using green Natural Deep Eutectic Solvents (NADESs) by Ahmad Mukhlis Abdul Rahman, Ryan Vitthaya Peron, Amirul Ridzuan Abu Bakar, Muhammad Syaffiq Syazwan Jaafar, Qian, Yee Ang, Mohd Asraf Mohd Zainudin, Nik Muhammad Azhar Nik Daud, Ahmad Anas Nagoor Gunny, Nurul Husna Khairuddin

“…Harumanis extract using NADES-3 had saponins, phenols, glycosides, tannins, and antimicrobial activity on gram-positive and gram-negative bacteria. The results show that NADES effectively extracts phenolic compounds from Harumanis leaves, which have significant therapeutic potential.…”
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Proteomic network of antibiotic-induced outer membrane vesicles released by extensively drug-resistant Elizabethkingia anophelis by Chiang, Ming-Hsien, Chang, Fang-Ju, Kesavan, Dinesh Kumar, Vasudevan, Aparna, Xu, Huaxi, Lan, Kuo-Lun, Huang, Shu-Wei, Shang, Hung-Sheng, Chuang, Yi-Ping, Yang, Ya-Sung, Chen, Te-Li

“…Elizabethkingia anophelis, a nonfermenting Gram-negative bacterium, causes life-threatening health care-associated infections. …”
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High-density three-dimensional network of covalently linked nitric oxide donors to achieve antibacterial and antibiofilm surfaces by Wang, Liping, Hou, Zheng, Pranantyo, Dicky, Kang, En-Tang, Chan-Park, Mary B.

“…Our coated PU surfaces display good biocompatibility and exhibit excellent antibiofilm formation activity in vitro (up to 99.99%) against a broad spectrum of Gram-positive and Gram-negative bacteria. …”
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Use of co-cultivation method to stimulate the production of antimicrobial natural products from mangrove microorganisms by Tan, Jin Wei

“…Actinomycetes are high GC Gram-positive mycelial bacteria that are widely documented as a rich source of bioactive products, especially within the genus Streptomyces. …”
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Integrated bionic human retina process and in-sensor rc system based on 2d retinomorphic memristor array by Gong, Yue, Xing, Xuechao, Wang, Xingli, Duan, Ruihuan, Han, Su-Ting, Tay, Beng Kang

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Fabrication of bilayer nanofibrous-hydrogel scaffold from bacterial cellulose, PVA, and gelatin as advanced dressing for wound healing and soft tissue engineering by Khan, Rawaiz, Aslam Khan, Muhammad Umar, Stojanović, Goran M., Javed, Aneela, Haider, Sajjad, Abd. Razak, Saiful Izwan

“…In vitro biological studies were performed on fibroblasts (3T3) and human embryonic kidneys (HEK-293), which showed desirable cell viability, proliferation, and adhesion to the bilayer. …”
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Ocular delivery of predatory bacteria with cryomicroneedles against eye infection by Cui, Mingyue, Zheng, Mengjia, Wiraja, Christian, Chew, Sharon Wan Ting, Mishra, Arti, Mayandi, Venkatesh, Lakshminarayanan, Rajamani, Xu, Chenjie

“…The viability of B. bacteriovorus in cryoMNs remains above 80% as found in long-term storage studies, and they successfully impede the growth of gram-negative bacteria in vitro or in a rodent eye infection model. …”
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Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis by da Silva, Ronni A. G., Wong, Jun Jie, Antypas, Haris, Choo, Pei Yi, Goh, Karlyn, Jolly, Shreya, Liang, Cui, Tay, Leona Kwan Sing, Veleba, Mark, Hu, Guangan, Chen, Jianzhu, Kline, Kimberly A.

“…Here, we investigate the antibiotic and immunological activity of the anticancer agent mitoxantrone (MTX) in vitro and in vivo against vancomycin-resistant Enterococcus faecalis (VRE). …”
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New multi-target based therapeutics against an opportunistic superbug by Premkumar, Jayaraman.

“…Taken together, it is imperative to discover more potent drugs and novel therapeutic strategies to combat the infections caused by this superbug. …”
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The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection by Nielsen, Hailyn V., Guiton, Pascale S., Kline, Kimberly A., Port, Gary C., Pinkner, Jerome S., Neiers, Fabrice, Normark, Staffan, Henriques-Normark, Birgitta, Caparon, Michael G., Hultgren, Scott J.

“…We discovered that the function of Ebp pili in vivo depended on a predicted metal ion-dependent adhesion site (MIDAS) motif in EbpA’s von Willebrand factor A domain, a common protein domain among the tip subunits of sortase-assembled pili. …”
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