Dengue Virus Non-Structural Protein 5 by El Sahili, Abbas, Lescar, Julien

“…In addition to their roles in RNA replication within the infected cell, NS proteins help the virus escape the host innate immunity and reshape the host-cell inner structure. …”
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Iranian and Saudi mutual (mis)representations: a study of the relationship between discourses of othering, political confrontation and sectarian strife by Mohammad, T

“…The Othering framework employed marks a shift in the longstanding understanding of ‘rivalry’ in the SaudiIranian setting, where the relations between these two sides were dependent on the perceptions of each other, rather than embodying any innate or deeply grounded ideological fervour</p>…”

Germinal centre B cell and T follicular helper cell responses to viral vector and protein-in-adjuvant vaccines by Wang, C, Hart, M, Chui, C, Ajuogu, A, Brian, IJ, de Cassan, SC, Borrow, P, Draper, SJ, Douglas, AD

“…We found little evidence that innate immune activation by adenovirus may act as an adjuvant in such a manner that the humoral response to a recombinant protein may be enhanced by co-administering with an adenovirus lacking a transgene of interest.…”

Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6 by Zhang, Xiulin, He, Yang, Zhang, Xiaolu, Fu, Bo, Song, Zidai, Wang, Liang, Fu, Rui, Lu, Xuancheng, Xing, Jin, Lv, Jianyi, Guo, Meng, Huo, Xueyun, Liu, Xin, Lu, Jing, Du, Xiaoyan

“…The gastric epithelium acts as the first line of defense against H. pylori, with Toll-like receptors (TLRs) in gastric epithelial cells being sensitive to H. pylori components and subsequently activating the innate immune system. However, the mechanism of immune tolerance induced by H. pylori through the TLR signalling pathway has not been fully elucidated. …”
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Simulation Tools for Inclusive Design Solutions by Raviselvam, Sujithra, Al-Megren, Shiroq, Keane, Kyle, Hölttä-Otto, Katja, Wood, Kristin L, Yang, Maria C

“…<jats:p>Disability has been redefined by the World Health Organization as a function of a person’s interaction with the environment and not merely an innate part of a person. This redefinition highlights the need for inclusiveness in design solutions. …”
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Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish by Goh, Boon Chong, Larsson, Simon, Dam, Linh Chi, Ling, Sharon Yan Han, Chua, Patrina Wei Lin, Abirami, R., Singh, Samsher, Ong, Ernest Jun Long, Teo, Jeanette W. P., Ho, Peiying, Ingham, Philip William, Pethe, Kevin, Dedon, Peter C.

“…Because of its extensive innate resistance to numerous antibiotics, treatment options are limited, often resulting in poor clinical outcomes. …”
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Oligopeptide self-assembly: mechanisms, stimuli-responsiveness, and biomedical applications by Ge, Lei, Xu, Hanyan, Jiang, Xin, Yu, Jing

“…This approach paves the way for more precise tumor targeting, personalized medicinal treatments, and well-regulated drug dispensation. Their innate biocompatibility and proficiency in replicating the extracellular matrix render them ideally suited for applications such as tissue engineering, wound remediation, and regenerative medicine. …”
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Supported Lipid Bilayer Platform To Test Inhibitors of the Membrane Attack Complex: Insights into Biomacromolecular Assembly and Regulation by Yorulmaz, Saziye, Jackman, Joshua Alexander, Hunziker, Walter, Cho, Nam-Joon

“…Complement activation plays an important role in innate immune defense by triggering formation of the membrane attack complex (MAC), which is a biomacromolecular assembly that exhibits membrane-lytic activity against foreign invaders including various pathogens and biomaterials. …”
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Synergism between Curdlan and GM-CSF confers a strong inflammatory signature to Dendritic cells by Min, Lin, Siti Aminah Mohammad Isa, Fam, Wee Nih, Sze, Siu Kwan, Beretta, Ottavio, Mortellaro, Alessandra, Ruedl, Christiane

“…The integration of both signals clearly prime and tailor a more effective innate and adaptive response against invading microbes and fungi.…”
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Functional characterisation of multiple sclerosis-­associated single nucleotide polymorphisms in the Eomesodermin region by Leach, O

“…</p> <p>Subsequently, Eomes expression was characterised in peripheral blood cell populations, with the highest expression detected in natural killer cells and effector/memory T cell subsets, including MAIT cells, an innate-like lymphocyte population. To investigate potential genotype dependent changes in Eomes expression and the effect on downstream pathways, studies were performed using samples from healthy donors prospectively genotyped for the two MS associated loci. …”

Key transcriptional regulators of neutrophil function in inflammation by Ai, Z

“…<p>Neutrophils are important effector cells in innate immunity, possessing a wide range of effector functions, including reactive oxygen species (ROS) production, phagocytosis and chemotaxis. …”

Evolution of an extracellular pathogen recognition mechanism in Solanaceae by Kourelis, J

“…<p>The innate immune system of plants depends on resistance (<em>R</em>) genes which provide durable resistance to pathogens in nature. …”

Wolbachia-mosquito interactions and engineered female-specific lethality for Aedes-arbovirus control by Molloy, JC

“…In Chapter 2, I examine in <em>Ae. albopictus</em> the hypothesis that reactive oxygen species (ROS) induced immune activation plays a role, but neither ROS nor innate immune pathways were upregulated. In Chapter 3, an untargeted analysis of the <em>Ae. albopictus</em> lipidome showed it is significantly altered by <em>Wolbachia</em> infection, highlighting sphingolipids as candidates for future investigations into DENV-refractoriness.…”

Assessment of phagocytosis and cytokine secretions by monocytes in the presence of plasmodium falciparum by Xuan, Keh Min

“…Following phagocytosis, the monocytes produced TNF-α, initiating innate immune response to help in the clearance of parasite. …”
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Effects of transport inhibitors on the cellular uptake of liposomes from mycobacterium smegmatis by human monocytes dendritic cells by Nordin, Nor Asyikin

“…It provides an essential link between innate and adaptive immunity. Due to strong immune activation function and natural adjuvant properties, it makes them a valuable target for antigen delivery. …”
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The impact of protozoan predation on the pathogenicity of Vibrio cholerae by Espinoza-Vergara, Gustavo, Hoque, M. Mozammel, McDougald, Diane, Noorian, Parisa

“…Many of these intra-phagosomal factors used to kill and digest bacteria are highly conserved between eukaryotic cells and thus are also expressed by the innate immune system in the gastrointestinal tract as the first line of defense against bacterial pathogens. …”
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Emerging roles of downstream of kinase 3 in cell signaling by Loh, Jia Tong, Teo, Joey Kay Hui, Lim, Hong-Hwa, Lam, Kong-Peng

“…In this review, we will focus on the structure and expression profile of Dok-3 and highlight its role during signal transduction in B cells, innate cells as well as in bone and lung tissues.…”
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Transcriptional regulation of type I interferon responses of myeloid antigen presenting cells by Sin, Wei Xiang

“…Macrophages, as crucial mediators of an innate immune response, exhibit functional plasticity by playing an essential role in both the initiation and resolution of inflammation. …”
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Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis by Sonesson, Andreas, Przybyszewska, Kornelia, Eriksson, Sigrid, Mörgelin, Matthias, Kjellström, Sven, Davies, Julia, Potempa, Jan, Schmidtchen, Artur

“…Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to bacterial colonization and infection. …”
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Mendelian randomization identifies proteins involved in neurodegenerative diseases by Belbasis, L, Morris, S, Van Duijn, C, Bennett, D, Walters, R

“…The newly-associated proteins indicated the involvement of complement (C1S, C1R), microglia (SIRPA, SIGLEC9, PRSS8) and lysosomes (CLN5) in AD, interleukin-6 pathway (CTF1) in PD, lysosomes (TPP1), blood–brain barrier integrity (MFAP2) and astrocytes (TNFSF13) in ALS, and blood–brain barrier integrity (VEGFB), oligodendrocytes (PARP1), node of Ranvier and dorsal root ganglion (NCS1, FLRT3, CDH15), and innate immune system (CR1, AHSG, WARS) in MS. Our study demonstrates how harnessing large-scale genomic and proteomic data can yield novel insights into the role of plasma proteome in the pathogenesis of neurodegenerative diseases.…”