Transdermal Drug Delivery by Ong, Yuhui

“…As each drugs have different molecular properties, operation parameters are varied accordingly. …”
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Genomic profiling of mycobacterium tuberculosis strains, Myanmar by Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Yeo, Tsin Wen, Hill, Philip C., Cook, Gregory M., Aung, Si Thu

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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…</p> <p>The current COVID-19 pandemic has highlighted the urgent need for vaccines and antiviral drugs. The principal topic of my DPhil centres on addressing these needs for viral infection. …”

Deep learning methods for genome-based prediction of drug resistance in Mycobacterium tuberculosis by Wang, C

“…Recent years have seen a concerning rise in drug-resistant tuberculosis cases, calling for the development of new approaches for drug susceptibility testing. …”

A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen

“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…The studies described in this thesis were undertaken to evaluate the application of paper spray mass spectrometry for direct analysis of small molecule drugs and biomarker in dried matrix spot samples. …”
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Molecular characterization of Candida auris outbreak isolates in Qatar from patients with COVID-19 reveals the emergence of isolates resistant to three classes of antifungal drugs by Abid, Fatma Ben, Salah, Husam, Sundararaju, Sathyavathi, Dalil, Lamya, Abdelwahab, Ayman H., Salameh, Sarah, Ibrahim, Emad B., Almaslmani, Muna A., Tang, Patrick, Perez-Lopez, Andres, Tsui, Clement Kin-Ming

“…Here, we investigated the molecular epidemiology of these C. auris isolates and the mechanisms associated with antifungal drug resistance.…”
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Identifying antifungal resistance mechanisms and modes of action using SAturated Transposon Analysis in Yeast (SATAY) by Karadzas, M

“…These screens reveal antifungal drug targets, transporters responsible for drug uptake or efflux, as well as metabolic, signalling and trafficking pathways affecting antifungal susceptibility. …”

Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…In part II, my first project is the development of novel drug-loaded nanogels for pH sensitive drug release, which will be described in chapter 3. …”
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RES.10-001 Making Science and Engineering Pictures, Fall 2014 by Frankel, Felice C.

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Investigation of blood pressure regulation schemes by Chai, Chang Yong

“…Hence, continuous monitoring and careful control of the infusion of drug is required. Since the middle 1970s, many researches have been conducted using various types of feedback control system to regulate blood pressure through the infusion of antihypertension drug [5]. …”
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Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens by Karavasili, Christina, Babaee, Sahab, Kutty, Shruti, Chu, Jacqueline N., Min, Seokkee, Fitzgerald, Nina, Morimoto, Joshua, Inverardi, Nicoletta, Traverso, Giovanni

“…To fill the existing gap in drug dose personalization and simplification of complex medication regimens commonly encountered in the treatment of cardiovascular disease, tuberculosis, and tapering of corticosteroid therapy, a modular titratable polypill approach that simultaneously addresses both aspects is proposed. …”
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An empirical bioethical examination of Norwegian and British doctors' views of responsibility and (de)prioritization in healthcare by Everett, JAC, Maslen, H, Nussberger, A-M, Bringedal, B, Wilkinson, D, Savulescu, J

“…Finally, some behaviours were considered more appropriate grounds for deprioritization (smoking, alcohol, drug use)—potentially because of the certainty of impact and direct link to ill health. …”

Interfacial phenomena and biological recognition of mammalian cells on biomimetic materials by Chan, Vincent.

“…We intend to fill this gap by interrogating the biophysical events involved in membrane-polymer interaction, biological adhesion, tissue engineering and cellular fluid mechanics. …”
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Antimicrobial efficacy testing of antibiotic-containing biodegradable nanopolymers against biofilm and planktonic cells. by Polimyr Caesar Dave Pelisco Dingal.

“…With efficient use of drug-encapsulated nanopolymers, bactericidal dosages are sufficiently lowered and dosing intervals can be extended due to the sustained drug release feature afforded by these efficacious nanocarriers.…”
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Undang-undang rawatan dan pemulihan dadah dari sudut pandangan global: Suatu perbandingan by Ahmad, Rusniah, Khalil, Samihah, Abdullah, Siti Alida John, A. Rahman, Aspalella, Md Isa @ Yusuff, Yusramizza, Azrae, Ahmad Nasyran, Mohd Shariff, Roos Niza

“…Viewed from the aspects of entrance into drug rehabilitation centers and arrests made on drug related offences, the problems pertaining to drug abuse and addiction has attracted the attention of authorities everywhere and many national legislative bodies have taken steps by passing legislation in the aspects of drug treatment and rehabilitation in a bid to address this social illness. …”
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Psychotropic taxonomies: constructing a therapeutic framework for psychiatry by McCutcheon, RA, Cowen, P, Nour, MM, Pillinger, T

“…Disease-based classification systems (e.g., &lsquo;antidepressant&rsquo; and &lsquo;antipsychotic&rsquo;) do not reflect the fact that psychotropic agents are used across diagnostic categories, nor account for the dimensional nature of both the psychopathology and biology of psychiatric illnesses.</p> <p>In this review we discuss the history of psychotropic drug taxonomies and their influence on both clinical practice and drug development. …”

Development and Application of a Data-Driven Signal Detection Method for Surveillance of Adverse Event Variability Across Manufacturing Lots of Biologics by Wilde, Joshua T., Springs, Stacy, Wolfrum, Jacqueline M., Levi, Retsef

“…We propose a data-driven signal detection method called HMMScan to monitor for manufacturing lot-dependent changes in adverse event (AE) rates, and herein apply it to a biologic drug. …”
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Understanding the viral protein structures of clinically relevant arboviruses and fragment-based screening for antivirals by Farhana Abu Bakar

“…In the past decade, the unprecedented emergence of arboviral diseases transmitted by Aedes mosquitoes have caused debilitating illnesses that has affected millions of people worldwide. …”
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The influence of additives on the delivery of paclitaxel from bioresorbable PLGA films by Huang, Charlotte Liwen.

“…The study of the influences of additives on the drug delivery characteristics from PLGA thin films as a coating on angioplasty balloons was reported in this thesis. …”
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