Sudden gains in internet cognitive therapy for social anxiety disorder in routine clinical practice by Yim, SH, Clark, DM, Salkovskis, PM, Thew, GR

“…<p><strong>Background:</strong>&nbsp;Sudden gains are large symptom improvements between consecutive therapy sessions. They have been shown to occur in randomised controlled trials of internet-delivered psychological interventions, but little is known about their occurrence when such treatments are delivered in routine clinical practice.…”

Pathway and network analysis of more than 2500 whole cancer genomes by Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A, Pulido-Tamayo, S, Barenboim, J, Wadi, L, Dhingra, P, Shrestha, R, Getz, G, Lawrence, MS, Pedersen, JS, Rubin, MA, Wheeler, DA, Brunak, S, Izarzugaza, JMG, Khurana, E, Marchal, K, von Mering, C, Sahinalp, SC, Valencia, A, PCAWG Drivers and Functional Interpretation Working Group, Reimand, J, Stuart, JM, Raphael, BJ, PCAWG Consortium

“…However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes from 27 tumor types compiled by the ICGC/TCGA PCAWG project that was motivated by the success of pathway and network analyses in prioritizing rare mutations in protein-coding genes. …”

Soft law, hard stakes? State commitment to non-binding international instruments and the case of the UN Declaration on the Rights of Indigenous Peoples by Villeneuve, L

“…Whilst the advantages and appeal of soft law have been widely studied, with its effects explored in both International Relations (IR) and International Law (IL) scholarship, states’ behaviour on commitment to soft law per se has remained underexplored. …”

International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak by Apea, V, Titanji, BK, Dakin, FH, Hayes, R, Smuk, M, Kawu, H, Waters, L, Levy, I, Kuritzkes, DR, Gandhi, M, Rockstroh, J, Schechter, M, Holt, M, Palich, R, Cortes, CP, Nozza, S, Mussini, C, Calmy, A, Crabtree-Ramirez, BE, Blanco, JL, Bhagani, S, Dewsnap, C, Orkin, C, On Behalf of the Mpox SHARE-NET Writing Group

“…Less than 9% of HCWs in the region of the Caribbean, Central America and South America had been offered a vaccine as compared to almost one-third in the other regions. …”

Spontaneous ventricular tachyarrhythmias in β2-adrenoceptor transgenic mice in relation to cardiac interstitial fibrosis by Nguyen, M-N, Kiriazis, H, Ruggiero, D, Gao, X-M, Su, Y, Jian, A, Han, L-P, McMullen, JR, Du, X-J

“…Myocardial fibrosis is regarded as a pivotal proarrhythmic substrate, but there have been no comprehensive studies showing a correlation between the severity of fibrosis and ventricular tachyarrhythmias (VTAs). …”

A protocol for mobilising novel finance models for collaborative health promotion and disease prevention initiatives: taking a smart capacitating investment approach in the Invest4... by Lane, J, Edwards, RT, Babarczy, B, Whiteley, H, Oruganti, V, Rutten-van Mölken, M, Costongs, C, Jani, AR, Wordsworth, S, Maassen, A, Tsiachristas, A, Davies, J, Stavenow, B, van Vliet, J, Wright, S, Papartyte, L, Camaradou, JC, Koleva-Kolarova, R

“…The term “smart capacitating investment” (SCI) has previously been used to understand how to best boost social infrastructure investment in education, health, transport and housing across the EU. …”

Due regard obligations in the law of the sea convention by Fasia, EE

“…The content and function of these obligations have not been thoroughly and systematically studied and their application in practice can be problematic due to their indeterminate stipulation. …”

BRCA1 regulation of breast cancer cell motility by Hernandez Nuñez, ZE

“…Mutations in BRCA1 have been implicated in the increased risk of developing several cancers. …”

Evolution of an extracellular pathogen recognition mechanism in Solanaceae by Kourelis, J

“…Although many <em>R</em> genes have been identified, the molecular mechanism by which they function is only understood for a few.…”

Unfinished business: legalisation and implementation in business and human rights by Palmer, C

“…At the transnational level, the thesis discusses the Kimberley Process Certification Scheme (KPCS), the Extractive Industries Transparency Initiative (EITI), and the Voluntary Principles on Security and Human Rights (VPs), which have been selected as representative of the range of hybrid schemes increasingly developed by government and industry representatives to ameliorate the impact of TNCs on human rights.…”

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase by Rydzik, AM

“…</p> <p>In addition to the mechanistic and functional studies, the potential of BBOX as a biocatalytic tool was examined. BBOX has been shown to catalyse a hydroxylation of the symmetrical dialkyl piperidine carboxylic acids, leading to formation of up to three stereocentres in one reaction.…”

A Dirichlet-multinomial mixed model for determining differential abundance of mutational signatures by Morrill Gavarró, L, Couturier, D, Markowetz, F

“…These imprints are called mutational signatures and they have been characterised for point mutations, structural variants and copy number changes. …”

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…This is partly due to the technically challenging aspect of capturing live mRNA dynamics and partly because only a few examples have been studied in detail. I begin to fill this technological gap by assessing and applying state-of-the-art methods from the fields of microscopy and image processing. …”

Characterization of ubiquitin-activated DNA-protein crosslink repair in vitro by Zhu, X

“…SPRTN, a DNA-dependent metalloprotease, has been identified as the major protease in repairing DPCs. …”

Building fabric improvement and heat pump deployment: a set of policy conundrums by Killip, G, Topouzi, M, Fawcett, T

“…<p>Minimum building energy efficiency standards and retrofit targets for fabric improvement have long been a cornerstone of effective policy for energy demand. …”

Immunological screening of Lassa virus among health workers and contacts of patients of Lassa fever in Ondo State by Shaibu, JO, Salu, OB, Amoo, OS, Idigbe, I, Musa, AZ, Ezechi, OC, Abejegah, C, Ayodeji, O, Salako, BL, Omilabu, SA, Audu, RA

“…It could also be suggestive that a good personal protective procedure is been practiced by the health workers, hence the low exposure. …”

Practitioner, patient and public views on the acceptability of mobile stroke units in England and Wales: A mixed methods study by Moseley, L, McMeekin, P, Price, C, Shaw, L, Laws, A, Allen, M, Ford, GA, James, M, McCarthy, S, McClelland, G, Park, LJ, Pearn, K, Phillips, D, White, P, Wilson, D, Scott, J

“…Despite growing use of MSUs internationally, to date there have been no studies in NHS England and NHS Wales exploring the acceptability of MSUs to clinicians, patient and public representatives and other key stakeholders, which are important when considering potential feasibility and implementation. …”

Curing through questioning? A cross-cultural analysis of Pyrrhonism, Madhyamaka, and their potential as philosophical therapy by Brons, R

“…</p> <p>Despite their striking similarities, very few attempts have been made to learn about Pyrrhonism and Madhyamaka by studying them in conjunction. …”

Zinc absorption from maize-based meals enriched with edible house crickets: a randomized crossover stable-isotope study in Kenyan pre-school children by Hilaj, N, Boit, T, Andang’o, P, Zeder, C, Mwangi, MN, Hummel, M, Velazco, ON, van Loon, JJA, Dicke, M, Zimmermann, MB, Melse-Boonstra, A

“…Edible insects have been proposed as a novel and sustainable source of protein and other essential nutrients for human consumption but nutrient absorption efficiency is still uncertain. …”

Three essays on frictions of trade by Li, W

“…Neighbours of both countries would have been impacted due to the spillover effects.</p>…”