Loss of caveolin-1 impairs light flicker-induced neurovascular coupling at the optic nerve head by Loo, Jing Hong, Lee, Ying Shi, Woon, Chang Yi, Yong, Victor H. K., Tan, Bingyao, Schmetterer, Leopold, Chong, Rachel S.

“…However, there was no significant difference in RGC density between Cav-1 KO and wild type mice. These findings highlight the role of Cav-1 in regulating neurovascular coupling and IOP and suggest that the loss of Cav-1 may predispose to vascular dysfunction and decreased RGC signaling in the absence of structural loss. …”
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The role of PTEN in human bone marrow-derived mesenchymal stem cells mediated tumor cells suppression. by Toh, Xin Yi.

“…In parallel, isogenic glioma cell lines U251, which overexpresses wild-type PTEN upon tetracycline treatment, resulted in 1.43-fold glioma cell growth retardation when cultured in the presence of MSC. …”
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Gobo: A System for Exploring User Control of Invisible Algorithms in Social Media by Bhargava, Rahul, Chung, Anna, Gaikwad, Neil S, Hope, Alexis, Jen, Dennis, Rubinovitz, Jasmin, Saldías-Fuentes, Belén, Zuckerman, Ethan

“…Through an iterative design process, we've built and deployed Gobo in the wild and conducted a pilot study in the form of a survey to understand how the users respond to the shift of control from invisible algorithms to themselves. …”
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Wear and friction properties of pineapple leaf fibers-reinforced natural rubber composites with the influence of multi-walled carbon nanotubes by Xuan, Yeo Yi, Ridzuan, M.J.M., Abdul Majid, M.S., Syayuthi, A.R.A., Mat, Fauziah, Salit @ Sinon, Mohd Sapuan

“…The PALF content was ranged from 0, 10, 20 to 30 parts per hundred rubber (phr) while the MWCNT content was maintained at 10 phr. A two-roll mill mixing process followed by molding was employed to fabricate the NR composites. …”
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Sorptive properties of biofilm matrix for heavy metal sequestering by Elisa Tiaras

“…The characteristics and the ability to treat heavy metals in 4 strains, namely PAO1 wild-type, ΔPelA strain, ΔPslBCD strain and double mutant ΔPelA- ΔPslBCD strain, were compared in the study. 2 types of metals that are commonly found in the environment were used in the study: copper (Cu) and zinc (Zn). …”
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We’re too busy singing: acoustic analysis with apes by French, Fiona, Good, Stephen, Mokkadem, Karim, Frost, Naomi, Finch, Katherine

“…Ultimately, we are planning a deeper investigation of auditory perception, by developing interactive devices that offer agency to non-humans and enable us to find out more about the hearing capabilities of different species.…”
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Enhanced restoration of visual code after targeting ON bipolar cells compared to retinal ganglion cells with optogenetic therapy by Rogers, J, Hughes, S, Ebrahimi, A, Allen, A, Storchi, R, Lindner, M, Peirson, S, Badea, T, Hankins, M, Lucas, R

“…Our data show that, while both approaches restore visual responses with impressive fidelity, ON BC targeting produces a richer visual code closer to that of wild-type mice. …”

Urban-rural communities attitudes and perceptions toward wildlife meat consumption in Bintulu, Sarawak by Thomas, Alexander, Mariapan, Manohar, Lim, Evelyn Ai Lin, Johari, Shazali

“…Among the wildlife meat, wild boar meat is the most preferred. The findings provide guidance towards developing successful strategies and actions to influence local communities towards sustainable use of wildlife for consumption.…”

Studies on the antioxidant mechanisms of betacyanins from improved fermented red dragon fruit (Hylocereus polyrhizus) drink in HepG2 cells by Lim, Teck Wei, Lim, Renee Lay Hong, Pui, Liew Phing, Tan, Chin Ping, Ho, Chun Wai

“…The present study aimed to investigate the antioxidant mechanisms of the stabilised betacyanins in a novel RDF functional drink, Improved-FRDFD-dH2O (produced from mild, sustainable approaches) using HepG2 cell line. …”
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Assessing compounding climate-related stresses and development pathways on the power sector in the central U.S. by Gurgel, Angelo Costa, Reilly, John, Morris, Jennifer, Schlosser, C. Adam, Gao, Xiang, Yuan, Mei, Tapia-Ahumada, Karen

“…Potential supply gaps range from 5% in the North Central region under mild changes in climate to 21% in the Lakes-Mid Atlantic region under more severe climate change. …”
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Optimising investigative pathways in military medicine: operational impact of a military cardiopulmonary exercise testing clinic by Holland, JL, Cowie, P, Gardner, L, Mulae, J, Richards, S, Holdsworth, D

“…Individuals were referred for dyspnoea (22.1%), syncope (11.4%), chest pain (8.1%) (referred to as ‘higher risk’ symptom group), and pre-syncope (8.1%), palpitations (8.1%), and fatigue and/or exercise intolerance (6.0%) (referred to as ‘lower risk’ symptom group). 34% were asymptomatic with incidental findings on cardiac screening investigations. Reduced exercise capacity was rare, affecting only 11% of individuals, which was borderline/mild at worst. …”

Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study by Patone, M, Snelling, AJ, Tibble, H, Coupland, C, Sheikh, A, Hippisley-Cox, J

“…Trials have shown it to have mild to moderate side effects, however, evidence regarding its safety in real-world settings remains insufficient. …”

ECG analysis of ventricular fibrillation dynamics reflects ischaemic progression subject to variability in patient anatomy and electrode location by Martinez-Navarro, H, Bertrand, A, Doste, R, Smith, H, Tomek, J, Ristagno, G, Oliveira, RS, Weber dos Santos, R, Pandit, SV, Rodriguez, B

“…AMSA allowed the precise stratification of VF according to ischaemic severity in the remote myocardium (healthy: 23.62–24.45 mV Hz; mild ischaemia: 10.58–21.47 mV Hz; moderate ischaemia: 4.82–11.12 mV Hz). …”

Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes by Zarei, Mohammad, Barroso, Emma, Palomer, Xavier, Escolà-Gil, Joan Carles, Cedó, Lidia, Wahli, Walter, Vázquez-Carrera, Manuel

“…Finally, treatment with another PPARβ/δ agonist increased VLDLR levels in the liver of wild-type mice, but not PPARβ/δ-deficient mice, confirming the regulation of hepatic VLDLR by this nuclear receptor. …”
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Genotype-phenotype maps for gene networks: from evolution to computation by Camargo, FQ

“…For both modelling frameworks, the GRN GP maps exhibit all the structural properties found in the literature, as well as simplicity bias. We also find that the number of genotypes mapping to the wild-type phenotypes for various GRNs is unusually large, and argue that this is evidence that the structure of the GP map plays an important role in determining evolutionary outcomes.…”

Strategies to mitigate establishment under the Wolbachia incompatible insect technique by Soh, Stacy, Ho, Soon Hoe, Ong, Janet, Seah, Annabel, Dickens, Borame Sue, Tan, Ken Wei, Koo, Joel Ruihan, Cook, Alex R., Sim, Shuzhen, Tan, Cheong Huat, Ng, Lee Ching, Lim, Jue Tao

“…Our simulations indicate that these interventions do not override the intended wild type suppression of the IIT approach. These findings will inform policy makers of possible ways to mitigate the potential establishment of Wolbachia using the IIT population control strategy.…”
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Biochemical characterisation of NS2B-NS3 protease from flaviviruses by Nah, Jojo Qian Hui

“…Here, we compared the enzymatic activities of DENV NS2B47- G4SG4 NS3 Wild Type (WT) pro, DENV NS2B47- G4SG4 NS3WTSSpro with DENV NS2B47- G4SG4 NS3WTSS and Zika virus (ZIKV) NS2B-NS3 WT pro. …”
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Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…Finally, we characterized the kinetics of a mild electrophile, the squaric ester, and assessed its utility in selectively binding and modifying a key galactofuranosyl transferase involved in mycobacterial cell wall biosynthesis. …”
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新加坡当代社会同志自由的研究 = A study of homosexuals’ liberty in present day Singapore by 陈惠嫔 Tan, Mabel Hui Ping

“…Analysis of credible survey results and reports, as well as gathering personal anecdotes and surveys from respondents was done. Findings were analyzed in an attempt to understand and explain how the tension between the individuals and society at large works. …”
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Clinical and microscopic evaluation of extracapsular stabilisation technique for treatment of cranial cruciate ligament rupture in local dogs by Tahier, Abdullah

“…Mild to moderate osteoarthritis was seen, however there was no obvious different in the presence of inflammatory cells between the operated and non-operated joint fluid. …”
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