p27 is regulated independently of Skp2 in the absence of Cdk2 by Kaldis, Philipp, Kotoshiba, Shuhei, Gopinathan, Lakshmi, Pfeiffenberger, Elisabeth, Rahim, Anisa, Vardy, Leah Karen Anne, Nakayama, Keiko, Nakayama, Keiichi I.

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Host genetics maps to behaviour and brain structure in developmental mice by Asbury, S, Lai, JKY, Rilett, KC, Haqqee, Z, Darwin, BC, Ellegood, J, Lerch, JP, Foster, JA

“…To effectively assess neurodevelopment in the mouse, we developed a behavioural pipeline that incorporates several validated behavioural tests to measure translationally relevant milestones of behaviour in mice. The behavioral phenotype of 1060 wild type and genetically-modified mice was examined followed by structural brain imaging at 4 weeks of age. …”

Opto-electrical bimodal recording of neural activity in awake head-restrained mice by Cobar, Luis Fernando, Kashef, Alireza, Bose, Krishnashish, Tashiro, Ayumu

“…Electrical and optical monitoring of neural activity is major approaches for studying brain functions. Each has its own set of advantages and disadvantages, such as the ability to determine cell types and temporal resolution. …”
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Presence of IgG antibodies is not a reliable marker of Toxoplasma gondii infection in feral mice by Lignereux, Louis, Tong, Wen Han, Tan, Sijie, Vyas, Ajai, O'handley, Ryan

“…The single-celled parasite Toxoplasma gondii uses mice as a vector to reach its definitive host, the cat, where it can accomplish its sexual reproduction and produce oocysts, which will contaminate the environment. …”
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Genome-wide gene expression profiling of the Angelman syndrome mice with Ube3a mutation by Low, Daren., Chen, Ken-Shiung.

“…We observed 64 differentially expressed transcripts (7 up-regulated and 57 down-regulated) showing more than 1.5-fold differences in expression (p<0.05) when compared to wildtype mice. Pathway analysis shows that these genes are implicated in three major networks associated with signalin, nervous system development and cell death. …”
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Optogenetics-Mediated Targeted Recording from Adult-Born Granule Cells in the Dentate Gyrus of Behaving Mice by Yang, Ming

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Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice by Ivan, Fransiskus Xaverius, Kwoh, Chee Keong

“…Many individual studies have been carried out in mice to uncover the viral factors responsible for the virulence of IAV infections. …”
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Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopause-associated mood disorder in ovariectomized mice by Liang, Gengfan, Kow, Audrey Siew Foong, Lee, Yu-Zhao, Yusof, Rohana, Tham, Chau Ling, Ho, Yu-Chung, Lee, Ming Tatt

“…This work evaluated the effects of α-tocopherol and tocotrienol-rich palm oil extract on depressive and anxiety-related phenotypes induced by estrogen deficiency through ovariectomy in mice. Our study revealed that ovariectomized mice exhibited alterations in behavior indicative of depressive- and anxiety-like behaviors. …”
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Effect of Pueraria mirifica subchronic treatments on ameliorating depression by increasing tryptophan hydroxylase immunoreactive neurons via estrogen receptors in ovariectomized mi... by Nattawut Tadsaichol, Wandee Udomuksorn, Ekkasit Kumarnsit, Uraporn Vongvatcharanon, Surapong Vongvatcharanon

“…Estrogen depletion leads to menopause-associated depression. Pueraria mirifica (PM) contains phytoestrogen that has been used for rejuvenating in aged women. …”
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Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4- iodoamphetamine ((±)-DOI) on cognitive flexibility by Sabanovic, M, Lazari, A, Blanco Pozo, M, Tisca, C, Tachrount, M, Martins Bach, A, Lerch, J, Walton, M, Bannerman, D

“…Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. …”

Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections by Kam, Yiu-Wing, Lee, Cheryl Yi-Pin, Teo, Teck-Hui, Howland, Shanshan W., Siti Naqiah Amrun, Lum, Fok-Moon, See, Peter, Kng, Nicholas Qing-Rong, Huber, Roland G., Xu, Mei-Hui, Tan, Heng-Liang, Choo, Andre, Maurer-Stroh, Sebastian, Ginhoux, Florent, Fink, Katja, Wang, Cheng-I, Ng, Lisa F.P., Rénia, Laurent

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DEEP-squared: deep learning powered De-scattering with Excitation Patterning by Wijethilake, Navodini, Anandakumar, Mithunjha, Zheng, Cheng, So, Peter T. C., Yildirim, Murat, Wadduwage, Dushan N.

“…In this work, we present DEEP<jats:sup>2</jats:sup>, a deep learning-based model that can de-scatter images from just tens of patterned excitations instead of hundreds. …”
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Representation learning in the artificial and biological neural networks underlying sensorimotor integration by Suhaimi, Ahmad, Lim, Amos W. H., Chia, Xin Wei, Li, Chunyue, Makino, Hiroshi

“…Here, we trained deep RL agents and mice in the same sensorimotor task with high-dimensional state and action space and studied representation learning in their respective neural networks. …”
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Inhibition of endoplasmic reticulum stress using 4-phenyl butyrate mitigates osteoporosis in a mouse model of hindlimb suspension by Al-Daghestani, Hiba Saad Subhi

“…Osteoporosis (OP) characterized by micro-architectural deterioration of bone tissue is a common skeletal disease in the elderly and may lead to fragility fractures. It may also negatively affect implant rehabilitation and prosthesis fixation in the older people. …”
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A standardised fraction 1 (SF1) from clinacanthus nutans attenuates the stemness of cervical cancer stem-like cells via inhibition of notch1 signalling by Ismail, Faridah

“…Bioassay guided fractionation was employed for the isolation of SF1 from C. nutans leaf extract. The SiHa cell line was used for the enrichment of CCSCs by culturing the cells in CSC-conditioned medium (cervospheres). …”
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Studies on the physicochemical, biomechanical and biological properties of novel decellularized bovine scaffold for bone regeneration by Qabbani, Ali Abdul Qader Hameed Al

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Dual attention deep learning network for automatic steel surface defect segmentation by Pan, Yue, Zhang, Limao

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Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death by Martínez, Pablo, Silva, Mónica, Abarzúa, Sebastián, Tevy, María F., Jaimovich, Enrique, Constantine-Paton, Martha, Bustos, Fernando J., van Zundert, Brigitte

“…In this study, we generated primary skeletal myotubes from myoblasts derived from ALS mice expressing human mutant SOD1G93A (termed hereafter mutSOD1). …”
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Interferon-γ- and glucocorticoid-mediated pathways synergize to enhance death of CD4(+) CD8(+) thymocytes during Salmonella enterica serovar Typhimurium infection by Deobagkar-Lele, M, Chacko, SK, Victor, ES, Kadthur, JC, Nandi, D

“…The death of CD4(+) CD8(+) thymocytes is Fas-independent as shown by infection studies with lpr mice. …”

Optimization of enzymatic hydrolysis conditions for antimicrobial activity against Pantoea spp. causing rice leaf blight by Jamal, Siti Norazura, Lamasudin, Dhilia Udie, Muhialdin, Belal J., Saidi, Noor Baity, Song, Lai Kok, Yusof, Mohd Termizi

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