18F-labelling of new chemotypes for drug discovery by Khotavivattana, T

“…This work demonstrates that AgOTf can induce halogen exchange nucleophilic ¹⁸F-fluorination under mild reaction conditions with a wide range of substrates. …”

AI is a viable alternative to high throughput screening: a 318-target study by Wallach, Izhar, Bernard, Denzil, Nguyen, Kong, Ho, Gregory, Morrison, Adrian, Stecula, Adrian, Rosnik, Andreana, O’Sullivan, Ann Marie, Davtyan, Aram, Samudio, Ben, Thomas, Bill, Worley, Brad, Butler, Brittany, Laggner, Christian, Thayer, Desiree, Moharreri, Ehsan, Friedland, Greg, Truong, Ha, van den Bedem, Henry, Ng, Ho Leung, Stafford, Kate, Sarangapani, Krishna, Giesler, Kyle, Ngo, Lien, Mysinger, Michael, Ahmed, Mostafa, Anthis, Nicholas J., Henriksen, Niel, Gniewek, Pawel, Eckert, Sam, de Oliveira, Saulo, Suterwala, Shabbir, PrasadPrasad, Srimukh Veccham Krishna, Shek, Stefani, Contreras, Stephanie, Hare, Stephanie, Palazzo, Teresa, O’Brien, Terrence E., Van Grack, Tessa, Williams, Tiffany, Chern, Ting-Rong, Kenyon, Victor, Lee, Andreia H., Cann, Andrew B., Bergman, Bastiaan, Anderson, Brandon M., Cox, Bryan D., Warrington, Jeffrey M., Sorenson, Jon M., Goldenberg, Joshua M., Young, Matthew A., DeHaan, Nicholas, Pemberton, Ryan P., Schroedl, Stefan, Abramyan, Tigran M., Gupta, Tushita, Mysore, Venkatesh, Presser, Adam G., Ferrando, Adolfo A., Andricopulo, Adriano D., Ghosh, Agnidipta, Ayachi, Aicha Gharbi, Mushtaq, Aisha, Shaqra, Ala M., Toh, Alan Kie Leong, Smrcka, Alan V., Ciccia, Alberto, de Oliveira, Aldo Sena, Sverzhinsky, Aleksandr, de Sousa, Alessandra Mara, Agoulnik, Alexander I., Kushnir, Alexander, Freiberg, Alexander N., Statsyuk, Alexander V., Gingras, Alexandre R., Degterev, Alexei, Tomilov, Alexey, Vrielink, Alice, Garaeva, Alisa A., Bryant-Friedrich, Amanda, Caflisch, Amedeo, Patel, Amit K., Rangarajan, Amith Vikram, Matheeussen, An, Battistoni, Andrea, Caporali, Andrea, Chini, Andrea, Ilari, Andrea, Mattevi, Andrea, Foote, Andrea Talbot, Trabocchi, Andrea, Stahl, Andreas, Herr, Andrew B., Berti, Andrew, Freywald, Andrew, Reidenbach, Andrew G., Lam, Andrew, Cuddihy, Andrew R., White, Andrew, Taglialatela, Angelo

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The block by Ho, Amanda

“…This project draws its inspiration from the mild steel ventilation grilles that were commonly found on Singapore architecture in the 1900s. …”
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Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens by Karavasili, Christina, Babaee, Sahab, Kutty, Shruti, Chu, Jacqueline N., Min, Seokkee, Fitzgerald, Nina, Morimoto, Joshua, Inverardi, Nicoletta, Traverso, Giovanni

“…To fill the existing gap in drug dose personalization and simplification of complex medication regimens commonly encountered in the treatment of cardiovascular disease, tuberculosis, and tapering of corticosteroid therapy, a modular titratable polypill approach that simultaneously addresses both aspects is proposed. …”
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Gold-catalyzed cyclization of yndiamides with isoxazoles via α-imino gold Fischer carbenes by Tong, Z, Smith, PJ, Pickford, HD, Christensen, KE, Anderson, EA

“…The reaction proceeds rapidly under mild conditions, with high regioselectivity being achieved by introducing a subtle steric bias between the nitrogen substituents on the yndiamide. …”

Interfacial phenomena and biological recognition of mammalian cells on biomimetic materials by Chan, Vincent.

“…We intend to fill this gap by interrogating the biophysical events involved in membrane-polymer interaction, biological adhesion, tissue engineering and cellular fluid mechanics. …”
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Synthesis of densely functionalized pyrroles from unprotected carbohydrates by Xia, Mengxin

“…The activity of pyrrole-based drugs is tuned with the type of substituents on the pyrrole core and on the substitution pattern on the core pyrrole ring. …”
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Between City and Self: Reading Beirut in Mohamed Soueid’s Tango of Yearning by Anouti, Ghida

“…Weaving historical realism with fabulation to fill or distort representational lacuna, his film offers doubled lenses – one of his life and another of Beirut’s contemporary history. …”
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Three-component Friedel-Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(iii) electrophile by Kikuchi, Jun, Nagata, Toya, Ito, Shingo, Yoshikai, Naohiko

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Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 by Bhattacharjee, NV, Schumacher, AE, Aali, A, Almidani, O, Bandyopadhyay, S, Graham, SM, Lacey, BWH, Maude, RJ, Runghien, T, Rodriguez, JAB

“…<p><b>Funding</b></p> Bill & Melinda Gates Foundation.…”

Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Feigin, VL, Abate, MD, Abate, YH, Bandyopadhyay, S, Bennett, DA, Lacey, B, Newton, CRJ

“…<p><b>Funding</b></p> Bill & Melinda Gates Foundation.…”

Le christianisme laïc de Pierre Bayle by Hooks, JM

“…In his Pensées Diverses (1682), Bayle draws upon original sin, and in his Commentaire Philosophique (1686), Bayle uses the doctrine of the Imago Dei. …”

An experimental and simulation study of chip transportation behaviour in gundrilling by Tnay, Guan Leong

“…The experiments were conducted in vertical square tube filled with the water-glycerine solutions which have properties similar to the coolant properties with concentration of 85 % oil to 5 % oil. …”
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Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…However, it is conspicuously absent from human cells, thus establishing its biosynthetic pathways as important potential drug targets. Our knowledge about the biological roles of galactofuranose in cells is hampered by a dearth of methods by which to study it. …”
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Vypal2: a versatile peptide ligase for precision tailoring of proteins by Zhang, Dingpeng, Wang, Zhen, Hu, Side, Lescar, Julien, Tam, James P., Liu, Chuan-Fa

“…The last two decades have seen an increasing demand for new protein-modification methods from the biotech industry and biomedical research communities. Owing to their mild aqueous reaction conditions, enzymatic methods based on the use of peptide ligases are particularly desirable. …”
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Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... by Brauer, M, Roth, GA, Aravkin, AY, Bandyopadhyay, S, Bennett, DA, Browne, AJ, Graham, SM, Rodriguez, JAB, Runghien, T, Sartorius, B

“…<p><b>Funding</b></p> Bill & Melinda Gates Foundation.…”

Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study... by Dyson, ZA, Ashton, PM, Khanam, F, Chunga Chirambo, A, Shakya, M, Meiring, JE, Tonks, S, Karkey, A, Msefula, C, Clemens, JD, Dunstan, SJ, Baker, S, Dougan, G, Pitzer, VE, Basnyat, B, Qadri, F, Heyderman, RS, Gordon, MA, Holt, KE, Pollard, AJ, STRATAA Study Group

“…</p> <br> <p><strong>Funding:</strong> Wellcome Trust, Bill &amp; Melinda Gates Foundation, EU Horizon 2020, and UK National Institute for Health and Care Research.…”

Determination of operating point for a propulsive wing UAV using CFD by Chan, Chee Shuan

“…In addition, contour plots of CFD showed wake filling effect of the cross flow fan. General trends for operating points in CFD agrees with that obtained by wind tunnel testing.…”
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Reinterpreting politics in thirteenth-century south-west Wales by Brodie, HD

“…Part 3 offers new perspectives on the region’s political narrative, drawing on the preceding thematic analysis. It demonstrates that until the mid-thirteenth century there was much more political cooperation between Welsh and Marcher lords than hitherto understood and considers why the pattern of politics changed, drawing comparison with medieval Ireland.…”

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Ferrari, AJ, Santomauro, DF, Aali, A, Lacey, BWH, Rodriguez, JAB

“…<p><b>Funding</b></p> Bill & Melinda Gates Foundation.…”