Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT) by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya

“…Taken together, we describe here a signalling pathway impacting ALT which can be targeted by a clinically approved drug.…”
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Trajectory of immune evasion and cancer progression in hepatocellular carcinoma by Nguyen, Phuong H. D., Wasser, Martin, Tan, Chong Teik, Lim, Chun Jye, Lai, Hannah L. H., Seow, Justine Jia Wen, DasGupta, Ramanuj, Phua, Cheryl Z. J., Ma, Siming, Yang, Jicheng, Sheena D/O Suthen, Tam, Wai Leong, Lim, Tony K. H., Yeong, Joe, Leow, Wei Qiang, Pang, Yin Huei, Soon, Gwyneth, Loh, Tracy Jiezhen, Wan, Wei Keat, Chan, Chung Yip, Cheow, Peng Chung, Toh, Han Chong, Kow, Alfred, Dan, Yock Young, Kam, Juinn Huar, Iyer, Shridhar, Madhavan, Krishnakumar, Chung, Alexander, Bonney, Glenn K., Goh, Brian K. P., Fu, Naiyang, Yu, Victor C., Zhai, Weiwei, Albani, Salvatore, Chow, Pierce K. H., Chew, Valerie

“…Immune evasion is key to cancer initiation and later at metastasis, but its dynamics at intermediate stages, where potential therapeutic interventions could be applied, is undefined. Here we show, using multi-dimensional analyses of resected tumours, their adjacent non-tumour tissues and peripheral blood, that extensive immune remodelling takes place in patients with stage I to III hepatocellular carcinoma (HCC). …”
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A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging by Kovács, Tibor, Szinyákovics, Janka, Billes, Viktor, Murányi, Gábor, Varga, Virginia B., Bjelik, Annamária, Légrádi, Ádám, Szabó, Melinda, Sándor, Sára, Kubinyi, Enikő, Szekeres-Paracky, Cecília, Szocsics, Péter, Lőke, János, Mulder, Jun, Gulyás, Balázs, Renner, Éva, Palkovits, Miklós, Gulya, Károly, Maglóczky, Zsófia, Vellai, Tibor

“…Despite its physiological and medical significance, it remains largely unknown why autophagy becomes incapable of effectively eliminating harmful cellular materials in many cells at advanced ages. Here we show that age-associated defects in autophagic degradation occur at both the early and late stages of the process. …”
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Perceived inequality in society may not motivate increased food intake in the absence of personal socioeconomic disadvantage by Cheon, Bobby K., Low, Xenia, Wijaya, Darren Jeffian, Lee, Albert

“…While these relationships could be attributed to poorer quality of health services and lower access to healthier lifestyles among disadvantaged groups in societies with greater economic inequality, this explanation does not account for those who experience relative economic security in such unequal societies (e.g., the middle and upper classes). Here, we tested whether perceptions of greater disparities between social classes in one’s society (i.e., perceived societal inequality) may promote eating behaviors that risk excess energy intake. …”
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Deep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus by Nguyen, Tram Anh, Heng, Joel Jia Wei, Ng, Yan Ting, Sun, Rui, Fisher, Shira, Oguz, Gokce, Kaewsapsak, Pornchai, Xue, Shifeng, Reversade, Bruno, Ramasamy, Adaikalavan, Eisenberg, Eli, Tan, Meng How

“…However, the scope of A-to-I RNA editing by the ADAR enzymes in Xenopus remains underexplored. Results: Here, we identify millions of editing events in Xenopus with high accuracy and systematically map the editome across developmental stages, adult organs, and species. …”
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Synergistic-potential engineering enables high-efficiency graphene photodetectors for near- to mid-infrared light by Jiang, Hao, Fu, Jintao, Wei, Jingxuan, Li, Shaojuan, Nie, Changbin, Sun, Feiying, Wu, Steve Qing Yang, Liu, Mingxiu, Dong, Zhaogang, Wei, Xingzhan, Gao, Weibo, Qiu, Cheng-Wei

“…Meanwhile, two-dimensional (2D) semimetal materials with unique zero-bandgap structures are constrained by the bottleneck of intrinsic quantum efficiency. Here, we report a near-mid infrared ultra-miniaturized graphene photodetector with configurable 2D potential well. …”
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Scalable multifunctional MOFs-textiles via diazonium chemistry by Li, Wulong, Yu, Zhen, Zhang, Yaoxin, Lv, Cun, He, Xiaoxiang, Wang, Shuai, Wang, Zhixun, He, Bing, Yuan, Shixing, Xin, Jiwu, Liu, Yanting, Zhou, Tianzhu, Li, Zhanxiong, Tan, Swee Ching, Wei, Lei

“…However, achieving scalable fabrication of MOFs-textiles with high mechanical durability remains challenging. Here, we report a facile and scalable strategy for direct MOF growth on cotton fibers grafted via the diazonium chemistry. …”
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Computational modeling of light processing in the habenula and dorsal raphe based on laser ablation of functionally-defined cells by Cheng, Ruey-Kuang, Jagannathan, N. Suhas, Kathrada, Ahmad Ismat, Jesuthasan, Suresh, Tucker-Kellogg, Lisa

“…The functional connectivity between these regions is incompletely characterized. Here, we use the ability of changes in irradiance to trigger reproducible changes in activity in the habenula and dorsal raphe of zebrafish larvae, combined with two-photon laser ablation of specific neurons, to establish causal relationships. …”
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Investigating the charge separation and transport in iron based photoanodes for solar-driven water splitting by Bassi, Prince Saurabh

“…But high temperature annealing also deforms the substrate morphology which in turn degrades the conductivity and hence trade-offs with overall performance of PEC device. Here, we have demonstrated annealing profile which proves optimal in tackling bulk recombination and simultaneously keeping intact the crystallinity of Fe2O3 nanorods and conductivity of FTO substrates. …”
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Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration by Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

“…Previous observations indicating that GADD34 is induced by arsenite, a thiol-directed oxidative stressor, in the absence of eIF2α phosphorylation suggest other roles for GADD34. Here, we report that arsenite-induced oxidative stress differs from thapsigargin- or tunicamycin-induced ER stress in promoting GADD34 transcription and the preferential translation of its mRNA in the absence of eIF2α phosphorylation. …”
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Do dual-mobility cups reduce revision risk in femoral neck fractures compared with conventional tha designs? An international meta-analysis of arthroplasty registries by Farey, JE, Masters, J, Cuthbert, AR, Iversen, P, van Steenbergen, LN, Prentice, HA, Adie, S, Sayers, A, Whitehouse, MR, Paxton, EW, Costa, ML, Overgaard, S, Rogmark, C, Rolfson, O, Harris, IA

“…</p> <p><strong>Conclusion: </strong>The proportion of dual-mobility THAs in patients with hip fractures increased over time, but there was large variation in use across countries represented here. Dual-mobility cups were not associated with a reduction in the overall risk of revision surgery in patients with hip fractures. …”

A review of homogenous ensemble methods on the classification of breast cancer data by Nur Farahaina, Idris, Mohd Arfian, Ismail

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Analysis of technological developments and potential of biomass gasification as a viable industrial process : A review by Erdiwansyah, E., Gani, Asri, Zaki, Muhammad, Rizalman, Mamat, Nizar, Muhammad, Mohd Rosdi, Salleh, Yana, Syaifuddin, Sardjono, Ratnaningsih Eko

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Graphene based-coating effective ways of preventing corrosion by Siti Maznah, Kabeb, Azman, Hassan, Zurina, Mohamad

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A review on heat transfer enhancement in a heat exchanger by Gobinathan, Sashwin Nair, Azizuddin, Abd Aziz, Oumer, Ahmed Nurye, Mohd Yusof, Taib, Ahmad Basirul Subha, Alias

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Correlated barrier hopping and ionic conduction mechanism in glycolic acid-doped alginate-PVA biopolymer electrolytes by N. M., Ghazali, Ahmad Salihin, Samsudin

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Stadium General (Scholars Talk) di Universitas Ahmad Dahlan (UAD) kupas isu ekonomi kitaran dan pengurusan sisa pintar Malaysia dan negara-negara maju by Azizul Helmi, Sofian

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Controlling interest and firm efficiency: Comparing family- and nonfamily-controlled Taiwanese cultural and creative industry firms by Kweh, Qian Long, Ting, Irene Wei Kiong, Lu, Wen-Min, Le, Hanh Thi My

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Effectiveness of influencer marketing tactics and our understanding of consumers psychology in the digital era by Muhammad Ashraf, Fauzi, Farghaly, Ahmed Taiseer, Nur Sofia Nabila, Alimin

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Artificial intelligence image generator assisted descriptive writing by Hamizah, Zahari, Siti Ainun Jariyah, Hassan, Umi Kalsom, Masrom

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