Synergism between Curdlan and GM-CSF confers a strong inflammatory signature to Dendritic cells by Min, Lin, Siti Aminah Mohammad Isa, Fam, Wee Nih, Sze, Siu Kwan, Beretta, Ottavio, Mortellaro, Alessandra, Ruedl, Christiane

“…We further identified MAPK ERK as one possible integration site of both signals, because its phosphorylation was clearly augmented when curdlan was coapplied with GM-CSF. Our data demonstrate that the immunomodulatory activity of curdlan requires an additional signal provided by GM-CSF to successfully initiate a robust β-glucan-specific cytokine and chemokine response. …”
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Intertainer Asia (A) : programming and distributing Hollywood movies on-line in the Asia-Pacific countries by Rieck, Olaf, Tan, Shirley

“…The idea of setting up this new company was mooted in 1998 when Andrew Yap and Greg Coote discussed the business of home video distribution. …”
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Seismic performance of continuous link reinforced concrete beam-column connections subjected to earthquake loading by Mohammadamin Azimi

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Superaugmentation and stability augmentation control system for unmanned aerial vehicle by Yasser Abdullah Mahjoub Nogoud

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Investigating graph neural networks and classical feature-extraction techniques in activity-cliff and molecular property prediction by Dablander, MF

“…While such graph-based techniques hold great theoretical promise, further investigations are needed to clarify if and when they indeed manage to definitively outcompete classical molecular featurisations such as extended-connectivity fingerprints (ECFPs) and physicochemical-descriptor vectors (PDVs).…”

Automated detection of cerebral microbleeds on MR images using knowledge distillation framework by Sundaresan, V, Arthofer, C, Zamboni, G, Murchison, AG, Dineen, RA, Rothwell, PM, Auer, DP, Wang, C, Miller, KL, Tendler, BC, Alfaro-Almagro, F, Sotiropoulos, SN, Sprigg, N, Griffanti, L, Jenkinson, M

“…Our method is flexible in terms of the input modality and provides comparable cluster-wise TPR and better cluster-wise precision compared to existing state-of-the-art methods. When evaluating across different datasets, our method showed good generalizability with a cluster-wise TPR >80 % with different modalities. …”

I. Discovery and development of nickel-catalyzed 1,2-dicarbofunctionalization reactions of alkenes II. Synthesis and reactivity of nucleophilic calcium fluoride complexes with oxyg... by Apolinar, O

“…Fluoride anion delivery upon electrophiles was found to be enhanced when compared to the notorious NON ligand framework.…”

Nb and Ta intracrustal differentiation during granulite-facies metamorphism: evidence from geochemical data of natural rocks and thermodynamic modeling by Huang, G, Chen, Y, Guo, J, Palin, R, Zhao, L

“…Both continental crust and depleted mantle are characterized by subchondritic Nb/Ta, leading to a mass imbalance when compared to the bulk Earth. Even though several potential high-Nb/Ta reservoirs in Earth's core and undepleted mantle have been proposed, little attention has been given to those in the crust. …”

The role of CD1a in dengue infection by Yang, J

“…The production of IFN-γ and GM-CSF by CD1a-autoreactive T cells was reduced when co-cultured with dengue-infected presenting cells. …”

Response of invertebrate communities to intensive management of improved pasture ecosystems by Manning, P

“…While dung beetles play an important role in supporting functioning in the short term, my work also reveals that their contributions may be less evident when considered over longer periods. Chemical perturbations caused by anthelmintic residues represent a significant threat to some invertebrate groups, but my experiments show that exposure does not always translate into an immediate reduction in ecosystem functioning. …”

Obama's energy policy: the crucial role of coal in the US climate legislation by Robinson, D

“…There are many reasons, including the absence of global leadership, the difficulties of collective action in the international system, the uncertainty about when and where the bomb will explode, and the preference to let others do the heavy lifting.…”

The interrelation of EU law with inter se international agreements of the EU member states by Georgaki, K, Eleftheriadis, P

“…<p>This thesis examines how EU law interrelates with international agreements concluded between EU Member States inter se when a conflict between their norms can be identified. …”

Legal politics in the Libyan constitution-making process by van Lier, F

“…</p> <p>The Libyan example indicates that when societal conflict is high and the political landscape deeply divided, a constitution-making process is unlikely to solve conflicts through a redistribution of power or resources or the elaboration of a unitary vision for a state. …”

Behaviours and attitudes in response to the COVID-19 pandemic: insights from a cross-national Facebook survey by Perrotta, D, Grow, A, Rampazzo, F, Cimentada, J, Del Fava, E, Gil-Clavel, S, Zagheni, E

“…Respondents rapidly adopted the use of face masks when they were not yet mandatory. We observed a clear pattern in threat perceptions, sharply increasing from a personal level to national and global levels. …”

Modelling frequency-based neural responses to deep brain stimulation in Parkinson’s disease by Sermon, JJ

“…Deep Brain Stimulation (DBS) is an established therapy for Parkinson’s disease (PD) when pharmacological measures have been exhausted or following medication- associated motor control side effects. …”

Characterising the functional role of GATA1short isoform in normal and malignant haematopoiesis by Cruz Hernandez, D

“…I envision this assay can substitute for next generation sequencing of GATA1 mutational profiling when not available to help diagnose TAM and ML-DS in clinical settings.…”

Heterogeneity in definitions of surgical site infection after cranial surgery limits the validity of research findings in neurosurgery: a systematic review by Majidi, N, Sivakumar, A, Vogt, A, Ranganathan, S, Ashkan, K, Price, SJ, Lee, KS

“…It is important to be cautious when reviewing studies that report SSI-CRAN outcomes without acknowledging this heterogeneity, as the validity of their reported evidence may be limited. …”

Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets by Burchardt, JM, Mei, XW, Ranger, T, McDermott, CJ, Radunovic, A, Coupland, C, Hippisley-Cox, J

“…<p><strong>Results</strong></p> We found 6437 adults with a diagnosis of MND giving an incidence of MND of 5.69/100,000 person years (95% CI 5.51–5.88); 6.57 (6.41–6.99) in men and 4.72 (4.49–4.97) in women when age-standardized to the 2011 UK population. …”

Resistant hypertension and mortality: an observational cohort study by de la Sierra, A, Ruilope, LM, Staplin, N, Gorostidi, M, Vinyoles, E, Segura, J, Armario, P, Oliveras, A, Williams, B

“…Compared with white-coat, ABPM-confirmed resistant hypertension was associated with an increased risk of all-cause (HR, 1.45 [95% CI, 1.32-1.60]) and cardiovascular (HR, 1.68 [95% CI, 1.43-1.98]) mortalities. When ABPM-confirmed and white-coat resistant hypertension were separately compared with controlled hypertension, only the former was associated with an increased risk of death and cardiovascular death (HR, 1.36 [95% CI, 1.26-1.48] and 1.56 [95% CI, 1.36-1.79]), respectively. …”

A simple approach to improve recording of concerns about child maltreatment in primary care records: developing a quality improvement intervention by Woodman, J, Allister, J, Rafi, I, de Lusignan, S, Belsey, J, Petersen, I, Gilbert, R

“…Of 25 patients with known maltreatment, six had no maltreatment-related codes recorded, but all had relevant free text, scanned documents, or codes. When stating their reasons for undercoding maltreatment concerns, GPs cited damage to the patient relationship, uncertainty about which codes to use, and having concerns about recording information on other family members in the child’s records. …”