An enhanced deep reinforcement learning ensemble empowered by large language model by Li, Xinyi

“…At its core, LLM-DRE effectively processes and synthesizes disparate forms of market data to fine-tune trading strategies, enabling an enriched assessment of financial environments. …”
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Enhancing E. coli tolerance towards oxidative stress via engineering its global regulator cAMP Receptor Protein (CRP) by Basak, Souvik, Jiang, Rongrong

“…Classical strain engineering approaches are usually both time-consuming and labor intensive. Here, we aim to improve E. coli performance under oxidative stress via engineering its global regulator cAMP receptor protein (CRP), which can directly or indirectly regulate redox-sensing regulators SoxR and OxyR, and other ~400 genes in E. coli. …”
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Cadmium isotope fractionation during adsorption onto calcite by Peng, H, Liu, P, Zheng, H, Belshaw, NS, Hu, S, Zhu, Z

“…Notably, αsorbed-aqueous = 0.99984, a reduced but resolvably lower value fractionation, was observed in the presence of PO43− which may be an important factor to be considered when interpreting Cd isotope signatures in nature. The enrichment of lighter Cd isotopes may result from highly distorted octahedral Cdsingle bondO6 sites of inner-sphere Cd complexes on calcite, indicated by extended X-ray absorption fine structure (EXAFS). …”

Cardiac-sympathetic dysfunction in hypertension by Bardsley, E

“…Differentially expressed genes were reported and individual genes were grouped into gene families and enriched pathways to provide functional relevance. …”

Tracing RNA biography: in situ transcriptome profiling by novel spatial omics technologies by Ren, Jingyi (Rena)

“…Cell state and function are shaped by the spatiotemporal regulation of gene expression. This intricate pattern of gene expression is, in part, attained through the precise regulation of mRNA: its metabolism, transport, and translation within individual cells across spatial and temporal dimensions. …”
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Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Marques, IF, Domènech-Panicello, C, Geurtsen, ML, Hoang, TT, Richmond, R, Polinski, K, Sirignano, L, Page, CM, Binter, A, Everson, T, Burt, A, Deuschle, M, Gilles, M, Streit, F, Mumford, SL, Magnus, P, Reiss, IKM, Vermeulen, MJ, Witt, SH, Chaves, I, Yeung, E, London, SJ, Guxens, M, Felix, JF

“…In a mouse model of prenatal jet lag exposure, information on offspring DNA methylation of ten homologous genes annotated to the 16 CpGs with P < 1 × 10−5 in our analysis was available, of which eight were associated (enrichment P: 1.62 × 10−11). …”

Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve by DiGregorio, H, Mansoorshahi, S, Carlisle, SG, Tovar Pensa, C, Watts, A, McNeely, C, Sabate-Rotes, A, Yetman, A, Michelena, HI, De Backer, JFA, Mosquera, LM, Bissell, MM, Andreassi, MG, Foffa, I, Hui, DS, Caffarelli, A, Kim, YY, Citro, R, De Marco, M, Tretter, JT, McBride, KL, Body, SC, Milewicz, DM, Prakash, SK

“…These CNVs were significantly enriched compared with the general population and segregated with BAV in families. …”

Estrogenic post-menopausal anti-osteoporotic mechanism of Achyranthes aspera L.: Phytochemicals and network pharmacology approaches by Huq, AKM Moyeenul, Stanslas, Johnson, Nizhum, Nisarat, Uddin, Md. Nazim, Maulidiani, Maulidiani, Roney, Miah, Abas, Faridah, Jamal, Jamia Azdina

“…Through network pharmacology, the potential effects, and mechanisms of these compounds in osteoporosis were revealed. About 55 target genes were linked to osteoporosis. GO and KEGG enrichment suggest regulation of female reproductive hormone related signaling pathways, which are also associated with estrogen dependent osteoporosis. …”
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Investigating molecular vulnerabilities in TP53-mutant transformed myeloproliferative neoplasms by Paterson, A

“…Furthermore, all upregulated RBP were identified to be essential for cancer cell line survival via <em>in silico</em> analysis and validated by candidate RBP-targeted gene perturbation screens.…”

DNA extraction methodologies for ultra long nanopore sequencing to determine chromosome specific rodent telomere lengths by Kidd, Elliot, Mooruth, Ravi, Meimaridou, Eirini, Walley, Andrew, Fairbrother, Una

“…Telomeres are involved in gene expression through Telomere Position Effect Over Long Distance (TPE-OLD) and indirectly through telomeric repeat containing RNA (TERRA). …”
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p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice by Vernì, Fiammetta, Saggio, Isabella, Burla, Romina, La Torre, Mattia, Zanetti, Giorgia, Bastianelli, Alex, Merigliano, Chiara, Del Giudice, Simona, Vercelli, Alessandro, Di Cunto, Ferdinando, Boido, Marina

“…Mutant mice were produced by reducing the expression of the gene Ft1 (AKTIP in humans). In vitro, AKTIP/Ft1 depletion causes telomere aberrations, DNA damage, and cell senescence. …”
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A standardised fraction 1 (SF1) from clinacanthus nutans attenuates the stemness of cervical cancer stem-like cells via inhibition of notch1 signalling by Ismail, Faridah

“…Bioassay guided fractionation was employed for the isolation of SF1 from C. nutans leaf extract. The SiHa cell line was used for the enrichment of CCSCs by culturing the cells in CSC-conditioned medium (cervospheres). …”
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探 = In search of harmony by Ng, Woon Lam

“…Back in the days when I was learning the classical oil painting approach in New York Academy of Fine Art, I discovered the similarity in the painting techniques between watercolor and oil painting. …”
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Phase transitions by an abundant protein in the anammox extracellular matrix mediate cell-to-cell aggregation and biofilm formation by Seviour, Thomas, Wong, Lan Li, Lu, Yang, Mugunthan, Sudarsan, Yang, Qiaohui, Chanda Segaran, Uma Shankari, Bessarab, Irina, Liebl, David, Williams, Rohan B. H., Law, Yingyu, Kjelleberg, Staffan

“…Expression levels of Brosi_A1236, belonging to a class of proteins previously suggested to be cell surface associated, were in the top one percentile of all genes in the "Candidatus Brocadia sinica"-enriched biofilm. …”
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Dna markers and mapping of quantitative trait loci for yield and bunch quality in Deli dura X Yangambi pisifera oil palm (Elaeis guineensis) population by Seng, Tzer Ying

“…The many QTLs detected per trait suggested that the traits studied are polygenic with many genes of individual small effects on independent loci. …”
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Characterization of nickel-titanium based thin films crystallized by fast and ultra-fast annealing methods by Motemani Sharabiani, Yahya

“…The decrease in transformation temperature is caused by the fine nano-scale structure in Ti-Ni-Hf thin samples. …”
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Towards semantic, debiased and moment video retrieval by Satar, Burak

“…Our approach tackles this challenge for the first time on long, fine-grained, and untrimmed egocentric videos, while existing methodologies target short, coarse-grained, and trimmed third-person videos. …”
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