Crystallographic details of the nucleotide-binding pocket of subunit A and B of A-ATP synthases and insight into the nucleotide-binding subunit α of the Escherichia coli F-ATP synt... by Vikeramjeet Singh Tadwal

“…A region that is critical for nucleotide binding in the A- and B-subunit of A-ATP synthases is the loop called as P-loop (phosphate-binding loop). …”
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Correlative light and electron microscopy of telomeric repeat-binding factor 1 in mammalian cells by von Otter, Eric

“…Telomeric chromatin consists of ‘TTAGGG’ DNA repeats sequences, nucleosomes and specific telomere-binding proteins called “shelterin”. Shelterin is a six-protein complex that is essential for genome stability. …”
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Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice by Hamid, Fursham M., Makeyev, Eugene V.

“…Here we report that polypyrimidine tract-binding protein 1 (Ptbp1/PTB/hnRNP-I) controls alternate 5′ and 3′ splice site (5′ss and 3′ss) usage in a large set of mammalian transcripts. …”
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Mapping the structural and dynamical features of multiple p53 DNA binding domains : insights into loop 1 intrinsic dynamics by Lukman, Suryani., Lane, David P., Verma, Chandra S.

“…Loop 1 occupies two major conformational states: extended and recessed; the former but not the latter displays correlations in atomic fluctuations with those of loop 2 (~24 Å apart). Since loop 1 binds to the major groove whereas loop 2 binds to the minor groove of DNA, our results begin to provide some insight into the possible mechanism underpinning the cooperative nature of DBD binding to DNA. …”
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Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Nurkolis, Fahrul, Kurniatanty, Isma, Wiyarta, Elvan, Permatasari, Happy Kurnia, Mayulu, Nelly, Taslim, Nurpudji Astuti, Tjandrawinata, Raymond Rubianto, Hardinsyah, Hardinsyah, Tallei, Trina Ekawati, Tsopmo, Apollinaire, Radu, Son, Hadinata, Edwin, Kim, Bonglee, Ribeiro, Rosy Iara Maciel Azambuja, Syahputra, Rony Abdi

“…A natural resource with potential activity against breast cancer is forest onion, Eleutherine bulbosa (Mill.) Urb., but the identity of its active constituents and their mechanisms of action remain unexplored. …”
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Resonance modes of tall plasmonic nanostructures and their applications for biosensing by Soehartono, Alana M., Tobing, Landobasa Y. M., Mueller, Aaron D., Yong, Ken-Tye, Zhang, Dao Hua

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Structural studies of PfEMP1 bound to human cluster of differentiation 36 and of an unusual human antibody by Hsieh, F

“…<p>In <em>Plasmodium falciparum</em>-infected humans, parasites escape from splenic clearance and cause severe or chronic symptoms partly through the action of the variable surface antigens expressed on the surfaces of infected erythrocytes, called <em>P. falciparum</em> erythrocyte membrane protein 1 (<em>Pf</em>EMP1). …”

Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Valsson, Í, Warren, MT, Deane, CM, Magarkar, A, Morris, GM, Biggin, PC

“…Machine learning offers great promise for fast and accurate binding affinity predictions. However, current models lack robust evaluation and fail on tasks encountered in (hit-to-) lead optimisation, such as ranking the binding affinity of a congeneric series of ligands, thereby limiting their application in drug discovery. …”

Hodge theory and its applications to molecular data analysis by Koh, Ronald Joon Wei

“…Nevertheless, there are currently many methods to call TADs, all of which are not based on a rigorous topological mathematical model. …”
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Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket by Kannan, Srinivasaraghavan, Venkatachalam, Gireedhar, Lim, Hong Hwa, Surana, Uttam, Verma, Chandra

“…[Nature, 2016, 534, 129–132] reported a small molecule inhibitor (called EAI045) that binds at an allosteric pocket, does not compete with ATP and displays high potency and selectivity towards certain activating mutants (L858R, T790M, L858R/T790M) of EGFR, with IC50 values ranging from 3 nM to 49 nM. …”
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Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…The NMR spectroscopy titration experiments with branched chain amino acids revealed the specific binding of valine to the MtRel ACT and showed structural rearrangement upon valine binding. …”
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Targeting NAPE-PLD: assessing its potential in the fight against malaria by Goh, Xiu Ling

“…Malaria remains a major global challenge with increasing artemisinin-resistant Plasmodium falciparum. This calls for an increased need for discovering novel ring-stage drug targets. …”
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Structure and protein recognition of G-quadruplexes by Ngo, Khac Huy

“…G-rich oligonucleotides can adopt non-canonical secondary structures called G-quadruplexes (G4s) which are biologically relevant and found in applications and nanotechnology. …”
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The Mark of Cain: The crime of terrorism in times of armed conflict as interpreted by the Court of Appeal of England and Wales in R v. Mohammed Gul by Coco, A

“…On 22 February 2012, the Court of Appeal of England and Wales was called on to interpret the definition of the crime of terrorism as contained in relevant United Kingdom (UK) legislation. …”

Identification of RNA-Tis11b complexes in activated B cells. by Tang, Ngang Heok.

“…A type of RBPs, called 12-O-tetradecanoylphorbol-13-acetate (TPA) inducible sequence (TIS11) family members (Tis11, Tis11b and Tis11d), can bind to AU-rich elements (AREs) in 3’-untranslated region (3’ UTR) of mRNAs. …”
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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Compounds of a global anti-COVID-19 effort called the “Moonshot project” targeting the main protease of SARS-CoV-2 were also screened and promising compounds were progressed further to produce a specific direct-acting SARS-CoV-2 antiviral compound. …”

Surface functionalization of oil palm empty fruit bunch (OPEFB)-derived cellulose as a carboxyl platform for metal cations and dyes removal from aquatic media by Sjahro, Noerhidajat, Yunus, Robiah, Abdullah, Luqman Chuah, Abdul Rashid, Suraya, Asis, Ahmad Jaril, Kania, Dina, Karim, Alsultan

“…The abundant oil palm empty fruit bunch (OPEFB) as by-product of palm oil milling processes exhibits a potential as an alternative cellulose feedstock for bio-adsorbent. …”
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YAP-DKK1 axis restricts regeneration to the isthmus of the human gastric glands by Zagami, C

“…</p> <p>The human stomach is organised into epithelial invaginations called gastric glands. While tissue damage can trigger regeneration at the gland base, in healthy conditions, stem cell activity is restricted to an anatomical niche called the isthmus. …”

Investigating cofactor transfer for a B₁₂-dependent enzyme by Duong, Alexander T.

“…MCM relies on two other proteins, a G-protein metallochaperone called methylmalonic aciduria type A protein (MMAA) and a protein called adenosyltransferase (ATR), to load and off-load cofactor. …”
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Co-translational integration of the light harvesting complex II and its associated pigments into polymeric membranes by Zapf, Thomas

“…Fluorescence measurements of purified proteopolymersomes indicate successful binding of pigments to the proteins within this new environment. …”
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