Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19 (COVIC-19): protocol for a randomised, open-label trial by Desmarets, M, Hoffmann, S, Vauchy, C, Rijnders, BJA, Toussirot, E, Durrbach, A, Körper, S, Schrezenmeier, E, van der Schoot, CE, Harvala, H, Brunotte, G, Appl, T, Seifried, E, Tiberghien, P, Bradshaw, D, Roberts, DJ, Estcourt, LJ, Schrezenmeier, H

Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice by Hamid, Fursham M., Makeyev, Eugene V.

“…Here we report that polypyrimidine tract-binding protein 1 (Ptbp1/PTB/hnRNP-I) controls alternate 5′ and 3′ splice site (5′ss and 3′ss) usage in a large set of mammalian transcripts. …”
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Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore by Ivan, Fransiskus Xaverius, Zhou, Xinrui, Lau, Suk Hiang, Rashid, Shamima, Teo, Jasmine S. M., Lee, Hong Kai, Koay, Evelyn S., Chan, Kwai Peng, Leo, Yee Sin, Chen, Mark I. Cheng, Kwoh, Chee Keong, Chow, Vincent T.

“…Background: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificity. …”
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Simulation on window's energy efficiency using EnergyPlus (Performing simulation on selected windows to find the most energy efficient window for residential housing) by Li, Lan.

“…Seven types of glazing system were selected to find out which type of glazing system is the most energy efficient window. …”
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Performance and validation of a digital memory test across the Alzheimer’s disease continuum by Toniolo, S, Attaallah, B, Maio, MR, Tabi, YA, Slavkova, E, Klar, VS, Saleh, Y, Idris, MI, Turner, V, Preul, C, Srowig, A, Butler, C, Thompson, S, Manohar, SG, Finke, K, Husain, M

“…Most digital metrics were able to discriminate between healthy controls and patients with mild cognitive impairment and between mild cognitive impairment and Alzheimer’s disease patients. …”

Efficacy of inactivated pasteurella multocida against the bacterial infections in broiler chickens by Koh, Sien Ling

“…Severe pneumonia and severe congestion and necrosis of lung parenchyma were also recorded. In contrast, mild hepatitis with mild necrosis and degeneration of hepatocytes and mild pneumonia with mild congestion, degeneration and necrosis at the lung parenchyma were recorded in all the scarified chickens in all group. …”
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Seroprevalence of SARS-CoV-2 in children and adolescents by Ratcliffe, H

“…It also allowed exploration of potential risk factors for COVID-19 seropositivity and the utility of symptom-based indicators of infection.</p> <br> <p>The findings of ‘STORY’ confirm that SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalisation. …”

Enzymatic preparation of diacylglycerols: lipase screening, immobilization, characterization and glycerolysis performance by Xie, Rui, Peng, Xianwu, Lee, Yee-Ying, Xie, Pengkai, Tan, Chin-Ping, Wang, Yong, Zhang, Zhen

“…Backgrounds: Glycerolysis, with its advantages of readily available raw materials, simple operation, and mild reaction conditions, is a primary method for producing diacylglycerol (DAG). …”

Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…Finally, we characterized the kinetics of a mild electrophile, the squaric ester, and assessed its utility in selectively binding and modifying a key galactofuranosyl transferase involved in mycobacterial cell wall biosynthesis. …”
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Patterns of link reciprocity in directed, signed networks by Gallo, A, Saracco, F, Lambiotte, R, Garlaschelli, D, Squartini, T

“…Although part of the ambiguities can be solved by adopting a coarser definition of balance, our results call for a different theory, accounting for the directionality of edges in a coherent manner. …”

Deep brain stimulation of the hypothalamic region: a systematic review by Mofatteh, M, Mohamed, A, Mashayekhi, MS, Skandalakis, GP, Neudorfer, C, Arfaie, S, MohanaSundaram, A, Sabahi, M, Anand, A, Aboulhosn, R, Liao, X, Horn, A, Ashkan, K

“…Future large-scale studies with long-term follow-up are required to validate the safety and efficacy data and extend these findings.…”

Anisotropic protein diffusion on nanosurface by Liu, Yang, Song, Xiaohan, Yang, Yanmei, Li, Yong-Qiang, Zhao, Mingwen, Mu, Yuguang, Li, Weifeng

“…On the MBP surface, HP35 migrates mainly along the zigzag direction but can also easily stride over the ridges and grooves along the armchair direction. Moreover, the mild binding strength between α-PC and HP35 does not cause distortion in the protein structure. …”
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Essays on blood supply management by Senga, Juan Ramon Liboro

“…The results show that more mature blood banks have more strategies available at their disposal when it comes to trying to maintain fill-rates. We also observe that the dynamic donation rate strategy results in lower fill-rates during disasters when the fill-rate is low despite being able to meet donation targets, and that multiple waves with short lead times exacerbate this effect. …”
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Role of play and playfulness in online user experience by Victoria Chattopadhyay

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The moderation effect of vendor support on cloud computing adoption and firm performance by Teh, Raymond, Subramaniam, Anusuiya

“…This study aims to fill a knowledge gap in prior technology adoption studies by determining the moderating impact of vendor support on cloud computing adoption and firm performance in Malaysian SMEs. …”
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Factors associated with body weight status and internet addiction among malaysian university students in Penang: mixed method study before and during covid-19 pandemic by Isaac, Nesamalar

“…The level of internet addiction was determined based on Young’s internet addiction self-reported scale, and students were classified as no IA users (0.3%), mild IA users (56.8%), moderate IA users (37.5%), and severe IA users (5.4%). …”
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Computer aided diagnoses for detecting the severity of Keratoconus by Abdullah, Osamah Qays, Boughariou, Aicha, Al-Azawi, Fadia W., Al-Araji, Ahmed Mohammed Khadum Abdulamer, Mehdy, Mehdy Mwaffeq

“…Disease severity was categorized into three stages, namely, mild, moderate, and severe, according to the topographic KC classification by a senior ophthalmologist. …”
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Bifunctional diazirine reagent for covalent dyeing of Kevlar and inert polymer materials by Liu, Richard Y., Luo, Shao-Xiong Lennon, Hirst, Elizabeth S., Doona, Christopher J., Swager, Timothy M.

“…The reagent's structure features a trifluoromethyl diazirine group as a precursor to a carbene that binds the textile surface. On the reagent's other terminus, a benzyl bromide group acts as a site accessible for substitution reactions. …”
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Unveiling perspectives of Islam : seeing through the eyes of Singapore's educated Chinese youths who subscribe to No religion by Nur Ameera Amirrudin

“…Finally, while the negative perceptions of respondents are rather mild, these data reveal that actions should be taken to curb this negativity.…”
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Optimising investigative pathways in military medicine: operational impact of a military cardiopulmonary exercise testing clinic by Holland, JL, Cowie, P, Gardner, L, Mulae, J, Richards, S, Holdsworth, D

“…Individuals were referred for dyspnoea (22.1%), syncope (11.4%), chest pain (8.1%) (referred to as ‘higher risk’ symptom group), and pre-syncope (8.1%), palpitations (8.1%), and fatigue and/or exercise intolerance (6.0%) (referred to as ‘lower risk’ symptom group). 34% were asymptomatic with incidental findings on cardiac screening investigations. Reduced exercise capacity was rare, affecting only 11% of individuals, which was borderline/mild at worst. …”